The role of Girdin, a new Akt substrate, in vascular homeostasis
| Project/Area Number |
21790715
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Circulatory organs internal medicine
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| Research Institution | Nagoya University |
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Principal Investigator |
MAEDA Kengo 名古屋大学, 医学部附属病院, 助教 (80456673)
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| Project Period (FY) |
2009-04-01 – 2013-03-31
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| Project Status |
Completed (Fiscal Year 2013)
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| Budget Amount *help |
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2012: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2011: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2010: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2009: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
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| Keywords | Girdin / 細胞骨格 / 細胞骨格制御 |
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| Research Abstract |
The expression of Girdin is found in endothelial cells and vascular smooth muscle cells. We previously found that the expression of Girdin and its Akt-mediated phosphorylation at serine 1416 ragulated the chemotaxis of endothelial cells and played an essential role in angiogenesis. We also found that Girdin formed a complex with R-Ras in mature endothelial cells, where Girdin regulated the intracellular trafficking of VE-cadherin. The results suggest that Girdin regulates transendothelial permmeability in synergy with R-Ras and VE-cadherin.
We additionally investigated the function of Girdin in vascular smooth muscle cells. The expression of Girdin and its Akt-mediated phosphorylation were involeved in the chemotaxis and cytokinesis of vascular smooth muscle cells. Both knockdown of Girdin and knock-in of alanine at serine 1416 attenuated the neointima formation after vascular injury. The results suggest that Girdin is essential for neointimal formation after vascular injury.
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Report
(5 results)
Research Products
(24 results)
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[Journal Article] The significance of measuring body fat percentage determined by bioelectrical impedance analysis for detecting subjects with cardiovascular disease risk factors2012
Author(s)
Yamashita K, Kondo T, Osugi S, Shimokata K, Maeda K, Okumura N, Matsudaira K, Shintani S, Muramatsu T, Matsushita K, Murohara T
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Journal Title
Circ J
Volume: 76(10)
Pages: 2435-42
NAID
Related Report
Peer Reviewed
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[Journal Article] Comparison between valsartan and amlodipine regarding cardiovascular morbidity and mortality in hypertensive patients with glucose intolerance : NAGOYA HEART Study2012
Author(s)
Muramatsu T, Matsushita K, Yamashita K, Kondo T, Maeda K, Shintani S, Ichimiya S, Ohno M, Sone T, Ikeda N, Watarai M, Murohara T; NAGOYA HEART Study Investigators
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Journal Title
Hypertension
Volume: 59(3)
Pages: 580-6
Related Report
Peer Reviewed
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[Journal Article] Smoking and smoking cessation in relation to all-cause mortality and cardiovascular events in 25, 464 healthy male Japanese workers2011
Author(s)
Kondo T, Osugi S, Shimokata K, Honjo H, Morita Y, Maeda K, Yamashita K, Muramatsu T, Shintani S, Matsushita K, Murohara T
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Journal Title
Circ J
Volume: 75(12)
Pages: 2885-92
NAID
Related Report
Peer Reviewed
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[Journal Article] Metabolic syndrome and all-cause mortality, cardiac events, and cardiovascular events : a follow-up study in 25, 471 young- and middle-aged Japanese men2011
Author(s)
Kondo T, Osugi S, Shimokata K, Honjo H, Morita Y, Yamashita K, Maeda K, Muramatsu T, Shintani S, Matsushita K, Murohara T
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Journal Title
Eur J Cardiovasc Prev Rehabil
Volume: 18(4)
Pages: 574-80
Related Report
Peer Reviewed
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[Journal Article] The actin-binding protein Girdin and its Akt-mediated phosphorylation regulate neointima formation after vascular injury2011
Author(s)
Miyake H, Maeda K, Asai N, Shibata R, Ichimiya H, Isotani-Sakakibara M, Yamamura Y, Kato K, Enomoto A, Takahashi M, Murohara T
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Journal Title
Circ Res
Volume: 108(10)
Pages: 1170-9
Related Report
Peer Reviewed
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[Journal Article] Protective role of Gipie, a Girdin family protein, in endoplasmic reticulum stress responses in endothelial cells2011
Author(s)
Matsushita E, Asai N, Enomoto A, Kawamoto Y, Kato T, Mii S, Maeda K, Shibata R, Hattori S, Hagikura M, Takahashi K, Sokabe M, Murakumo Y, Murohara T, Takahashi M
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Journal Title
Mol Biol Cell
Volume: 22(6)
Pages: 736-47
Related Report
Peer Reviewed
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