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The effect of 5-aminoimidazole-4-carboxamide ribonucleoside (AMPK)on malignant mesothelioma cell growth and survival interval in an implant animal model of malignant mesothelioma

Research Project

Project/Area Number 21790763
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeSingle-year Grants
Research Field Respiratory organ internal medicine
Research InstitutionTohoku University

Principal Investigator

NIU Kaijun  東北大学, 大学院・医工学研究科, 准教授 (70447134)

Project Period (FY) 2009 – 2011
Project Status Completed (Fiscal Year 2011)
Budget Amount *help
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2011: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2010: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2009: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
Keywords非閉塞性肺疾患癌 / 肺線維症 / 呼吸器感染症 / ヒト悪性中皮腫 / 悪性中皮腫 / AMPK活性 / AICAR / SCIDマウス / 細胞周期 / アポトーシス / AMPK活性化
Research Abstract

In vitro, AICAR treatment significantly impaired the cell proliferation rate of malignant mesothelioma (MM)cell lines. In vivo, treatment with AICAR significantly decreased the growth rate of MM, which was accompanied by an increase in p53/phosphor-p53 levels, and down-regulated protein levels of phosphor-Akt and p70/phosphor-p70. Similar intracellular pathways are also observed in vitro experiment. These effects partly involved induction of growth arrest and apoptosis to MM cells. AICAR treatment activated AMPK. Finally, AICAR treatment also significantly extended survival interval in an implant animal model of MM. These findings suggested that AICAR or the induction of AMPK activity is an important tactic for developing therapeutic strategies against MM.

Report

(4 results)
  • 2011 Annual Research Report   Final Research Report ( PDF )
  • 2010 Annual Research Report
  • 2009 Annual Research Report
  • Research Products

    (6 results)

All 2012 2011 2010 Other

All Journal Article (2 results) (of which Peer Reviewed: 2 results) Presentation (1 results) Remarks (3 results)

  • [Journal Article] Adiponectin Pathway Attenuates Malignant Mesothelioma Cell Growth2012

    • Author(s)
      Niu K, Asada M, et al
    • Journal Title

      Am J Respir Cell Mol Biol

      Volume: 46 Issue: 4 Pages: 515-523

    • DOI

      10.1165/rcmb.2011-0068oc

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Adiponectin pathway attenuates malignant mesothelioma cell growth2011

    • Author(s)
      Kaijun Niu, Masanori Asada, Tatsuma Okazaki, Shinsuke Yamanda, Takae Ebihara, Hui Guo, Dongying Zhang, Ryoichi Nagatomi, Hiroyuki Arai, Masahiro Kohzuki, and Satoru Ebihara
    • Journal Title

      Am J Respir Cell Mol Biol

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Presentation] AMP活性化プロテインキナーゼ活性化と悪性中皮腫2010

    • Author(s)
      牛凱軍、海老原覚、浅田成紀、矢満田慎介、岡崎達馬、荒井啓行、永富良一
    • Organizer
      第50回日本呼吸器学会学術講演会
    • Place of Presentation
      京都・国立京都国際会館
    • Year and Date
      2010-04-24
    • Related Report
      2011 Final Research Report 2010 Annual Research Report
  • [Remarks]

    • URL

      http://db.tohoku.ac.jp/whois/detail/335591bd83c5e95f47e756e87c06e8c9.html

    • Related Report
      2011 Annual Research Report
  • [Remarks]

    • URL

      http://db.tohoku.ac.jp/Whois/detail/335591bd83c5e95f47e756e87c06e8c9.html

    • Related Report
      2010 Annual Research Report
  • [Remarks]

    • URL

      http://db.tohoku.ac.jp/whois/detail/335591bd83c5e95f47e756e87c06e8c9.html

    • Related Report
      2009 Annual Research Report

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Published: 2009-04-01   Modified: 2016-04-21  

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