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Analysis of a potential target at SCD-1, catalytic enzyme of fatty acid, for the prevention of cardiovascular disease.

Research Project

Project/Area Number 21790548
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeSingle-year Grants
Research Field Hygiene
Research InstitutionGunma University

Principal Investigator

MATSUI Hiroki  Gunma University, 医学部, 助教 (20431710)

Project Period (FY) 2009 – 2010
Project Status Completed (Fiscal Year 2010)
Budget Amount *help
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2010: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2009: ¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000)
Keywords循環器・高血圧 / 脂質 / メタボリックシンドローム / 予防医学 / 内臓肥満 / 糖尿病 / 高遊離脂肪酸血症 / 心筋傷害 / 血管石灰化 / 飽和脂肪酸 / 脂肪酸触媒酵素 / 酸化ストレス / 心血管系疾患 / エネルギー代謝 / アポトーシス
Research Abstract

To evaluate the effect of high plasma levels of free fatty acid, which are observed in the patients with obesity or diabetes, and catalytic enzyme of fatty acid on the onset of cardiovascular disease, we examined several basic analyses. As a result, we identified that saturated-fatty acids adversely affect the cardiovascular disease, and stearoyl-coA desaturase-1 (SCD-1), a catalytic enzyme which converts saturated fatty acids to monounsaturated fatty acids, has a protective role against saturated-fatty acids-induced these effects. In conclusions, our results demonstrated that SCD-1 as the novel preventive and therapeutic target for cardiovascular disease in obese or diabetic patients.

Report

(3 results)
  • 2010 Annual Research Report   Final Research Report ( PDF )
  • 2009 Annual Research Report
  • Research Products

    (28 results)

All 2011 2010 2009 Other

All Journal Article (9 results) (of which Peer Reviewed: 8 results) Presentation (19 results)

  • [Journal Article] Hypoxia-inducible factor-1α mediates TGFβ1-induced PAI-1 production in alveolar macrophages in pulmonary fibrosis.2011

    • Author(s)
      Ueno M, Matsui H, 他9名
    • Journal Title

      In press. Am.J.Physiol.(有)

    • Related Report
      2010 Final Research Report
  • [Journal Article] Hypoxia-inducible factor-1α mediates TGFβ1-induced PAI-1 production in alveolar macrophages in pulmonary fibrosis2011

    • Author(s)
      Ueno M, Matsui H, et al.
    • Journal Title

      Am.J.Physiol.

      Volume: (In press)

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Notch induces myofibroblast differentiation of alveolar epithelial cells.2010

    • Author(s)
      Aoyagi-Ikeda K, Matsui H, 他11名
    • Journal Title

      Am.J.Respir.Cell Mol.Biol. In press.

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Fibroblast Growth Factor 2 Induces Osteogenic Differentiation through a Runx2 Activation in Vascular Smooth Muscle Cells.2010

    • Author(s)
      Nakahara T, Matsui H, 他8名
    • Journal Title

      Biochem Biophys Res Commun. 394(2)

      Pages: 243-248

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Fibroblast Growth Factor 2 Induces Osteogenic Differentiation through a Runx2 Activation in Vascular Smooth Muscle Cells2010

    • Author(s)
      Nakahara T, Matsui H, et al.
    • Journal Title

      Biochem Biophys Res Commun.

      Volume: 394(2) Pages: 243-8

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Notch induces myofibroblast differentiation of alveolar epithelial cells.2010

    • Author(s)
      Kana Aoyagi-Ikeda, Matsui H, et al.
    • Journal Title

      Am.J.Respir.Cell Mol.Biol.

      Volume: (In press)

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] A new oxidative stress marker, N epsilon-(hexanoyl) lysine (HEL) is increased in metabolic syndrome, but not in obstructive sleep apnea.2009

    • Author(s)
      Tokuda F, Matsui H, 他2
    • Journal Title

      Am J Med Sci. 338(2)

      Pages: 127-133

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] A new oxidative stress marker, N epsilon-(hexanoyl)lysine(HEL)is increased in metabolic syndrome, but not in obstructive sleep apnea2009

    • Author(s)
      Tokuda F, Matsui H, et al.
    • Journal Title

      Am J Med Sci. 338(2)

      Pages: 127-33

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Fibroblast Growth Factor 2 Induces Osteogenic Differentiation througha Runx2 Activation in Vascular Smooth Muscle Cells

    • Author(s)
      Nakahara T, Matsui H, et al.
    • Journal Title

      Biochem Biophys Res Commun (In press)

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Presentation] 遊離脂肪酸触媒酵素Elovl6 は脱分化平滑筋細胞において細胞増殖に抑制的に働く2010

    • Author(s)
      須永浩章、松井弘樹
    • Organizer
      第17回日本未病システム学会
    • Place of Presentation
      沖縄
    • Year and Date
      2010-11-13
    • Related Report
      2010 Final Research Report
  • [Presentation] 血管石灰化の予防における遊離脂肪酸触媒酵素Elovl6 の病態意義の解明2010

    • Author(s)
      松井弘樹
    • Organizer
      第17回日本未病システム学会
    • Place of Presentation
      沖縄
    • Year and Date
      2010-11-13
    • Related Report
      2010 Final Research Report
  • [Presentation] 血管石灰化の予防における遊離脂肪酸触媒酵素Elovl6の病態意義の解明2010

    • Author(s)
      松井弘樹, 他
    • Organizer
      第17回日本未病システム学会
    • Place of Presentation
      沖縄県男女共同参画センター「てぃるる」(沖縄県)
    • Year and Date
      2010-11-13
    • Related Report
      2010 Annual Research Report
  • [Presentation] 遊離脂肪酸触媒酵素Elovl6は脱分化平滑筋細胞において細胞増殖に抑制的に働く2010

    • Author(s)
      須永浩章、松井弘樹, 他
    • Organizer
      第17回日本未病システム学会
    • Place of Presentation
      沖縄県男女共同参画センター「てぃるる」(沖縄県)
    • Year and Date
      2010-11-13
    • Related Report
      2010 Annual Research Report
  • [Presentation] Elevated Stearoyl-CoA Desaturase-1 Expression In Obese and Diabetic Heart Plays A Protective Role Against Fatty Acid-Induced Cardiac dysfunction.2010

    • Author(s)
      Matsui H.
    • Organizer
      第10回国際心臓研究学会
    • Place of Presentation
      京都
    • Year and Date
      2010-05-16
    • Related Report
      2010 Final Research Report
  • [Presentation] Stearoyl-CoA desaturase-1 has a protective effect against saturated fatty acids-induced osteogenic differentiation and apoptosis in vascular smooth muscle cells.2010

    • Author(s)
      Matsui H.
    • Organizer
      第10回国際心臓研究学会
    • Place of Presentation
      京都
    • Year and Date
      2010-05-16
    • Related Report
      2010 Final Research Report
  • [Presentation] Elevated Stearoyl-CoA Desaturase-1 Expression In Obese and Diabetic Heart Plays A Protective Role Against Fatty Acid-Induced Cardiac dysfunction.2010

    • Author(s)
      松井弘樹, 他
    • Organizer
      XXth World Congress of the International Society for Heart Research 2010
    • Place of Presentation
      国立京都国際会館(京都府)
    • Year and Date
      2010-05-16
    • Related Report
      2010 Annual Research Report
  • [Presentation] Stearoyl-CoA desaturase-1 has a protective effect against saturated fatty acids-induced osteogenic differentiation and apoptosis in vascular smooth muscle cells2010

    • Author(s)
      松井弘樹, 他
    • Organizer
      XXth World Congress of the International Society for Heart Research 2010
    • Place of Presentation
      国立京都国際会館(京都府)
    • Year and Date
      2010-05-13
    • Related Report
      2010 Annual Research Report
  • [Presentation] Peroxisome proliferator activated receptor-alpha regulates transendothelial fatty acid transport in Capillary Endothelial Cells in Heart.2010

    • Author(s)
      品川雄士、松井弘樹
    • Organizer
      第74回日本循環器学会総会・学術集会
    • Place of Presentation
      京都
    • Year and Date
      2010-03-06
    • Related Report
      2010 Final Research Report
  • [Presentation] A New Oxidative Stress Marker, N epsilon-(hexanoyl)lysine(HEL)is increased in Metabolic Syndrome, but not in Obstructive Sleep Apnea2010

    • Author(s)
      徳田史恵、松井弘樹, 他
    • Organizer
      第74回日本循環器学会総会・学術集会
    • Place of Presentation
      国立京都国際会館(京都府)
    • Year and Date
      2010-03-06
    • Related Report
      2009 Annual Research Report
  • [Presentation] Peroxisome proliferator activated receptor-alpha regulates trans endothelial fatty acid transport in Capillary Endothelial Cells in Heart2010

    • Author(s)
      品川雄士、松井弘樹, 他
    • Organizer
      第74回日本循環器学会総会・学術集会
    • Place of Presentation
      国立京都国際会館(京都府)
    • Year and Date
      2010-03-06
    • Related Report
      2009 Annual Research Report
  • [Presentation] Palmitic Acid Induces Osteogenic Differentiation of Vascular Smooth Muscle Cells.2010

    • Author(s)
      影山藍子、松井弘樹
    • Organizer
      第74回日本循環器学会総会・学術集会
    • Place of Presentation
      京都
    • Year and Date
      2010-03-05
    • Related Report
      2010 Final Research Report
  • [Presentation] A New Oxidative Stress Marker, N epsilon-(hexanoyl) lysine (HEL) is Increased in Metabolic Syndrome, but not in Obstructive Sleep Apnea2010

    • Author(s)
      徳田史恵、松井弘樹
    • Organizer
      第74回日本循環器学会総会・学術集会
    • Place of Presentation
      京都
    • Year and Date
      2010-03-05
    • Related Report
      2010 Final Research Report
  • [Presentation] Palmitic Acid Induces Osteogenic Differentiation of Vascular Smooth Muscle Cells : Involvement of ACSL3 and NF-kappa ; B and Prevention by Eicosapentaenoic Acid2010

    • Author(s)
      影山藍子、松井弘樹, 他
    • Organizer
      第74回日本循環器学会総会・学術集会
    • Place of Presentation
      国立京都国際会館(京都府)
    • Year and Date
      2010-03-05
    • Related Report
      2009 Annual Research Report
  • [Presentation] 遊離脂肪酸および脂肪酸不飽和化酵素が血管石灰化に及ぼす病態意義の解明2010

    • Author(s)
      松井弘樹
    • Organizer
      群馬血管医学研究会
    • Place of Presentation
      群馬ロイヤルホテル(群馬県)
    • Year and Date
      2010-02-12
    • Related Report
      2009 Annual Research Report
  • [Presentation] 血管石灰化における飽和脂肪酸および脂肪酸不飽和化酵素SCD1の病態意義の解明2010

    • Author(s)
      松井弘樹
    • Organizer
      第3回EANTASY
    • Place of Presentation
      リーガロイヤルホテル東京(東京都)
    • Year and Date
      2010-02-06
    • Related Report
      2009 Annual Research Report
  • [Presentation] Increased Stearoyl-CoA Desaturase-1 Expression in Obese and Diabetic Heart Plays A Protective Role Against Fatty Acid-Induced Cardiac Dysfunction.2009

    • Author(s)
      Matsui H.
    • Organizer
      第82回アメリカ心臓学会・学術集会
    • Place of Presentation
      アメリカ(ニューオリンズ)
    • Year and Date
      2009-11-16
    • Related Report
      2010 Final Research Report
  • [Presentation] Increased Stearoyl-CoA Desaturase-1 Expression in Obese and Diabetic Heart Plays A Protective Role Against Fatty Acid-Induced Cardiac Dysfunction2009

    • Author(s)
      松井弘樹
    • Organizer
      第82回アメリカ心臓協会・学術集会
    • Place of Presentation
      オーランド(アメリカ)
    • Year and Date
      2009-11-16
    • Related Report
      2009 Annual Research Report
  • [Presentation] 血管石灰化における遊離脂肪酸および触媒酵素SCD1の病態意義に関する検討2009

    • Author(s)
      松井弘樹
    • Organizer
      群馬大学・秋田大学連携グローバルCOE 第3回若手研究者シンポジウム
    • Place of Presentation
      群馬大学(群馬県)
    • Year and Date
      2009-11-11
    • Related Report
      2009 Annual Research Report

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Published: 2009-04-01   Modified: 2016-04-21  

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