The role of CCN family signaling in pulmonary fibrosis, and CCN pathway may be an effective molecular therapeutic strategy for fibrotic lung disease
| Project/Area Number |
21790772
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Respiratory organ internal medicine
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| Research Institution | The University of Tokushima |
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Principal Investigator |
AZUMA Momoyo The University of Tokushima, 病院, 特任助教 (10403750)
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| Project Period (FY) |
2009 – 2010
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| Project Status |
Completed (Fiscal Year 2010)
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| Budget Amount *help |
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2010: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2009: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
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| Keywords | 肺線維症 / CCNインテグリン / FAK / CCN6 / β1インテグリン / CCNファミリー / インテグリン |
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| Research Abstract |
Idiopathic pulmonary fibrosis is a progressive and lethal disease of the lung. Here, we demonstrated that CCN6 induced the proliferation of lung fibroblasts by binding to integrin……Furthermore, CCN6 showed ability to stimulate the expression of fibronectin. Our results suggest that CCN6 is a potential target for the treatment of pulmonary fibrosis.
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Report
(3 results)
Research Products
(11 results)
