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Analysis of immunological synapse in physiological condition

Research Project

Project/Area Number 21790486
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeSingle-year Grants
Research Field Immunology
Research InstitutionThe Institute of Physical and Chemical Research

Principal Investigator

TANE Akiko  独立行政法人理化学研究所, 免疫シグナル研究グループ, 研究員 (10415226)

Project Period (FY) 2009 – 2011
Project Status Completed (Fiscal Year 2011)
Budget Amount *help
¥3,380,000 (Direct Cost: ¥2,600,000、Indirect Cost: ¥780,000)
Fiscal Year 2011: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2010: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2009: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Keywords免疫シナプス / T 細胞抗原受容体 / 蛍光イメージング / 細胞骨格 / T細胞抗原受容体
Research Abstract

When T cells recognize antigen on antigen.presenting cells, they start adhere and generate T cell antigen receptors (TCR) microclusters (TCR-MCs) which is a unit for starting T cell activation. The TCR-MCs move toward the center of the interface and form immunological synapse. We revealed and published that the transportation of TCR-MCs depends on microtubule motor, dynein and negatively regulate T cell activation. These observation were based on the quantitative analysis of TCR-MCs generated under physiological stimulus conditions.

Report

(4 results)
  • 2011 Annual Research Report   Final Research Report ( PDF )
  • 2010 Annual Research Report
  • 2009 Annual Research Report
  • Research Products

    (28 results)

All 2012 2011 2010 2009 Other

All Journal Article (7 results) (of which Peer Reviewed: 7 results) Presentation (17 results) Remarks (4 results)

  • [Journal Article] Dynein-Driven Transport of T Cell Receptor Microclusters Regulates Immune Synapse Formation and T Cell Activation2011

    • Author(s)
      Akiko Hashimoto-Tane, Tadashi Yokosuka, Kumiko Sakata-Sogawa, Machie Sakuma, Chitose Ishihara, Makio Tokunaga, Takashi Saito
    • Journal Title

      Immunity

      Volume: 34 Pages: 919-931

    • Related Report
      2011 Annual Research Report 2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] T cell receptor-microclusters critical for T-cell activation are formed independently of lipid raft clustering2010

    • Author(s)
      Hashimoto-Tane A, Yokosuka T, Ishihara C, Sakuma M, Kobayashi W and Saito, T
    • Journal Title

      Molecular and Cellular Biology

      Volume: 30 (14) Pages: 3421-3429

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Spatiotemporal basis of CTLA-4 costimulatory molecule-mediated negative regulation of T cell activation2010

    • Author(s)
      Yokosuka, T, Kobayashi, W, Takamatsu, M, Sakata-Sogawa, K, Zeng, H, Hashimoto-Tane, A, Yagita, H, Tokunaga, M, Saito, T
    • Journal Title

      Immunity

      Volume: 33(3) Pages: 326-339

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Dynamic regulation of T cell activation and co-stimulation through TCR-microclusters2010

    • Author(s)
      Saito, T, Yokosuka, T. and Hashimoto-Tane, A
    • Journal Title

      FEBS Letters

      Volume: 584 Pages: 4865-4871

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] T cell receptor-microclusters critical for T-cell activation are formed independently of lipid raft clustering.2010

    • Author(s)
      Hashimoto-Tane A, Yokosuka T, Ishihara C, Sakuma M, Kobayashi W, Saito, T
    • Journal Title

      Molecular and Cellular Biology

      Volume: 30(14) Pages: 3421-3429

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Spatiotemporal basis of CTLA-4 costimulatory molecule-mediated negative regulation of T cell activation.2010

    • Author(s)
      Yokosuka, T, Kobayashi, W, Takamatsu, M, Sakata-Sogawa, K, Zeng, H, Hashimoto-Tane, A, Yagita, H, Tokunaga, M, Saito, T
    • Journal Title

      Immunity

      Volume: 33(3) Pages: 326-339

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Dynamic regulation of T cell activation and co-stimulation through TCR-microclusters.2010

    • Author(s)
      Saito, T, Yokosuka, T., Hashimoto-Tane, A
    • Journal Title

      FEBS Letters

      Volume: 584 Pages: 4865-4871

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Presentation] 免疫シナプス形成を担うダイニンによるT 細胞抗原受容体運搬の分子機構2012

    • Author(s)
      多根(橋本)彰子、横須賀忠、斉藤隆
    • Organizer
      第85回日本薬理学会年会
    • Place of Presentation
      京都
    • Year and Date
      2012-03-16
    • Related Report
      2011 Final Research Report
  • [Presentation] 免疫シナプス形成を担うダイニンによるT細胞抗原受容体運搬の分子機構2012

    • Author(s)
      多根(橋本)彰子
    • Organizer
      第85回日本薬理学会年会
    • Place of Presentation
      京都
    • Year and Date
      2012-03-16
    • Related Report
      2011 Annual Research Report
  • [Presentation] モーター分子ダイニンによるT 細胞受容体ミクロクラスター輸送を介した活性化制御2012

    • Author(s)
      多根(橋本)彰子
    • Organizer
      第21回東京免疫フォーラム
    • Place of Presentation
      東京
    • Year and Date
      2012-03-08
    • Related Report
      2011 Final Research Report
  • [Presentation] モーター分子ダイニンによるT細胞受容体ミクロクラスター輸送を介した活性化制御2012

    • Author(s)
      多根(橋本)彰子
    • Organizer
      第21回東京免疫フォーラム
    • Place of Presentation
      東京(招待講演)
    • Year and Date
      2012-03-08
    • Related Report
      2011 Annual Research Report
  • [Presentation] 免疫シナプスにおけるダイニンによるT 細胞ミクロクラスター運搬の分子機構2011

    • Author(s)
      多根(橋本)彰子、横須賀忠、斉藤隆
    • Organizer
      第40回日本免疫学会学術集会
    • Place of Presentation
      千葉
    • Year and Date
      2011-11-29
    • Related Report
      2011 Final Research Report
  • [Presentation] 免疫シナプスにおけるダイニンによるT細胞ミクロクラスター運搬の分子機構2011

    • Author(s)
      多根(橋本)彰子
    • Organizer
      第40回日本免疫学会学術集会
    • Place of Presentation
      千葉
    • Year and Date
      2011-11-29
    • Related Report
      2011 Annual Research Report
  • [Presentation] Dynein-driven transport of TCR microclusters forms Immune synapse and regulates T cell activation2011

    • Author(s)
      Hashimoto-Tane,A., Yokosuka, T., Sakuma, M. and Saito, T
    • Organizer
      The 84th Annual Meeting of The Japanese Pharmacology Society
    • Place of Presentation
      on line
    • Related Report
      2011 Final Research Report
  • [Presentation] Dynein-driven transport of TCR microclusters forms Immune synapse and regulates T cell activation.2011

    • Author(s)
      Hashimoto-Tane, A., Yokosuka, T., Sakuma, M., Saito, T.
    • Organizer
      The 84^<th> Annual Meeting of The Japanese Pharmacology Society
    • Place of Presentation
      横浜
    • Related Report
      2010 Annual Research Report
  • [Presentation] Dynein-driven transport of TCR microclusters forms Immune synapse and regulates T cell activation2010

    • Author(s)
      Hashimoto-Tane,A., Saito, T
    • Organizer
      The 16th Takeda Science Foundation Symposium on Bioscience
    • Place of Presentation
      東京
    • Year and Date
      2010-12-01
    • Related Report
      2011 Final Research Report
  • [Presentation] Dynein-mediated translocation of TCR microclusters along microtubules to form csmac during T cell activation2010

    • Author(s)
      Hashimoto-Tane, Yokosuka,T., Machie Sakuma, Takashi Saito
    • Organizer
      14th International Congress of Immunology
    • Place of Presentation
      神戸
    • Year and Date
      2010-08-24
    • Related Report
      2011 Final Research Report
  • [Presentation] Dynein-mediated translocation of TCR microclusters along microtubules to form cSMAC Keystone Symposia2010

    • Author(s)
      Hashimoto-Tane,A., Yokosuka, T., Saito, T
    • Organizer
      Lymphocyte Activation and Gene Expression
    • Place of Presentation
      Breckenridge (USA)
    • Year and Date
      2010-03-01
    • Related Report
      2011 Final Research Report
  • [Presentation] Dynein-mediated translocation of TCR microclusters along microtubules to form cSMAC2010

    • Author(s)
      橋本彰子(多根), 横須賀忠, 斉藤隆
    • Organizer
      Keystone Symposia Lymphocyte Activation and Gene Expression
    • Place of Presentation
      Breckenridge(USA)
    • Year and Date
      2010-03-01
    • Related Report
      2009 Annual Research Report
  • [Presentation] Dynein-mediated translocation of TCR microclusters along microtubules to form csmac during T cell activation2010

    • Author(s)
      Hashimoto-Tane, Yokosuka, T., Machie Sakuma, Takashi Saito
    • Organizer
      14^<th> International Congress of Immunology
    • Place of Presentation
      神戸
    • Related Report
      2010 Annual Research Report
  • [Presentation] Dynein-driven transport of TCR microclusters forms Immune synapse and regulates T cell activation2010

    • Author(s)
      Hashimoto-Tane, A., Saito, T.
    • Organizer
      The 16^<th> Takeda Science Foundation Symposium on Bioscience
    • Place of Presentation
      東京
    • Related Report
      2010 Annual Research Report
  • [Presentation] T細胞活性化及びcSMAC形成につながる微小管モーター・ダイニンによるTCRミクロクラスターの移動2009

    • Author(s)
      橋本彰子(多根)、横須賀忠、斉藤隆
    • Organizer
      第39回日本免疫学会総会・学術集会
    • Place of Presentation
      大阪
    • Year and Date
      2009-12-03
    • Related Report
      2011 Final Research Report 2009 Annual Research Report
  • [Presentation] TCR microclusters move along microtubules in early T cell activation2009

    • Author(s)
      Hashimoto-Tane, A., Yokosuka, T.,Ishihara, C. and Saito, T
    • Organizer
      The 5th International Workshop of Kyoto T Cell Conference
    • Place of Presentation
      Kyoto
    • Year and Date
      2009-06-01
    • Related Report
      2011 Final Research Report
  • [Presentation] TCR microclusters move along microtubules in early T cell activation2009

    • Author(s)
      Hashimoto-Tane, A., Yokosuka, T, Ishihara, C., Saito, T.
    • Organizer
      The 5^<th> International Workshop of Kyoto T Cell Conference
    • Place of Presentation
      Kyoto
    • Year and Date
      2009-06-01
    • Related Report
      2009 Annual Research Report
  • [Remarks] Immunity preview

    • URL

      http://www.sciencedirect.com/science/article/pii/S1074761311002354

    • Related Report
      2011 Final Research Report
  • [Remarks] 理化学研究所プレスリリース

    • URL

      http://www.riken.jp/r-world/info/release/press/2011/110624_2/detail.html

    • Related Report
      2011 Final Research Report
  • [Remarks] ライフサイエンス 新着論文レビュー

    • URL

      http://first.lifesciencedb.jp/archives/3201

    • Related Report
      2011 Final Research Report
  • [Remarks]

    • URL

      http://first.lifesciencedb.jp/archives/3201

    • Related Report
      2011 Annual Research Report

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Published: 2009-04-01   Modified: 2016-04-21  

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