Development of new strategy by manipulating autophagy against cardiac failure

• Project/Area Number: 21790714
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Single-year Grants
• Research Field: Circulatory organs internal medicine
• Research Institution: Gifu University
• Principal Investigator: KANAMORI Hiromitsu Gifu University, 医学部附属病院, 助教 (20456502)
• Project Period (FY): 2009 – 2010
• Project Status: Completed (Fiscal Year 2010)
• Budget Amount: ¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000); Fiscal Year 2010: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000); Fiscal Year 2009: ¥2,600,000 (Direct Cost: ¥2,000,000、Indirect Cost: ¥600,000)
• Keywords: 分子心臓病態学 / オートファジー / 心筋梗塞 / 慢性心不全 / 左室リモデリング / エネルギー代謝 / 飢餓 / 急性心筋梗塞 / 心機能 / 梗塞サイズ / ATG5siRNA / LAMP-2siRNA

Research Abstract

Starvation-induced autophagy compensated energy by digesting own constituents and maintained cardiac function. Autophagy emerged in acute myocardial infarction and suppressed cardiomyocyte death and limited infarct expansion. Autophagy protected progression of postinfarction cardiac remodeling and improved cardiac dysfunction. These present findings suggest that auophagy is innate and potent protective mechanism and augmenting autophagy could be a useful new therapeutic strategy for myocardial infarction.

Research Products

• [Journal Article] Autophagy limits acute myocardial infarction induced by permanent coronary artery occulusion. (2011)
  • Author(s): Kanamori H, Takemura G, Goto K, Maruyama R, Ono K, Nagao K, Tsujimoto A, Ogino A, Takeyama T, Kawaguchi T, Watanabe T, Kawasaki M, Fujiwara T, Fujiwara H, Seishima M, Minatoguch S.
  • Journal Title: Am J Phisiol Heart Circ Phisiol in press
  • Peer Reviewed
• [Journal Article] The role of emerging autophagy in postinfarction cardiac remodeling. (2011)
  • Author(s): Kanamori H, Takemura G, Goto K, Maruyama R, Tsujimoto A, Ogino A, Takeyama T, Kawaguchi T, Watanabe T, Fujiwara T, Fujiwara H, Seishima M, Minatoguchi S.
  • Journal Title: Cardiovascular Research in press
  • Peer Reviewed
• [Journal Article] Autophagy maintains cardiac function in the starved adult. (2009)
  • Author(s): Takemura G, Kanamori H, Goto K, Maruyama R, Tsujimoto A, Fujiwara H, Seishima M, Minatogichi S.
  • Journal Title: Autophagy 5(7) Pages: 1034-1036
  • Peer Reviewed
• [Journal Article] Functional significance and morphological characterization of starvation-induced autophagy in the adult heart. (2009)
  • Author(s): Kanamori H, Takemura G, Maruyama R, Goto K, Tsujimoto A, Ogino A, Li L, Kawamura I, Takeyama T, Kawaguchi T, Nagashima K, Fujiwara T, Fujiwara H, Seishima M, MInatoguchi S.
  • Journal Title: Am J Pathol 174 Pages: 1705-1714
  • Peer Reviewed
• [Journal Article] Functional significance and morphological characterization of starvation-induced autophagy in the adult heart. (2009)
  • Author(s): Kanamori H
  • Journal Title: American journal of pathology 174(5) Pages: 1705-1714
  • Peer Reviewed
• [Journal Article] Autophagy maintains cardiac function in the starved adult. (2009)
  • Author(s): Kanamori H, Takemura G
  • Journal Title: autophagy 5(1) Pages: 90-92
  • Peer Reviewed
• [Journal Article] (2009)
  • Author(s): 金森寛充
  • Journal Title: 分子血管病 12Vol.10 no.6 2009 10 Pages: 76-78
• [Presentation] Autophagy Limits Expansion of Acute Myocardial Infarction Induced by Permanent Coronary Artery Occlusion (2010)
  • Author(s): Hiromitsu Kanamori, Genzou Takemura, Rumi Maruyama, Kazuko Goto, Akiko Tsujimoto, Koh Ono, Kazuya Nagao, Atsushi Ogino, Itta Kawamura, Toshiaki Takeyama, Tomonori Kawaguchi, Takatomo Watanabe, Takako Fujiwara, Hisayoshi Fujiwara, Mitsuru Seishima, Shinya Minatoguchi
  • Organizer: 第14回日本心不全学会・学術集会
  • Place of Presentation: 東京
• [Presentation] 急性心筋梗塞におけるオートファジーのプロセスと心筋保護的役割 (2010)
  • Author(s): 金森寛充、竹村元三、清島満、湊口信也
  • Organizer: 第19回日本Cell Death学会学術集会
  • Place of Presentation: 名古屋
• [Presentation] Cardiomyocyte Autophagy is an Innate Protective Mechanism against Progression of Postinfarction Cardiac Remodeling (2010)
  • Author(s): Hiromitsu Kanamori, Genzou Takemura, Kazuko Goto, Rumi Maruyama, Akiko Tsujimoto, Itta Kawamura, Toshiaki Takeyama, Tomonori Kawaguchi, Takatomo Watanabe, Atsushi Ogino, Takako Fujiwara, Hisayoshi Fujiwara, Mitsuru Seishima, Shinya Minatoguchi
  • Organizer: 第74回日本循環器学会・学術集会
  • Place of Presentation: 京都
• [Presentation] Autophagy Limits Expansion of Acute Myocardial Infarction Induced by Permanent Coronary Artery Occlusion (2010)
  • Author(s): 金森寛充
  • Organizer: 第14回日本心不全学会
  • Place of Presentation: 東京
• [Presentation] 急性心筋梗塞におけるオートファジーのプロセスと心筋保護的役割 (2010)
  • Author(s): 金森寛充
  • Organizer: 第19回日本Cell Death学会
  • Place of Presentation: 名古屋
• [Presentation] Cardiomyocyte Autophagy is an Innate Protective Mechanism against Progression of Postinfarction Cardiac Remodeling (2010)
  • Author(s): 金森寛充
  • Organizer: 第74回日本循環器学会
  • Place of Presentation: 国立京都国際会館(京都)
• [Presentation] Autophagy Limits Acute Myocardial Infarct Expansion. (2009)
  • Author(s): Hiromitsu Kanamori, Genzou Takemura, Tomonori Kawaguchi, Toshiaki Takeyama, Itta Kawamura, Kazuko Goto, Longhu Li, Hisayoshi Fujiwara, Mitsuru Seishima, Shinya Minatoguchi
  • Organizer: 17th Asia Pacific Congress of Cardiology. 17^<th> APCC Kyoto Japan 2009
  • Place of Presentation: Kyoto, Japan
• [Remarks] ホームページ等