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Angiotensin II type 1 receptor antagonist prevents hepatic carcinoma in nonalcoholic steatohepatitis in rats

Research Project

Project/Area Number 21790687
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeSingle-year Grants
Research Field Gastroenterology
Research InstitutionAichi Medical University

Principal Investigator

NAKADE Yukiomi  Aichi Medical University, 医学部, 講師 (70431400)

Project Period (FY) 2009 – 2010
Project Status Completed (Fiscal Year 2010)
Budget Amount *help
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2010: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2009: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
Keywordsアンギオテンシン受容体拮抗剤 / NASH / 肝発癌予防 / コリン欠乏食 / 肝脂肪化 / 肝線維化
Research Abstract

To investigate whether angiotensin II receptor blocker could prevent the development of NASH related hepatocellular carcinoma (HCC), we examined the effect of ARB on choline-deficientL-aminoacid-defined (CDAA) diet NASH model. Twenty-four week-CDAA diet produced liver cirrhosis, and then CDAA diet for another 24 week aggravated liver cirrhosis, and produced HCC. On the other hand, telmisartan, a novel ARB, improved hepatic fibrosis and protected hepatic carcinogenesis even after 24-week CDAA diet feeding. These finding indicate that telmisartan has a therapeutic potential for NASH induced production of HCC even after hepatic fibrosis had been developed.

Report

(3 results)
  • 2010 Annual Research Report   Final Research Report ( PDF )
  • 2009 Annual Research Report
  • Research Products

    (24 results)

All 2010 2009 2008 2007 2006 2005 2003 2002 Other

All Journal Article (21 results) (of which Peer Reviewed: 21 results) Presentation (2 results) Remarks (1 results)

  • [Journal Article] Investigation and prediction of enteral nutrition problems after percutaneous endoscopic gastrostomy.2009

    • Author(s)
      Yokohama S, Aoshima M, Nakade Y, Shindo J, Maruyama J, Yoneda M.
    • Journal Title

      World J Gastroenterol 15

      Pages: 1367-1372

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Chronic restraint stress has no more stimulatory effects on colonic motility in rats.2009

    • Author(s)
      Masere C, Nakade Y, Zheng J, Babygirija R, Ludwig K, Takahashi T.
    • Journal Title

      Neurosci Lett 453

      Pages: 147-150

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Chronic restraint stress has no more stimulatory effects on colonic motility in rats2009

    • Author(s)
      Masere C, Nakade Y et al.
    • Journal Title

      Neuroscience Letter 453

      Pages: 147-150

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Investigation and prediction of enteral nutrition problems after percutaneous endoscopic gastrostomy2009

    • Author(s)
      Yokohama S, Aoshima M, Nakade Y et al.
    • Journal Title

      World Journal of Gastroenterology 21

      Pages: 1367-1372

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Daily intake of high dietary fiber slows accelerated colonic transit induced by restrain stress in rats.2008

    • Author(s)
      Takahashi T, Nakade Y, Fukuda H, Tsukamoto K, Mantyh C, Pappas TN.
    • Journal Title

      Dig Dis Sci 53

      Pages: 1271-1277

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Peripheralplasma corticotropin-releasing factor concentration does not correlate with augmented colonic motility in response to restraint stress in rats.2008

    • Author(s)
      Nakade Y, Pappas TN, Takahashi T.
    • Journal Title

      Clin Exp Pharmacol Physiol 35

      Pages: 934-937

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Ghrelin accelerates gastric emptying via early manifestation of antro-pyloric coordination in conscious rats.2008

    • Author(s)
      Ariga H, Nakade Y, Tsukamoto K, Imai K, Chen C, Mantyh C, Pappas TN, Takahashi T.
    • Journal Title

      Regul Pept 146

      Pages: 112-116

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Glucagon like peptide-1 accelerates colonic transit via central CRF and peripheral vagal pathways in conscious rats.2007

    • Author(s)
      Nakade Y, Tsukamoto K, Iwa M, Pappas TN, Takahashi T.
    • Journal Title

      Auton Neurosci 131

      Pages: 50-56

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Fecal pellet output does not always correlate with colonic transit in response to restraint stress and corticotropin-releasing factor in rats.2007

    • Author(s)
      Nakade Y, Mantyh C, Pappas TN, Takahashi T.
    • Journal Title

      J Gastroenterol 42

      Pages: 279-282

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Peripherally administered CRF stimulates colonic motility via central CRF receptors and vagal pathways in conscious rats.2006

    • Author(s)
      Tsukamoto K, Nakade Y, Mantyh C, Ludwig K, Pappas TN, Takahashi T.
    • Journal Title

      Am J Physiol Regul Integr Comp Physiol 290

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Central glucagon like peptide-1 delays solid gastric emptying via central CRF and peripheral sympathetic pathway in rats.2006

    • Author(s)
      Nakade Y, Tsukamoto K, Pappas TN, Takahashi T.
    • Journal Title

      Brain Res 1111

      Pages: 117-121

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Restraint stress augments postprandial gastric contractions but impairs antropyloric coordination in conscious rats.2006

    • Author(s)
      Nakade Y, Tsuchida D, Fukuda H, Iwa M, Pappas TN, Takahashi T.
    • Journal Title

      Am J Physiol Regul Integr Comp Physiol 290

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Restraint stress stimulates colonic motility via central corticotropin-releasing factor and peripheral 5-HT3 receptors in conscious rats.2006

    • Author(s)
      Nakade Y, Fukuda H, Iwa M, Tsukamoto K, Yanagi H, Yamamura T, Mantyh C, Pappas TN, Takahashi T.
    • Journal Title

      Am J Physiol Gastrointest Liver Physiol

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Electroacupuncture improves restraint stress-induced delay of gastric emptying via central glutaminergic pathways in conscious rats.2006

    • Author(s)
      Iwa M, Nakade Y, Pappas TN, Takahashi T.
    • Journal Title

      Neurosci Lett 399

      Pages: 6-10

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Electroacupuncture elicits dual effects : stimulation of delayed gastric emptying and inhibition of accelerated colonic transit induced by restraint stress in rats.2006

    • Author(s)
      Iwa M, Nakade Y, Pappas TN, Takahashi T.
    • Journal Title

      Dig Dis Sci 51

      Pages: 1493-1500

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Electroacupuncture at ST-36 accelerates colonic motility and transit in freely moving conscious rats.2006

    • Author(s)
      Iwa M, Matsushima M, Nakade Y, Pappas TN, Fujimiya M, Takahashi T.
    • Journal Title

      Am J Physiol Gastrointest Liver Physiol 290

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Effect of central corticotropin releasing factor on hepatic circulation in rats : the role of the CRF2 receptor in the brain.2005

    • Author(s)
      Yoneda M, Nakamura K, Nakade Y, Tamano M, Kono T, Watanobe H, Shimada T, Hiraishi H, Terano A.
    • Journal Title

      Gut 54

      Pages: 282-288

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Restraint stress delays solid gastric emptying via a central CRF and peripheral sympathetic neuron in rats.2005

    • Author(s)
      Nakade Y, Tsuchida D, Fukuda H, Iwa M, Pappas TN, Takahashi T.
    • Journal Title

      Am J Physiol Regul Integr Comp Physiol 288

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Electroacupuncture reduces rectal distension-induced blood pressure changes in conscious dogs.2005

    • Author(s)
      Iwa M, Strickland C, Nakade Y, Pappas TN, Takahashi T.
    • Journal Title

      Dig Dis Sci 50

      Pages: 1264-1270

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Central injection of astressin inhibits carbon tetrachloride-induced acute liver injury in rats.2003

    • Author(s)
      Nakade Y, Yoneda M, Yokohama S, Tamori K, Nakamura K, Watanobe H, Kono T, Makino I, Terano A.
    • Journal Title

      Eur J Pharmacol 460

      Pages: 135-138

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Involvement of endogenous CRF in carbon tetrachloride-induced acute liver injury in rats.2002

    • Author(s)
      Nakade Y, Yoneda M, Nakamura K, Makino I, Terano A.
    • Journal Title

      Am J Physiol Regul Integr Comp Physiol 282

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Presentation] アンギオテンシンII受容体拮抗剤によるNASH関連肝発癌の予防:HIF-1αと酸化ストレスとの関わり2010

    • Author(s)
      中出幸臣
    • Organizer
      日本肝臓学会総会
    • Place of Presentation
      山形国際ホテル
    • Year and Date
      2010-05-27
    • Related Report
      2010 Annual Research Report 2010 Final Research Report
  • [Presentation] NASH関連肝発癌に対するアンギオテンシン受容体拮抗剤による予防2009

    • Author(s)
      中出幸臣
    • Organizer
      日本肝臓学会西部会
    • Place of Presentation
      米子コンベンションセンター
    • Year and Date
      2009-12-02
    • Related Report
      2010 Final Research Report 2009 Annual Research Report
  • [Remarks] ホームページ等

    • Related Report
      2010 Final Research Report

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Published: 2009-04-01   Modified: 2016-04-21  

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