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Role of neutrophils on diagnosis of the severity in lung dysfunction following hemorrhagic shock

Research Project

Project/Area Number 21790615
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeSingle-year Grants
Research Field Legal medicine
Research InstitutionUniversity of Occupational and Environmental Health, Japan

Principal Investigator

SATO Hiroaki  University of Occupational and Environmental Health, Japan, 医学部, 講師 (50441845)

Project Period (FY) 2009 – 2010
Project Status Completed (Fiscal Year 2010)
Budget Amount *help
¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2010: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2009: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Keywords社会医学 / サイトカイン
Research Abstract

We examined the role of neutrophils on diagnosis of the severity in lung dysfunction by grading four groups of severity of bleeding in rats. As the amount of bleeding increased, the expression of mRNA for TNF-α and IL-1β in the lung tissue and the pulmonary serum levels of both cytokines increased progressively up to 5 hours, and the frequency of activated neutrophils increased likewise. The lung dysfunction indices serum lactic dehydrogenase-3 isozyme (LDH-3), partial pressure of arterial oxygen (PaO_2) and alveolar-arterial oxygen tension difference (A-aDO_2) in blood deteriorated as the amount of bleeding increased. The frequency of activated neutrophils in the lung correlated well with the LDH-3 level 5 hours after hemorrhagic shock. The present results demonstrate that the increases of the recruitment of neutrophils into the lung activated by proinflammatory cytokines are quantitatively related to progression of lung dysfunction following hemorrhagic shock.

Report

(3 results)
  • 2010 Annual Research Report   Final Research Report ( PDF )
  • 2009 Annual Research Report
  • Research Products

    (4 results)

All 2010 2009

All Journal Article (2 results) (of which Peer Reviewed: 2 results) Presentation (2 results)

  • [Journal Article] A quantitative study of lung dysfunction following hemorrhagic shock in rats.2010

    • Author(s)
      H Sato, T Tanaka, T Kita, N Tanaka.
    • Journal Title

      International journal of experimental pathology 91

      Pages: 267-275

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] A quantitative study of lung dysfunction following hemorrhagic shock in rats2010

    • Author(s)
      Hiroaki Sato
    • Journal Title

      International Journal of Experimental Pathology

      Volume: 91巻 Pages: 267-275

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Presentation] 出血性ショック時の肺障害の重症度判定における好中球の評価2009

    • Author(s)
      佐藤寛晃, 山口裕樹, 笠井謙多郎, 田中敏子, 北敏郎, 田中宣幸
    • Organizer
      第93次日本法医学会総会
    • Place of Presentation
      大阪
    • Year and Date
      2009-05-14
    • Related Report
      2010 Final Research Report
  • [Presentation] 出血性ショック時の肺障害の重症度判定における好中球の評価2009

    • Author(s)
      佐藤寛晃
    • Organizer
      第93次日本法医学会学術全国集会
    • Place of Presentation
      大阪(千里ライフセンター)
    • Year and Date
      2009-05-14
    • Related Report
      2009 Annual Research Report

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Published: 2009-04-01   Modified: 2016-04-21  

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