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Molecular cloning and functional characterizationof orphan receptorthat regulate onset of type1 diabetes

Research Project

Project/Area Number 21790479
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeSingle-year Grants
Research Field Immunology
Research InstitutionTokyo University of Science

Principal Investigator

SHIRATORI Ikuo  Tokyo University of Science, 生命科学研究所, 助教 (90379090)

Project Period (FY) 2009 – 2010
Project Status Completed (Fiscal Year 2010)
Budget Amount *help
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2010: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Fiscal Year 2009: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
Keywords免疫学 / I型糖尿病 / KIAA0350 (Clec16a) / KIAAO350 / KIAA0350
Research Abstract

Clec16a (KIAA0350) is a novel type1 diabetes gene that was identified by genome-wide association study. In this study, we report that Clec16a transcripts were critically induced in pancreas of diabetic, but not prediabetic, NOD mice. Furthermore, we have identified that MIN6 insulinoma expressed ligands for Clec16a, and ectopic expression of Clec16a in MIN6 cells induced NKG2D-ligands expression. Our findings reveal a new regulatory mechanism of onset of type1 diabetes by Clec16a and its ligand.

Report

(3 results)
  • 2010 Annual Research Report   Final Research Report ( PDF )
  • 2009 Annual Research Report
  • Research Products

    (6 results)

All 2009 Other

All Journal Article (2 results) (of which Peer Reviewed: 1 results) Remarks (4 results)

  • [Journal Article] Herpes simplex virus 1 protein kinase Us3 phosphorylates viral envelope glycoprotein B and regulates its expression on the cell surface.2009

    • Author(s)
      Kato, A., Arii, J., Shiratori, I., Akashi, H., Arase, H, Kawaguchi, Y.
    • Journal Title

      J.Viol. 83(1)

      Pages: 250-261

    • Related Report
      2010 Final Research Report
  • [Journal Article] Herpes simplex virus 1 protein kinase Us3 phosphorylates viral envelope glycoprotein B and regulates its expression on the cell surface.2009

    • Author(s)
      Kato A
    • Journal Title

      Journal of Virology 83

      Pages: 250-261

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Remarks] ホームページ等

    • Related Report
      2010 Final Research Report
  • [Remarks] 研究室のホームページ

    • URL

      http://www.rs.noda.sut.ac.jp/~ribsjm/indexj.html

    • Related Report
      2010 Final Research Report
  • [Remarks] 研究室ホームページ

    • URL

      http://www.rs.noda.sut.ac.jp/~risbjm/indexj.html

    • Related Report
      2010 Annual Research Report
  • [Remarks] 研究室ホームページ

    • URL

      http://www.rs.noda.sut.ac.jp/~ribsjm/indexj.html

    • Related Report
      2009 Annual Research Report

URL: 

Published: 2009-04-01   Modified: 2016-04-21  

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