Ribavirin regulates hepatitis C virus replication through the up-regulation of interferon-stimulated genes
| Project/Area Number |
21790670
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Gastroenterology
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| Research Institution | Ehime University |
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Principal Investigator |
TOKUMOTO Yoshio Ehime University, 医学部附属病院, 講師 (10533078)
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| Project Period (FY) |
2009 – 2010
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| Project Status |
Completed (Fiscal Year 2010)
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| Budget Amount *help |
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2010: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2009: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
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| Keywords | 肝臓学 / C型肝炎ウイルス / インターフェロン / リバビリン / Protein kinase R / Myxovirus resistance-A / 2'5'-oligoadenylate synthetase / インターフェロン誘導遺伝子 / PKR |
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| Research Abstract |
The combination therapy of interferon (IFN) and ribavirin (RBV) is used to treat HCV infection, however, how RBV enhances the anti-HCV effects remains unknown. We therefore investigated whether RBV modifies IFN's anti-HCV action. We used plasmid-based HCV replication system, which express HCV genotype 1a full genome in HepG2 and Huh7 hepatoma cell lines. Ribavirin regulates HCV replication through the up-regulation of ISGs induced by enhancing autocrine IFN-β. The modulation of ISGs by RBV would help to establish a means of eliminating HCV.
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Report
(3 results)
Research Products
(12 results)
