Development of Multicenter Registry of Percutaneous Coronary Intervention for International Comparison and Quality Improvement

• Project/Area Number: 21790751
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Single-year Grants
• Research Field: Circulatory organs internal medicine
• Research Institution: Keio University
• Principal Investigator: KOHSAKA Shun Keio University, 医学部, 助教 (30528659)
• Project Period (FY): 2009 – 2010
• Project Status: Completed (Fiscal Year 2010)
• Budget Amount: ¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000); Fiscal Year 2010: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000); Fiscal Year 2009: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
• Keywords: 循環器 / 高血圧 / 循環器・高血圧 / 内科 / 社会学 / 社会医学

Research Abstract

In the present study, we successfully registered 4150 patients from 15 centers. We first calculated bleeding complication rate (defined drop of Hg of more than 3g/dl) and generated statistical model to quantify the associated clinical variables. The bleeding complication rate was observed in 6% of our patients, which was significantly higher compared to the Western patients. Comorbidities such as hemodyalisis, or acute presentation such as acute coronary syndrome (ACS) were associated with higher risk of bleeding. Second, we calculated prescription rate of guideline-recommended secondary prevention agents and noted some medications, such as beta-blockers or ACE/ARBs are dispensed less compared to others. Lastly, we compared the outcome of ACS patients admitted on weekdays with those admitted on weekend. The results of these studies have been presented in Japanese Society of Cardiology annual meeting and manuscripts are submitted to peer-review journals. Further, we are currently providing feedbacks to each participating sites and aim to quantify its long-term contribution to improved outcome.

Research Products

• [Journal Article] Arterial wave reflection and subclinical left ventricular systolic dysfunction. (2011)
  • Author(s): Russo C, Jin Z, Takei Y, Hasegawa T, Koshaka S, Palmieri V, Elkind MSHomma S, Sacco RL, Di Tullio MR.
  • Journal Title: J Hypertens. 29(3) Pages: 574-582
  • Peer Reviewed
• [Journal Article] Elevated inflammatory markers in heart failure patients with lower BMI. (2011)
  • Author(s): Banno A, Kohsaka S, Yoshikawa T.
  • Journal Title: J Card Fail. 17(3) No abstract available. Pages: 264-264
  • Peer Reviewed
• [Journal Article] Elevated inflammatory markers in heart failure patients with lower BMI. (2011)
  • Author(s): Banno A, Kohsaka S, Yoshikawa T.
  • Journal Title: J Card Fail Volume: 17 Pages: 264-264
  • Peer Reviewed
• [Journal Article] Arterial wave reflection and subclinical left ventricular systolic dysfunction. (2011)
  • Author(s): Russo C, Jin Z, Takei Y, Hasegawa T, Koshaka S, Palmieri V, Elkind MSHomma S, Sacco RL, Di Tullio MR
  • Journal Title: J Hypertens Volume: 29 Pages: 574-582
  • Peer Reviewed
• [Journal Article] Elevated B-type natriuretic peptide level as a marker of subsequent thromboembolic events in patients with atrial fibrillation. (2010)
  • Author(s): Sadanaga T, Kohsaka S, Mitamura H, Ogawa S.
  • Journal Title: Heart Vessels. [Epub ahead of print]
  • Peer Reviewed
• [Journal Article] D-dimer levels in combination with clinical risk factors can effectively predict subsequent thromboembolic events in patients with atrial fibrillation during oral anticoagulant therapy. (2010)
  • Author(s): Sadanaga T, Kohsaka S, Ogawa S.
  • Journal Title: Cardiology. 117(1) Pages: 31-36
  • Peer Reviewed
• [Journal Article] Relationship between Serum Lipid Values and Atherosclerotic Burden in the Proximal Thoracic Aorta. (2010)
  • Author(s): Kohsaka S, Sacco RL, Jin Z, Liu R, Rundek T, Boden-Albala B, Homma S, Di Tullio MR.
  • Journal Title: Int J Stroke. 5(4) Pages: 257-263
  • Peer Reviewed
• [Journal Article] Difference in Patient Profiles and Outcomes in Japanese Versus American Patients Undergoing Coronary Revascularization : A Collaborative Study by CREDO-Kyoto and the Texas Heart Institute Research Database. (2010)
  • Author(s): Kohsaka S, Kimura T, Goto M, Lee VV, Elayda MA, Furukawa Y, Fukushima M, Komeda M, Sakata R, Willerson, JT, Wilson, JM, Kita T.
  • Journal Title: Am J Cordial. 105(12) Pages: 1698-1704
  • Peer Reviewed
• [Journal Article] Ogawa Elevated troponin T on discharge predicts poor outcome of decompensated heart failure. (2010)
  • Author(s): Koide K, Yoshikawa T, Nagatomo Y, Kohsaka S, Anzai T, Meguro T
  • Journal Title: Heart Vessels. 25(3) Pages: 217-222
  • Peer Reviewed
• [Journal Article] J-RHYTHM Investigators. Impact of drug alteration to maintain rhythm control in paroxysmal atrial fibrillation : Subanalysis from J-RHYTHM study. (2010)
  • Author(s): Endo A, Kohsaka S, Suzuki S, Atarashi H, Kamakura S, Sakurai M, Nakaya H, Fukatani M, Mitamura H, Yamazaki T, Yamashita T, Ogawa S.
  • Journal Title: Circ J. 74(5) Epub 2010 Apr 3. Pages: 870-875
  • Peer Reviewed
• [Journal Article] J-RHYTHM Investigators. Efficacy and Safety of Antiarrhythmics Used in Patients with Paroxysmal Atrial Fibrillation : sub-analysis of J-RHYTHM study. (2010)
  • Author(s): Aizawa Y, Kohsaka S, Suzuki S, Atarashi H, Kamakura S, Sakurai M, Nakaya M, Fukatani M, Mitamura H, Yamazaki T, Yamashita T, Ogawa S.
  • Journal Title: Circ J. 74(1) Epub2009 Dec 2. Pages: 71-76
  • Peer Reviewed
• [Journal Article] J-RHYTHM Investigators. Efficacy and Safety of Antiarrhythmics Used in Patients with Paroxysmal Atrial Fibrillation : Sub-analysis of J-RHYTHM study. (2010)
  • Author(s): Aizawa Y, Kohsaka S, Suzuki S, Atazashi H, Kamakura S, Sakurai M, Nakaya M, Fukatani M, Mitamura, H, Yamazaki T, Yamashita T, Ogawa S
  • Journal Title: Circ J Volume: 74 Pages: 71-76
  • Peer Reviewed
• [Journal Article] J-RHYTHM Investigators. Impact of drug alteration to maintain rhythm control in paroxysmal atrial fibrillation : Subanalysis from J-RHYTHM study. (2010)
  • Author(s): Endo A, Kohsaka S, Suzuki S, Atarashi H, Kamakura S, Sakurai M, Nakaya H, Fukatani M, Mitamura H, Yamazaki T, Yamashita T, Ogawa S
  • Journal Title: Circ J. Volume: 74 Pages: 870-875
  • Peer Reviewed
• [Journal Article] Elevated troponin T on discharge predicts poor outcome of decompensated heart failure. (2010)
  • Author(s): Koide K, Yoshikawa T, Nagatomo Y, Kohsaka S, Anzai T, Meguro T, Ogawa S
  • Journal Title: Heart Vessels Volume: 25 Pages: 217-222
  • Peer Reviewed
• [Journal Article] Difference in Patient Profiles and Outcomes in Japanese Versus American Patients Undergoing Coronary Revascularization : A Collaborative Study by CREDO-Kyoto and the Texas Heart Institute Research Database. (2010)
  • Author(s): Kohsaka S, Kimura T, Goto M, Lee VV, Elayda MA, Furukawa Y, Fukushima M, Komeda M, Sakata R, Willerson, JT, Wilson, JM, Kita T
  • Journal Title: Am J Cardiol Volume: 105 Pages: 1698-1704
  • Peer Reviewed
• [Journal Article] Relationship between Serum Lipid Values and Atherosclerotic Burden in the Proximal Thoracic Aorta. (2010)
  • Author(s): Kohsaka S, Sacco RL, Jin Z, Liu R, Rundek T, Boden-Albala B, Homma S, Di Tullio MR
  • Journal Title: Int J Stroke Volume: 5 Pages: 257-263
  • Peer Reviewed
• [Journal Article] D-dimer levels in combination with clinical risk factors can effectively predict subsequent thromboembolic events in patients with atrial fibrillation during oral anticoagulant therapy. (2010)
  • Author(s): Sadanaga T, Kohsaka S, Ogawa S
  • Journal Title: Cardiology Volume: 117 Pages: 31-36
  • Peer Reviewed
• [Journal Article] Elevated B-type natriuretic peptide level as a marker of subsequent thromboembolic events in patients with atrial fibrillation. (2010)
  • Author(s): Sadanaga T, Kohsaka S, Mitamura H, Ogawa S
  • Journal Title: Heart Vessels. Volume: (Epub ahead of print)
  • Peer Reviewed
• [Journal Article] Difference in Patient Profiles and Outcomes in Japanese Versus American Patients Undergoing Coronary Revascularization : A Collaborative Study by CREDO-Kyoto and the Texas Heart Institute Research Database. (2010)
  • Author(s): Kohsaka S, Kimura T, Goto M, Lee W, Elayda MA, Furukawa Y, Fukushima M, Komeda M, Sakata R, Willerson, JT, Wilson, JM, Kita T.
  • Journal Title: Am J Cardiology (In Press)
  • Peer Reviewed
• [Presentation] Who will not Receive Optimized Medical Therapy after Percutaneous Coronary Intervention? Analysis from Japanese Prospective Multicenter Registry. (2011)
  • Author(s): Endo A, Kohsaka S, Miyata H, Kawamura A, Noma S, Suzuki M, Koyoma T, Ishikawa S, Momiyama Y, Nakagawa S, Sueyoshi K, Takagi S, Takahashi T, Takamoto S, Ogawa S, Fukuda K.
  • Organizer: The 75th Annual Scientific Meeting of the Japanese Circulation Society.
  • Place of Presentation: Yokohama, Japan.
  • Year and Date: 2011-03-20
• [Presentation] Percutaneous Coronary Intervention for Acute Coronary Syndrome; Comparison between Weekend Versus Weekday Presentation. (2011)
  • Author(s): Mogi S, Kohsaka S, Fukuda k, Miyata H, Noma S, Suzuki M, Koyoma T, Ishikawa S, Sueyoshi K, Takagi S, Takahashi T, Takamoto S, Ogawa S.
  • Organizer: The 75th Annual Scientific Meeting of the Japanese Circulation Society.
  • Place of Presentation: Yokohama, Japan.
  • Year and Date: 2011-03-20
• [Presentation] Bleeding Complication in Patients Undergoing PCI ; a Report from Multicenter Prospective Registry. (2011)
  • Author(s): Takahashi M, Kohsaka S, Miyata H, Kawamura A, Noma S, Suzuki M, Koyoma T, Ishikawa S, Hiyama Y, Nakagawa S, Sueyoshi K, Takagi S, Takahashi T, Takamoto S, Numasawa Y, Endo A, Mogi S, Ogawa S, Fukuda K.
  • Organizer: The 75th Annual Scientific Meeting of the Japanese Circulation Society.
  • Place of Presentation: Yokohama, Japan.
  • Year and Date: 2011-03-19
• [Presentation] The Relevance of Killip Classification in Patients with Acute Heart Failure Syndrome. (2011)
  • Author(s): Miyamoto T, Sakai T, Takagi A, Harada k, Kohsaka S, Iida K, Satoh N, Nagao K, Takayama M.
  • Organizer: The 75th Annual Scientific Meeting of the Japanese Circulation Society.
  • Place of Presentation: Yokohama, Japan.
  • Year and Date: 2011-03-19
• [Presentation] Perioperative Cardiac Risk of Noncardiac Surgery after Drug Eluting Stent Implantation. (2011)
  • Author(s): Ohno Y, Kawamura A, Mogi S, Takahashi M, Endo A, Numasawa Y, Arai T, Yuasa S, Kohsaka S, Furuta A, Maekawa Y, Kimura K, Sano M, Fukuda K.
  • Organizer: The 75th Annual Scientific Meeting of the Japanese Circulation Society.
  • Place of Presentation: Yokohama, Japan.
  • Year and Date: 2011-03-19
• [Presentation] Fukuda KClinical Predictors for Sustained Ventricular Tachyarrhythmia and Advanced AV Block in Patients with Cardiac Sarcoidosis. (2011)
  • Author(s): Nishiyama N, Satoh T, Nagai T, Kimura T, Fukumoto K, Aizawa Y, Kohsaka S, Karube Y, Miyoshi S, Takatsuki S, Ogawa S
  • Organizer: The 75th Annual Scientific Meeting of the Japanese Circulation Society.
  • Place of Presentation: Yokohama, Japan.
  • Year and Date: 2011-03-19
• [Presentation] Effect of Preprocedural Antiplatelets on Peak Cardiac Enzyme Values in PCI Patients with Acute Coronary Syndrome. (2011)
  • Author(s): Ikegami Y, Kohsaka S, Miyata H, Kawamura A, Noma S, Suzuki M, Koyama T, Ishikawa S, Momiyama Y, Nakagawa S, Sueyoshi K, Takagi S, Takahashi T, Takamoto S, Ogawa S, Fukuda k.
  • Organizer: The 75th Annual Scientific Meeting of the Japanese Circulation Society.
  • Place of Presentation: Yokohama, Japan.
  • Year and Date: 2011-03-19
• [Presentation] Long-term Predictors ofICD Shocks in patients with Brugada Syndrome. (2011)
  • Author(s): Aizawa Y, Sato T, Kohsaka S, Maeda A, Kimura T, Nishiyama N, Fukumoto K, Fukuda Y, Miyoshi S, Takatsuki S, Fukuda K.
  • Organizer: The 75th Annual Scientific Meeting of the Japanese Circulation Society.
  • Place of Presentation: Yokohama, Japan.
  • Year and Date: 2011-03-18
• [Presentation] Significance of Electrocardiographic Right Ventricular Hypertrophy in Patients with Pulmonary Hypertension with or without Right Ventricular Dysfunction. (2011)
  • Author(s): Nagai T, Kohsaka S, Murata M, Anzai T, Sato T, Fukuda k.
  • Organizer: The 75th Annual Scientific Meeting of the Japanese Circulation Society.
  • Place of Presentation: Yokohama, Japan.
  • Year and Date: 2011-03-18
• [Presentation] Outcomes of Percutaneous Coronary Intervention in Octogenarians with Acute Coronary Syndrome ; Crude Comparison of Drug Eluting vs. Bare Metal Stents. (2011)
  • Author(s): Maekawa Y, Kohsaka S, Miyata H, Ishikawa S, Koyoma T, Sueyoshi K, Suzuki M, Takagi S, Takahashi T, Nakagawa S, Noma S, Momiyama Y, Takamoto S, Kawamura A, Ogawa S, Fukuda K.
  • Organizer: The 75th Annual Scientific Meeting of the Japanese Circulation Society.
  • Place of Presentation: Yokohama, Japan.
  • Year and Date: 2011-03-18
• [Presentation] Elevaed B-type Natriuretic Peptide Level as a Maker of Subsequent Thromboembolic Events in Patienys, with Atrial Fibrillation. (2011)
  • Author(s): Sadanaga T, Kohsaka S, Mitamura H.
  • Organizer: The 75th Annual Scientific Meeting of the Japanese Circulation Society.
  • Place of Presentation: Yokohama, Japan.
  • Year and Date: 2011-03-18
• [Presentation] Left Atrial Reservoir Function in Patients with Atrial Fibrillation: Relation with Left Atrial Appendage Flow Velocity. (2011)
  • Author(s): Tsuruta H, Iwanaga S, Murata M, Yasuda R, Kohsaka S, Kimura T, Nishiyama N, Aizawa Y, Miyashi S, Takatsuki S, Fukuda K.
  • Organizer: The 75th Annual Scientific Meeting of the Japanese Circulation Society.
  • Place of Presentation: Yokohama, Japan.
  • Year and Date: 2011-03-18
• [Presentation] Safety of Transradial Approach for Percutaneous Coronary Intervention in the Japanese Multicenter Registry. (2011)
  • Author(s): Numasawa Y, Kohsaka S, Miyata H, Kawamura A, Noma S, Suzuki M, Koyama T, Ishikawa S, Momiyama Y, Nakagawa S, Sueyoshi K, Takagi S, Takahashi T, Takamoto S, Ogawa S, Fukuda K.
  • Organizer: The 75th Annual Scientific Meeting of the Japanese Circulation Society.
  • Place of Presentation: Yokohama, Japan.
  • Year and Date: 2011-03-18
• [Presentation] Long-term Predictors of ICD Shocks in patients with Brugada Syndrome. (2011)
  • Author(s): Aizawa Y, Sato T, Kohsaka S, Maeda A, Kimura T, Nishiyama N, Fukumoto K, Fukuda Y, Miyoshi S, Takatsuki S, Fukuda K.
  • Organizer: 第75回 日本循環器学会
  • Place of Presentation: パシフィコ横浜(横浜)
• [Presentation] Bleeding Complication in Patients Undergoing PCI ; a Report from Multicenter Prospective Registry. (2011)
  • Author(s): Takahashi M, Kohsaka S, Miyata H, Kawamura A, Noma S, Suzuki M, Koyoma T, Ishikawa S, Hiyama Y, Nakagawa S, Sueyoshi K, Takagi S, Takahashi T, Takamoto S, Numasawa Y, Endo A, Mogi S, Ogawa S, Fukuda K
  • Organizer: 第75回 日本循環器学会
  • Place of Presentation: パシフィコ横浜(横浜)
• [Presentation] Who will not Receive Optimized Medical Therapy after Percutaneous Coronary Intervention? Analysis from Japanese Prospective Multicenter Registry. (2011)
  • Author(s): Endo A, Kohsaka S, Miyata H, Kawamura A, Noma S, Suzuki M, Koyoma T, Ishikawa S, Momiyama Y, Nakagawa S, Sueyoshi K, Takagi S, Takahashi T, Takamoto S, Ogawa S, Fukuda K
  • Organizer: 第75回 日本循環器学会
  • Place of Presentation: パシフィコ横浜(横浜)
• [Presentation] Percutaneous Coronary Intervention for Acute Coronary Syndrome ; Comparison between Weekend Versus Weekday Presentation. (2011)
  • Author(s): Mogi S, Kohsaka S, Fukuda K, Miyata H, Noma S, Suzuki M, Koyoma T, Ishikawa S, Sueyoshi K, Takagi S, Takahashi T, Takamoto S, Ogawa S
  • Organizer: 第75回 日本循環器学会
  • Place of Presentation: パシフィコ横浜(横浜)
• [Presentation] Significance of Electrocardiographic Right Ventricular Hypertrophy in Patients with Pulmonary Hypertension with or without Right Ventricular Dysfunction. (2011)
  • Author(s): Nagai T, Kohsaka S, Murata M, Anzai T, Sato T, Fukuda K
  • Organizer: 第75回 日本循環器学会
  • Place of Presentation: パシフィコ横浜(横浜)
• [Presentation] Outcomes of Percutaneous Coronary Intervention in Octogenarians with Acute Coronary Syndrome ; Crude Comparison of Drug Eluting vs.Bare Metal Stents. (2011)
  • Author(s): Maekawa Y, Kohsaka S, Miyata H, Ishikawa S, Koyoma T, Sueyoshi K, Suzuki M, Takagi S, Takahashi T, Nakagawa S, Noma S, Momiyama Y, Takamoto S, Kawamura A, Ogawa S, Fukuda K
  • Organizer: 第75回 日本循環器学会
  • Place of Presentation: パシフィコ横浜(横浜)
• [Presentation] The Relevance of Killip Classification in Patients with Acute Heart Failure Syndrome. (2011)
  • Author(s): Miyamoto T, Sakai T, Takagi A, Harada K, Kohsaka S, Iida K, Satoh N, Nagao K, Takayama M
  • Organizer: 第75回日本循環器学会
  • Place of Presentation: パシフィコ横浜(横浜)
• [Presentation] Elevated B-type Natriuretic Peptide Level as Maker of Subsequent Thromboembolic Events in Patienys, with Atrial Fibrillation. (2011)
  • Author(s): Sadanaga T, Kohsaka S, Mitamura H
  • Organizer: 第75回 日本循環器学会
  • Place of Presentation: パシフィコ横浜(横浜)
• [Presentation] Left Atrial Reservoir Function in Patients with Atrial Fibrillation : Relation with Left Atrial Appendage Flow Velocity. (2011)
  • Author(s): Tsuruta H, Iwanaga S, Murata M, Yasuda R, Kohsaka S, Kimura T, Nishiyama N, Aizawa Y, Miyashi S, Takatsuki S, Fukuda K
  • Organizer: 第75回 日本循環器学会
  • Place of Presentation: パシフィコ横浜(横浜)
• [Presentation] Perioperative Cardiac Risk of Noncardiac Surgery after Drug Eluting Stent Implantation. (2011)
  • Author(s): Ohno Y, Kawamura A, Mogi S, Takahashi M, Endo A, Numasawa Y, Arai T, Yuasa S, Kohsaka S, Furuta A, Maekawa Y, Kimura K, Sano M, Fukuda K
  • Organizer: 第75回 日本循環器学会
  • Place of Presentation: パシフィコ横浜(横浜)
• [Presentation] Safety of Transradial Approach for Percutaneous Coronary Intervention in the Japanese Multicenter Registry. (2011)
  • Author(s): Numasawa Y, Kohsaka S, Miyata H, Kawamura A, Noma S, Suzuki M, Koyama T, Ishikawa S, Momiyama Y, Nakagawa S, Sueyoshi K, Takagi S, Takahashi T, Takamoto S, Ogawa S, Fukuda K
  • Organizer: 第75回 日本循環器学会
  • Place of Presentation: パシフィコ横浜(横浜)
• [Presentation] Clinical Predictors for Sustained Ventricular Tachyarrhythmia and Advanced AV Block in Patients with Cardiac Sarcoidosis. (2011)
  • Author(s): Nishiyama N, Satoh T, Nagai T, Kimura T, Fukumoto K, Aizawa Y, Kohsaka S, Karube Y, Miyoshi S, Takatsuki S, Ogawa S, Fukuda K
  • Organizer: 第75回日本循環器学会
  • Place of Presentation: パシフィコ横浜(横浜)
• [Presentation] Effect of Preprocedural Antiplatelets on Peak Cardiac Enzyme Values in PCI Patients with Acute Coronary Syndrome. (2011)
  • Author(s): Ikegami Y, Kohsaka S, Miyata H, Kawamura A, Noma S, Suzuki M, Koyama T, Ishikawa S, Momiyama Y, Nakagawa S, Sueyoshi K, Takagi S, Takahashi T, Takamoto S, Ogawa S, Fukuda K
  • Organizer: 第75回 日本循環器学会
  • Place of Presentation: パシフィコ横浜(横浜)
• [Presentation] Impact of serum biomarkers by the presence or absence of kidney disease in predicting long-term outcome among advanced systolic heart failure patients. (2010)
  • Author(s): Kohsaka S.
  • Organizer: XX World Congress ISHR
  • Place of Presentation: Kyoto Japan
  • Year and Date: 2010-05-14
• [Presentation] Patient Profiles in Japanese Versus American Patients Undergoing Coronary Revascularization : A Collaborative Study by CREDO-Kyoto and the Texas Heart Institute. (2010)
  • Author(s): 香坂俊
  • Organizer: 第74回日本循環器学会総会・学術集会
  • Place of Presentation: 京都
  • Year and Date: 2010-03-05
• [Presentation] Long-Term Outcomes in Japanese Versus American Patients Undergoing Coronary Revascularization : A Collaborative Study by CREDO-Kyoto and the Texas Heart Institute (2010)
  • Author(s): 香坂俊
  • Organizer: 第74回日本循環器学会総会・学術集会
  • Place of Presentation: 京都
  • Year and Date: 2010-03-05
• [Presentation] Impact of serum biomarkers by the presence or absence of kidney disease in predicting long-term outcome among advanced systolic heart failure patients. (2010)
  • Author(s): Kohsaka S
  • Organizer: 第27回国際心臓研究学会(ISHR)日本部会
  • Place of Presentation: 国立京都国際会館(京都)