| Project/Area Number |
21790754
|
|---|
| Research Category |
Grant-in-Aid for Young Scientists (B)
|
| Allocation Type | Single-year Grants |
|---|
| Research Field |
Circulatory organs internal medicine
|
|---|
| Research Institution | Tokyo Women's Medical University |
|---|
Principal Investigator |
MATSUURA Katsuhisa Tokyo Women's Medical University, 医学部, 講師 (70433993)
|
|---|
| Project Period (FY) |
2009 – 2010
|
| Project Status |
Completed (Fiscal Year 2010)
|
| Budget Amount *help |
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2010: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2009: ¥3,120,000 (Direct Cost: ¥2,400,000、Indirect Cost: ¥720,000)
|
|---|
| Keywords | 細胞シート / 心筋前駆細胞 / パラクライン効果 / 細胞シート移植 / パラクリン効果 / VCAM-1 / インテグリン |
|---|
| Research Abstract |
When cardiac Sca-1 positive cells were isolated from the adult murine heart and were transplanted to infarcted heart as cell sheet, significant improvement of cardiac function was observed. Soluble form of VCAM-1 secreted from Sca-1 positive cells enhanced angiogenesis, cardioprotection, and migration of Sca-1 positive cells, which contributed to the improvement of cardiac function after cell sheet transplantation.
|
