| Project/Area Number |
21790719
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Circulatory organs internal medicine
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| Research Institution | Kyoto University |
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Principal Investigator |
USAMI Satoru Kyoto University, 医学研究科, 医員 (30521752)
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| Project Period (FY) |
2009 – 2010
|
| Project Status |
Completed (Fiscal Year 2010)
|
| Budget Amount *help |
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2010: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Fiscal Year 2009: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
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| Keywords | 心筋リモデリング / 遺伝子転写調節 / アンジオテンシンII |
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| Research Abstract |
In this study, we evaluated roles played by myocardin-related transcription factor-A (MRTF-A), a co-activator of serum response factor (SRF), in pathological cardiac remodeling. Mechanical stress and neurohumoral stimulation onto cardiac myocytes induced nuclear translocation of MRTF-A, a co-activator of serum response factor (SRF) in a Rho and actin dynamics-dependent manner, thereby activating SRF. Our findings define the Rho- and actin dynamics-dependent nuclear translocation of MRTF-A as a novel common signaling mechanism underlying both mechanical stretch- and neurohumoral stimulation-induced cardiac hypertrophy and fetal gene activation during pathological cardiac remodeling.
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