A role of Maf B in development and rupture of atherosclerotic plaques

• Project/Area Number: 21790700
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Single-year Grants
• Research Field: Circulatory organs internal medicine
• Research Institution: Yamagata University
• Principal Investigator: WATANABE Tetsu 山形大学, 医学部, 講師 (40359568)
• Project Period (FY): 2009 – 2011
• Project Status: Completed (Fiscal Year 2011)
• Budget Amount: ¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000); Fiscal Year 2011: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000); Fiscal Year 2010: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000); Fiscal Year 2009: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
• Keywords: 動脈硬化 / マクロファージ / プラーク破綻 / MafB

Research Abstract

There was no difference in development of atherosclerotic plaques between ApoE-/-and DN-MafB/ApoE-/-mice. However, more necrotic cores and fewer fibrous tissues were shown in atherosclerotic plaques in DN-MafB/ApoE-/-mice than in ApoE-/-mice. DN-MafB/ApoE-/-mice had more apoptotic macrophages and production of reactive oxygen species in the atherosclerotic plaques than ApoE-/-mice. DN-MafB may be associated with vulnerability of atherosclerotic plaques.

Research Products

• [Journal Article] Prognostic value of low left atrial appendage wall velocity in patients with ischemic stroke and atrial fibrillation (2012)
  • Author(s): Tamura H, Watanabe T, Nishiyama S, Sasaki S, Wanezaki M, Arimoto T, Takahashi H, Shishido T, Miyashita T, Miyamoto T, Kubota I
  • Journal Title: J Am Soc Echocardiogr Volume: 25 Pages: 576-583
  • URL: http://dx.doi.org/10.1016/j.echo.2012.01.012
  • Peer Reviewed
• [Journal Article] Prognostic Value of Low Left Atrial Appendage Wall Velocity in Patients with Ischemic Stroke and AtrialFibrillation (2012)
  • Author(s): Harutoshi Tamura
  • Journal Title: Journal of American Society of Echocardiography Volume: 25 Pages: 576-583
  • DOI: 10.1016/j.echo.2012.01.012
  • Peer Reviewed
• [Journal Article] Elevated cystatin C levels predict the incidence of vasospastic angina (2011)
  • Author(s): Funayama A, Watanabe T, Tamabuchi T, Otaki Y, Netsu S, Hasegawa H, Honda S, Ishino M, Arimoto T, Takahashi H, Shishido T, Miyamoto T, Nitobe J, Kubota I
  • Journal Title: Circ J Volume: 75 Pages: 2439-2444
  • NAID: 10029459648
  • URL: http://dx.doi.org/10.1253/circj.CJ-11-0008
  • Peer Reviewed
• [Journal Article] Increased left atrial volume index predicts a poor prognosis in patients with heart failure (2011)
  • Author(s): Tamura H, Watanabe T, Nishiyama S, Sasaki S, Arimoto T, Takahashi H, Shishido T, Miyashita T, Miyamoto T, Nitobe J, Hirono O, Kubota I
  • Journal Title: J Card Fail Volume: 17 Pages: 210-216
  • URL: http://dx.doi.org/10.1016/j.cafail.2010.10.006
  • Peer Reviewed
• [Journal Article] 8-Hydroxy-2'-deoxyguanosine is a prognostic mediator for cardiac event (2011)
  • Author(s): Suzuki S, Shishido T, Ishino M, Katoh S, Sasaki T, Nishiyama S, Miyashita T, Miyamoto T, Nitobe J, Watanabe T, Takeishi Y, Kubota I
  • Journal Title: Eur J Clin Invest Volume: 41 Pages: 759-766
  • URL: http://dx.doi.10.1111/j.1365-2362.2010.02465.x
  • Peer Reviewed
• [Journal Article] Serum pregnancy-associated plasma protein a in patients with heart failure (2011)
  • Author(s): Akira Funayama
  • Journal Title: J Card Fail. Volume: 17 Pages: 819-26
  • DOI: 10.1016/j.cardfail.2011.05.011
  • Peer Reviewed
• [Journal Article] Elevated Cystatin C Levels Predict the Incidence of Vasospastic Angina (2011)
  • Author(s): Akira Funayama
  • Journal Title: Circ J Volume: 75 Issue: 10 Pages: 2439-2439
  • DOI: 10.1253/circj.cj-11-0008 10.1253/circj.CJ-11-0008
  • NAID: 10029459648
  • ISSN: 1346-9843, 1347-4820
  • Peer Reviewed
• [Journal Article] Trends in coronary risk factors among patients with acute myocardial infarction over the last decade : the Yamagata AMI registry (2010)
  • Author(s): Nishiyama S, Watanabe T, Arimoto T, Takahashi H, Shishido T, Miyashita T, Miyamoto T, Nitobe J, Shibata Y, Konta T, Kawata S, Kato T, Fukao A, Kubota I
  • Journal Title: J Atheroscler Thromb Volume: 17 Pages: 989-998
  • NAID: 130004444462
  • URL: http://dx.doi.org/10.5551/jat.4671
  • Peer Reviewed
• [Journal Article] Trends in coronary risk factors among patients with acute myocardial infarction over the last decade : the Yamagata AMI registry. (2010)
  • Author(s): Nishiyama S, Watanabe T
  • Journal Title: J Atheroscler Thromb Volume: 17 Pages: 989-989
  • NAID: 130004444462
  • Peer Reviewed
• [Journal Article] Low wall velocity of left atrial appendage measured by trans-thoracic echocardiography predicts thrombus formation caused by atrial appendage dysfunction. (2010)
  • Author(s): Tamura H, Watanabe T
  • Journal Title: J Am Soc Echocardiogr. Volume: 23 Pages: 545-545
  • Peer Reviewed
• [Journal Article] Increased left atrial volume index predicts a poor prognosis in patients with heart failure. (2010)
  • Author(s): Tamura H, Watanabe T
  • Journal Title: J Card Fail Volume: 17 Pages: 210-210
  • Peer Reviewed
• [Journal Article] High serum level of neopterin is a risk factor of patients with heart failure (2010)
  • Author(s): Sasaki T, et al
  • Journal Title: Int J Cardiol
  • Peer Reviewed
• [Journal Article] High variability of albuminuria in nondiabetic population : the Takahata Study (2009)
  • Author(s): Suzuki K, et al
  • Journal Title: Clin Exp Nephrol 13 Pages: 452-452
  • Peer Reviewed
• [Presentation] Pentraxin 3 is essential for neointima formation after vascular injury (2012)
  • Author(s): Ishino M, Shishido T, Suzuki S, Katoh S, Sasaki T, Netsu S, Funayama A, Tamura H, Nishiyama S, Arimoto T, Takahashi H, Miyashita T, Miyamoto T, Watanabe T, Takeishi Y, Kubota I
  • Organizer: The 76th Annual Scientific Meeting of the Japanese Circulation Society
  • Place of Presentation: Fukuoka, Fukuoka International Congress Center
• [Presentation] Cardiac-specific overexpression of high mobility group box 1 (HMGB1) prevents cardiac dysfunction induced by pressure overload (2012)
  • Author(s): Funayama A, Shishido T, Ishino M, Ohtaki Y, Netsu S, Hasegawa H, Honda S, Kadowaki S, Narumi T, Nishiyama S, Arimoto T, Takiahashi H, Miyashita T, Miyamoto T, Watanabe T, Kubota I
  • Organizer: The 76th Annual Scientific Meeting of the Japanese Circulation Society
  • Place of Presentation: Fukuoka, Fukuoka International Congress Center
• [Presentation] Overexpression of midkine aggravates cardiac dysfunction and adverse myocardial remodeling induced by pressure overload (2012)
  • Author(s): Netsu S, Shishido T, Ishino M, Funayama A, Kadowaki S, Narumi T, Ohtaki Y, Hasegawa H, Honda S, Tamura H, Nishiyama S, Arimoto T, Takahashi H, Miyashita T, Miyamoto T, Watanabe T, Kubota I
  • Organizer: The 76th Annual Scientific Meeting of the Japanese Circulation Society
  • Place of Presentation: Fukuoka, Fukuoka International Congress Center
• [Presentation] The patients with multiple coronary risk fiactors have a great increase in recurrence risk of acute myocardial infarction (2012)
  • Author(s): Masahiro Wanezaki
  • Organizer: 第76回日本循環器学会学術集会
  • Place of Presentation: 福岡市 福岡国際会議場
• [Presentation] Deficiency of the long pentraxin PTX3 deteriorates neointimal hyperplasia after vascular injury (2011)
  • Author(s): Ishino M, Shishido T, Suzuki S, Katoh S, Sasaki T, Netsu S, Funayama A, Arimoto T, Nishiyama S, Takahashi H, Miyashita T, Miyamoto T, Watanabe T, Takeishi Y, Kubota I
  • Organizer: American Heart Association Scientific Sessions2011
  • Place of Presentation: Orlando, America ; November
• [Presentation] Midkine exacerbates cardiac hypertrophy and remodeling in response to pressure overload (2011)
  • Author(s): Netsu S, Shishido T, Ishino M, Kadowaki S, Narumi T, Otaki Y, Funayama A, Honda S, Hasegawa H, Nishiyama S, Takahashi H, Arimoto T, Miyashita T, Miyamoto T, Watanabe T, Kubota I
  • Organizer: American Heart Association Scientific Sessions 2011
  • Place of Presentation: Orlando, America
• [Presentation] Cardiac-specific overexpression of high mobility group box 1 (HMGB1) attenuates cardiac dysfunction induced by pressure overload (2011)
  • Author(s): Funayama A, Shishido T, Netsu S, Ishino M, Otaki Y, Honda S, Hasegawa H, Kadowaki S, Narumi T, Nishiyama S, Takahashi H, Arimoto T, Miyashita T, Miyamoto T, Watanabe T, Woo CH, Kuwahara K, Nakao K, Takeishi Y, Kubota I
  • Organizer: American Heart Association Scientific Sessions 2011
  • Place of Presentation: Orlando, America
• [Presentation] Feasibility of combined evaluation of brain natriuretic peptide and heart-type fatty acid binding protein in female patients with heart failure. (2010)
  • Author(s): Hasegawa H
  • Organizer: American Heart Association Scientific Sessions
  • Place of Presentation: Chicago, USA
  • Year and Date: 2010-11-13
• [Presentation] trial endothelial impairment through Toll-like receptor(TLR)-4 signaling may cause atrial thrombogenesis (2010)
  • Author(s): Katoh S, et al
  • Organizer: 第74回日本循環器学会学術総会
  • Place of Presentation: 京都
  • Year and Date: 2010-03-05
• [Presentation] Atrial endothelial impairment through toll-like receptor-4 signaling may cause atrial thrombogenesis (2010)
  • Author(s): Kato S, Watanabe T, Suzuki S, Ishino M, Sasaki T, Shishido T, Sadahiro M, Kubota I
  • Organizer: XXth World Congress of the International Society for Heart Research 2010
  • Place of Presentation: Kyoto ; Kyoto International Conference Center
• [Book] Brugada症候群.循環器疾患最新の治療 (2012)
  • Author(s): 渡邉哲, 久保田功
  • Publisher: 南江堂