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Protection afforded by a selective thromboxane A2 (TXA2) synthase inhibitor, ozagrel, against drug-induced liver injury.

Research Project

Project/Area Number 21790524
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeSingle-year Grants
Research Field Applied pharmacology
Research InstitutionKumamoto University

Principal Investigator

ISHITSUKA Yoichi  Kumamoto University, 大学院・生命科学研究部, 助教 (70423655)

Research Collaborator TOMISHIMA Yoshiro  熊本大学, 薬学教育部, 大学院生
MATSUNAGA Naoya  九州大学, 薬学研究科(研究院), 助教
TAKEURA Hiroyuki  熊本赤十字病院, 薬剤部, 薬剤師
OHDO Shigehiro  九州大学, 薬学研究科(研究院), 教授
IRIE Tetsumi  熊本大学, 大学院・+J47生命科学研究部, 教授
Project Period (FY) 2009 – 2010
Project Status Completed (Fiscal Year 2010)
Budget Amount *help
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2010: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2009: ¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000)
Keywordsオザグレル / トロンボキサンA2 / アセトアミノフェン / 肝傷害 / 有害事象
Research Abstract

This study was conducted to evaluate the effects of ozagrel, a selective thromboxane A2 synthase inhibitor, against acetaminophen-induced hepatic injury in mouse. Ozagrel effectively attenuated the acetaminophen-induced hepatic damage as indicated by the serum ALT, and oncotic necrosis and nuclear DNA fragmentation in liver in dose- and time-dependent manner. In addition, delayed administration of the ozagrel was more effective than N-acetylcysteine after the acetaminophen liver injury. The results suggest that ozagrel is a promising drug candidate for preventing acetaminophen-induced hepatic injury.

Report

(3 results)
  • 2010 Annual Research Report   Final Research Report ( PDF )
  • 2009 Annual Research Report
  • Research Products

    (8 results)

All 2010 Other

All Presentation (5 results) Remarks (1 results) Patent(Industrial Property Rights) (2 results)

  • [Presentation] 薬剤性肝傷害に著効を示すオザグレル塩酸塩の有用性評価2010

    • Author(s)
      富島喜朗、石塚洋一, ほか
    • Organizer
      第27回日本薬学会九州支部大会
    • Place of Presentation
      長崎大学(長崎市)
    • Year and Date
      2010-12-11
    • Related Report
      2010 Annual Research Report
  • [Presentation] 薬剤性肝傷害に著効を示すオザグレル塩酸塩の有用性評価2010

    • Author(s)
      富島喜朗, 石塚洋一, 松永直哉, 永留美菜子, 入倉充, 大戸茂弘, 入江徹美
    • Organizer
      第27回日本薬学会九州支部大会
    • Place of Presentation
      長崎市,長崎大学
    • Related Report
      2010 Final Research Report
  • [Presentation] 非ステロイド性消炎鎮痛薬の使用が困難な成人患者への小児用アセトアミノフェン坐剤の使用およびその有効性と安全性に関する検討2010

    • Author(s)
      竹浦宏幸, 田添光二, 石塚洋一, 入倉充, 上田賢太郎, 岩田一史, 下石和樹, 陣上祥子, 吉田稔, 入江徹美, 福永栄子
    • Organizer
      第20回日本医療薬学会年会
    • Place of Presentation
      千葉市,幕張メッセ
    • Related Report
      2010 Final Research Report
  • [Presentation] 高用量アセトアミノフェン坐剤の製剤特性及び有効性に関する検討2010

    • Author(s)
      田添光二, 竹浦宏幸, 野田寛子, 石塚洋一, 入倉充, 入江徹美, 吉田稔, 定永明子, 永田浩泰, 陣上祥子, 福永栄子
    • Organizer
      第20回日本医療薬学会年会
    • Place of Presentation
      千葉市,幕張メッセ
    • Related Report
      2010 Final Research Report
  • [Presentation] アセトアミノフェン誘発肝障害に対する抗酸化薬の効果2010

    • Author(s)
      石塚洋一, 富島喜朗, 永留美菜子, 近藤悠希, 入倉充, 入江徹美
    • Organizer
      日本薬学会第130年会
    • Place of Presentation
      岡山市,岡山コンベンションセンター,岡山県桃太郎アリーナ
    • Related Report
      2010 Final Research Report
  • [Remarks] ホームページ等

    • URL

      http://www.pharm.kumamoto-u.ac.jp/Labs/dcci/

    • Related Report
      2010 Final Research Report
  • [Patent(Industrial Property Rights)] アセトアミノフェン肝傷害治療剤2010

    • Inventor(s)
      石塚洋一、富島 喜朗、入倉充、入江徹美
    • Industrial Property Rights Holder
      熊本大学、キッセイ薬品工業
    • Industrial Property Number
      2010-250367
    • Filing Date
      2010-11-09
    • Related Report
      2010 Final Research Report
  • [Patent(Industrial Property Rights)] アセトアミノフェン肝傷害治療剤2010

    • Inventor(s)
      石塚洋一, ほか
    • Industrial Property Rights Holder
      熊本大学キッセイ薬品
    • Industrial Property Number
      2010-250367
    • Filing Date
      2010-11-09
    • Related Report
      2010 Annual Research Report

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Published: 2009-04-01   Modified: 2016-04-21  

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