| Budget Amount *help |
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2010: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2009: ¥2,600,000 (Direct Cost: ¥2,000,000、Indirect Cost: ¥600,000)
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| Research Abstract |
We found that the expression of WT1 was suppressed in Doxorubicin (Dox)-induced apoptosis in a concentration-dependent manner. Cloning of small RNAs expressed in DOX-treated gastric cancer cells revealed twenty-two miRNAs that increased in their expression levels during this process. Among them, we identified miR-A as a miRNA that could target WT1 and regulate apoptosis. Moreover, we showed that the expression of miR-A could be a prognostic factor for non-small cell lung cancers.
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