• Search Research Projects
  • Search Researchers
  • How to Use
  1. Back to previous page

Assessment of the efficacy of collagen-coated-bead columns for antiplatelet therapy in clinical settings

Research Project

Project/Area Number 21790532
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeSingle-year Grants
Research Field Laboratory medicine
Research InstitutionThe University of Tokyo

Principal Investigator

KANEKO Makoto  東京大学, 医学部附属病院, 助教 (00377491)

Project Period (FY) 2009 – 2010
Project Status Completed (Fiscal Year 2010)
Budget Amount *help
¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000)
Fiscal Year 2010: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2009: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Keywords血小板機能検査 / 抗血小板薬 / コラーゲンビーズカラム / 薬効モニタリング / 抗血小板剤
Research Abstract

In this study, we evaluated the utility of 2 types of collagen-coated-bead columns in the assessment of platelet function associated with the efficacy of antiplatelet drug therapy and prediction of bleeding. In particular, platelet activity was measured to diagnose whether patients with thrombotic disease were drug resistant and to assess patients who were or were not administered antiplatelet agents before endoscopic biopsy.
Large variation in the platelet retention rate among healthy individuals was observed using the collagen-coated-bead column; this may reflect individual differences but not methodological variability. Overlapping of the retention rates of patients who were and were not administered the antiplatelet reagents may limit the establishment of reference intervals for platelet function in the present assay system. However, the platelet retention rate may reflect individual variability in response to the antiplatelet drugs and may be useful for monitoring the efficacy of antiplatelet therapy in the same individual. Thus, it is important to evaluate platelet function before and after medication for monitoring the effects of antiplatelet drugs. We also evaluated platelet function by using light-transmission platelet aggregometer and whole-blood aggregometer with a screen filtration pressure method. Platelet function assays are not interchangeable and may vary on the basis of the assay used. These findings suggest that the platelet function assay needs to be used in suitable methods and to be evaluated for additional verification of its clinical utility.

Report

(3 results)
  • 2010 Annual Research Report   Final Research Report ( PDF )
  • 2009 Annual Research Report
  • Research Products

    (12 results)

All 2012 2011 2009 Other

All Journal Article (6 results) (of which Peer Reviewed: 2 results) Presentation (2 results) Book (1 results) Remarks (3 results)

  • [Journal Article] Evaluation of safety of endoscopic biopsy without cessation of antithrombotic agents in Japan2012

    • Author(s)
      Ono S, Fujishiro M, Kodashima S, Takahashi Y, Minatsuki C, Mikami-Matsuda R, Asada-Hirayama I, Konno-Shimizu M, Tsuji Y, Mochizuki S, Niimi K, Yamamichi N, Kaneko M, Yatomi Y, Koike K.
    • Journal Title

      J Gastroenterol.

      Volume: (Epub ahead of print)

    • NAID

      10030962124

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Evaluation of safety of endoscopic biopsy without cessation of antithrom botic agents in Japan2012

    • Author(s)
      Ono S, Fujishiro M, Kodashima S, Takahashi Y, Minatsuki C, Mikami-Matsuda R, Asada-Hirayama I, Konno-Shimizu M, Tsuji Y, Mochizuki S, Niimi K, Yamamichi N, Kaneko M, Yatomi Y, Koike K
    • Journal Title

      J Gastroenterol

      Volume: (Epub ahead of print)

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 抗血小板薬に対する反応多様性2011

    • Author(s)
      金子誠
    • Journal Title

      日本検査血液学会雑誌

      Volume: 12 Pages: 153-160

    • Related Report
      2010 Annual Research Report
  • [Journal Article] 抗血小板薬に対する反応多様性2009

    • Author(s)
      金子誠
    • Journal Title

      日本検査血液学会雑誌

      Volume: 34巻 Pages: 207-210

    • Related Report
      2010 Final Research Report
  • [Journal Article] 血液領域におけるピットフォール 血小板凝集能検査法の標準化 現状と問題点2009

    • Author(s)
      金子誠, 佐藤金夫, 尾崎由基男
    • Journal Title

      日本臨床検査自動化学会会誌

      Volume: 34巻 Pages: 207-210

    • Related Report
      2009 Annual Research Report
  • [Journal Article] 血小板関連疾患 血小板機能異常症の診断と対応2009

    • Author(s)
      金子誠, 矢冨裕
    • Journal Title

      日本血栓止血学会誌

      Volume: 20巻 Pages: 487-494

    • Related Report
      2009 Annual Research Report
  • [Presentation] 血小板・凝固検査2011

    • Author(s)
      金子誠
    • Organizer
      第9回日本検査血液学会 冬季セミナー
    • Place of Presentation
      山梨県笛吹市石和町
    • Year and Date
      2011-02-20
    • Related Report
      2010 Final Research Report
  • [Presentation] 血小板・凝固検査2011

    • Author(s)
      金子誠
    • Organizer
      第9回日本検査血液学会冬季セミナー
    • Place of Presentation
      山梨県笛吹市石和町
    • Year and Date
      2011-02-20
    • Related Report
      2010 Annual Research Report
  • [Book] わかりやすい血栓と止血の臨床2011

    • Author(s)
      金子誠, 矢冨裕
    • Publisher
      南江堂
    • Related Report
      2010 Annual Research Report
  • [Remarks]

    • URL

      http://lab-tky.umin.jp/achievements/index.html

    • Related Report
      2010 Final Research Report
  • [Remarks]

    • URL

      http://lab-tky.urain.jp/achievements/index.html

    • Related Report
      2010 Annual Research Report
  • [Remarks]

    • URL

      http://lab-tky.umin.jp/achievements/index.html

    • Related Report
      2009 Annual Research Report

URL: 

Published: 2009-04-01   Modified: 2016-04-21  

Information User Guide FAQ News Terms of Use Attribution of KAKENHI

Powered by NII kakenhi