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Investigation of the effect of retinoids on hepatic iron overload in a mouse NAFLD model.

Research Project

Project/Area Number 21790666
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeSingle-year Grants
Research Field Gastroenterology
Research InstitutionKyoto Pharmaceutical University (2010)
Tottori University (2009)

Principal Investigator

TSUCHIYA Hiroyuki  Kyoto Pharmaceutical University, 薬学部, 講師 (00403402)

Project Period (FY) 2009 – 2010
Project Status Completed (Fiscal Year 2010)
Budget Amount *help
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2010: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Fiscal Year 2009: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
Keywordsレチノイン酸 / 鉄代謝 / NAFLD / インスリン抵抗性 / 肝鉄過剰沈着 / NASH / レプチン / 肝脂肪沈着
Research Abstract

Hepatic iron overload in non-alcoholic fatty liver disease (NAFLD) patients with steatosis and insulin resistance has been frequently observed in clinical settings. In this study, I found the close association between the iron overload and aberrant lipid deposition in the liver. Since I have previously clarified that retinoids have a potent effect on the hepatic iron metabolism, the pathological effect of a retinoid in mice with NAFLD was investigated. Consequently, the retinoid was found to markedly improve the insulin resistance in the mouse model in a leptin-dependent manner.

Report

(3 results)
  • 2010 Annual Research Report   Final Research Report ( PDF )
  • 2009 Annual Research Report
  • Research Products

    (17 results)

All 2010 Other

All Journal Article (5 results) (of which Peer Reviewed: 5 results) Presentation (6 results) Remarks (2 results) Patent(Industrial Property Rights) (4 results)

  • [Journal Article] Iron state in association with retinoid metabolism in non-alcoholic fatty liver disease2010

    • Author(s)
      土谷博之、他
    • Journal Title

      Hepatology Research 40

      Pages: 1227-1238

    • NAID

      10028172657

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] A close association of abnormal iron metabolism with steatosis in the mice fed a choline-deficient diet2010

    • Author(s)
      土谷博之、他
    • Journal Title

      Biological & Pharmaceutical Bulletin 33

      Pages: 1101-1104

    • NAID

      130000300270

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Iron state in association with retinoid metabolism in non-alcoholic fatty liver disease.2010

    • Author(s)
      土谷博之, 他
    • Journal Title

      Hepatol Res

      Volume: 40 Pages: 1227-1238

    • NAID

      10028172657

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] A close association of abnormal iron metabolism with steatosis in the mice fed a choline-deficient diet2010

    • Author(s)
      土谷博之, 他
    • Journal Title

      Biol Pharm Bull

      Volume: 33 Pages: 1101-1104

    • NAID

      130000300270

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Involvement of ETS1 in thioredoxin-binding protein 2 transcription induced by a synthetic retinoid CD437 in human osteosarcoma cells.2010

    • Author(s)
      橋口浩一、土谷博之, 他
    • Journal Title

      Biochem Biophys Res Commun

      Volume: 391 Pages: 621-626

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Presentation] レチノイン酸によるインスリン抵抗性改善作用メカニズムの解明2010

    • Author(s)
      土谷博之、他
    • Organizer
      第60回日本薬学会近畿支部総会・大会
    • Place of Presentation
      枚方
    • Year and Date
      2010-10-30
    • Related Report
      2010 Final Research Report
  • [Presentation] レチノイン酸によるインスリン抵抗性改善作用メカニズムの解明2010

    • Author(s)
      土谷博之, 他
    • Organizer
      第60回日本薬学会近畿支部総会
    • Place of Presentation
      枚方
    • Year and Date
      2010-10-30
    • Related Report
      2010 Annual Research Report
  • [Presentation] レチノイドによるNAFLDモデルマウスのインスリン抵抗性改善作用2010

    • Author(s)
      土谷博之、他
    • Organizer
      第46回日本肝臓学会総会
    • Place of Presentation
      山形
    • Related Report
      2010 Annual Research Report 2010 Final Research Report
  • [Presentation] レチノイン酸によるインスリン抵抗性改善作用:肝発癌抑制の一作用機序2010

    • Author(s)
      土谷博之、他
    • Organizer
      第69回日本癌学会学術総会
    • Place of Presentation
      大阪
    • Related Report
      2010 Annual Research Report 2010 Final Research Report
  • [Presentation] レチノイン酸によるレプチン依存的インスリン抵抗性改善作用2010

    • Author(s)
      土谷博之, 他
    • Organizer
      日本レチノイド研究会第21回学術集会
    • Place of Presentation
      大阪
    • Related Report
      2010 Annual Research Report
  • [Presentation] レチノイン酸による肝臓インスリン感受性増強メカニズム2010

    • Author(s)
      土谷博之, 他
    • Organizer
      第33会回日本分子生物学会年会(BMB2010)
    • Place of Presentation
      神戸
    • Related Report
      2010 Annual Research Report
  • [Remarks] ホームページ等

    • Related Report
      2010 Final Research Report
  • [Remarks]

    • URL

      http://www.kyoto-phu.ac.jp/labo/bukka/main.html

    • Related Report
      2010 Annual Research Report
  • [Patent(Industrial Property Rights)] レチノイン酸受容体リガンドによるインスリン抵抗性改善作用2010

    • Inventor(s)
      汐田剛史、土谷博之
    • Industrial Property Rights Holder
      国立大学法人鳥取大学
    • Industrial Property Number
      2010-093241
    • Filing Date
      2010-04-14
    • Related Report
      2010 Final Research Report
  • [Patent(Industrial Property Rights)] レチノイン酸受容体リガンドによるインスリン抵抗性改善作用2010

    • Inventor(s)
      汐田剛吏、土谷博之
    • Industrial Property Rights Holder
      国立大学法人鳥取大学
    • Industrial Property Number
      2010-093241
    • Filing Date
      2010-04-14
    • Related Report
      2010 Annual Research Report
  • [Patent(Industrial Property Rights)] レチノイン酸受容体リガンドの抗腫瘍作用、発癌抑制作用を含めた種々の作用を決定する遺伝子の同定2010

    • Inventor(s)
      汐田剛史、明地雄司、上田知紗、土谷博之
    • Industrial Property Rights Holder
      国立大学法人鳥取大学
    • Industrial Property Number
      2010-093226
    • Filing Date
      2010-04-14
    • Related Report
      2010 Annual Research Report
  • [Patent(Industrial Property Rights)] 5-FU単独及びIFN-α/5-FU併用時の抗腫瘍効果を増強する遺伝子群2010

    • Inventor(s)
      汐田剛史、土谷博之、坂部友彦
    • Industrial Property Rights Holder
      国立大学法人鳥取大学
    • Industrial Property Number
      2010-092869
    • Filing Date
      2010-04-14
    • Related Report
      2010 Annual Research Report

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Published: 2009-04-01   Modified: 2016-04-21  

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