Development of detection of methylation of multiple tumor suppressor genes and its clinical application.
Project/Area Number |
21790664
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Research Category |
Grant-in-Aid for Young Scientists (B)
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Allocation Type | Single-year Grants |
Research Field |
Gastroenterology
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Research Institution | Kyoto University |
Principal Investigator |
IDA Hiroshi Kyoto University, 医学研究科, 助教 (90437294)
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Project Period (FY) |
2009 – 2010
|
Project Status |
Completed (Fiscal Year 2010)
|
Budget Amount *help |
¥3,510,000 (Direct Cost: ¥2,700,000、Indirect Cost: ¥810,000)
Fiscal Year 2010: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2009: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
|
Keywords | RUNX3 / DNAメチル化 / 膵液 / 胆汁 / 膵液・胆汁 |
Research Abstract |
Detection of methylation of RUNX3 in bile juice was developed. Expression of RUNX3 in bile duct cancer cells was restored by the treatment with a new histone deacethylase inhibitor. Anti-tumor effect by the drug was revealed. Analysis of RUNX3 histone acethylation as well as DNA methylation can be a prognostic marker of bile duct cancer.
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Report
(3 results)
Research Products
(8 results)
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[Journal Article] RUNX3 promoter methylation in colorectal cancer : its relationship with microsatellite instability and its suitability as a nobel serum tumor marker.2010
Author(s)
Nishio M, SakakuraC, Nagata T, Komiyama S, Miyasahita A, Hamada T, Kuryu Y, Ikoma H, Kubota T, Kimura A, Nakanishi M, Ichikawa D, Fujiwara H, Okamoto K, Ochiai T, Kokuba Y, Sonoyama T, Ida H, Ito K, Chiba T, Ito Y, Otsuji E
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Journal Title
Anticancer Research Vol30
Pages: 2673-2682
Related Report
Peer Reviewed
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[Journal Article] RUNX3 promoter methylation in colorectal cancer : its relationship with microsatellite instability and its suitability as a nobel serum tumor marker.2010
Author(s)
Nishio M, Sakakura C, Nagata T, Komiyama S, Miyasahita A, Hamada T, Kuryu Y, Ikoma H, Kubota T, Kimura A, Nakanishi M, Ichikawa D, Fujiwara H, Okamoto K, Ochiai T, Kokuba Y, Sonoyama T, Ida H, Ito K, Chiba T, Ito Y, Otsuji E
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Journal Title
Anticancer Research
Volume: 30
Pages: 2673-2682
Related Report
Peer Reviewed
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[Journal Article] Quantitative analysis of tumor-derived methylated RUNX3 sequences in the serum of gastric cancer patients.2009
Author(s)
Sakakura C, Hamada T, Miyagawa K, Nishio M, Miyashita A, Nagata H, Ida H, Yazumi S, Otsuji E, Chiba T, Ito K, Ito Y.
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Journal Title
Anticancer Research Vol29
Pages: 2619-2625
Related Report
Peer Reviewed
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[Journal Article] Quantitative analysis of tumor-derived methylated RUNX3 sequences in the serum of gastric cancer patients.2009
Author(s)
Sakakura C, Hamada T, Miyagawa K, Nishio M, Miyashita A, Nagata H, Ida H, Yazumi S, Otsuji E, Chiba T, Ito K, Ito Y.
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Journal Title
Anticancer Research 29
Pages: 2619-2625
Related Report
Peer Reviewed
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