Glycan ligands of killer lectin-like receptors and regulation of NK functions
| Project/Area Number | 21790544 |
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Laboratory medicine
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| Research Institution | Toho University |
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Principal Investigator |
HIGAI Koji Toho University, 薬学部, 講師 (70297711)
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| Project Period (FY) |
2009 – 2010
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| Project Status |
Completed(Fiscal Year 2010)
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| Budget Amount *help |
¥4,290,000 (Direct Cost : ¥3,300,000、Indirect Cost : ¥990,000)
Fiscal Year 2010 : ¥1,820,000 (Direct Cost : ¥1,400,000、Indirect Cost : ¥420,000)
Fiscal Year 2009 : ¥2,470,000 (Direct Cost : ¥1,900,000、Indirect Cost : ¥570,000)
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| Keywords | NK細胞 / Killer LRs / NCRs / sialyl Lewis X / sialyl lewis X / heparin / NKG2D / NCR / 糖鎖リガンド / CD94 / Lectin / Polysaccharides |
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| Research Abstract |
Using recombinant extracellular lectin-like domains of KLRs (rKLRs) and NCRs (rNCRs) on NK cells, we evaluated their ligands specificity and binding affinities. Our data resulted that rKLRs and rNCRs can bind to sialyl Lewis X, GAGs and sulfated polysaccharides.
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Report
(3results)
Research Products
(46results)
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[Presentation] NCR1の糖鎖リガンドの解析2011
Author(s)
松本宏治郎、櫻井瑞葉、伊藤健一郎、桧貝孝慈
Organizer
第131回日本薬学会年会
Place of Presentation
(震災により、DVD・冊子による発表)
Year and Date
2011-03-30
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