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Establishment of assay system of renal generaration and development of livestock animal model for parmanent production of donor kidney

Research Project

Project/Area Number 21790794
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeSingle-year Grants
Research Field Kidney internal medicine
Research InstitutionUniversity of Tsukuba

Principal Investigator

USUI Joichi  筑波大学, 医学医療系, 講師 (70447340)

Project Period (FY) 2009 – 2012
Project Status Completed (Fiscal Year 2012)
Budget Amount *help
¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2012: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2011: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2010: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2009: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Keywords腎臓学 / 再生医学 / 幹細胞 / 腎移植 / 腎臓発生 / 糸球体腎炎
Research Abstract

I have progressed to develop how to produce donor kidneys using kidney stem cells and kidney developmental mechanism. I made studies of the production of donor kidney with iPS/ES cells, the establishment of in vitro assay for kidney differentiation, expansion to human kidney diseases and livestock animal experiment.

Report

(5 results)
  • 2012 Annual Research Report   Final Research Report ( PDF )
  • 2011 Annual Research Report
  • 2010 Annual Research Report
  • 2009 Annual Research Report
  • Research Products

    (21 results)

All 2013 2012 2011 2010 2009 2008 Other

All Journal Article (11 results) (of which Peer Reviewed: 4 results) Presentation (5 results) Remarks (4 results) Patent(Industrial Property Rights) (1 results) (of which Overseas: 1 results)

  • [Journal Article] Generation of kidney from pluripotent stem cells via blastocyst complementation.2012

    • Author(s)
      Usui J, et al.
    • Journal Title

      Am J Pathol

      Volume: 180 Issue: 6 Pages: 2417-2426

    • DOI

      10.1016/j.ajpath.2012.03.007

    • Related Report
      2012 Annual Research Report 2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] 腎疾患アプローチのための解剖生理2012

    • Author(s)
      臼井丈一、山縣邦弘
    • Journal Title

      薬局

      Volume: Vol.63 Pages: 972-975

    • Related Report
      2012 Final Research Report
  • [Journal Article] 腎疾患アプローチのための解剖生理2012

    • Author(s)
      臼井丈一
    • Journal Title

      薬局

      Volume: 63 Pages: 972-975

    • Related Report
      2012 Annual Research Report 2011 Annual Research Report
  • [Journal Article] Generation of kidney from pluripotent stem cells via blastocyst complementation2012

    • Author(s)
      Usui J, et al.
    • Journal Title

      Am J Pathol

      Volume: (In press)

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 研究の窓辺2011

    • Author(s)
      臼井丈一
    • Journal Title

      血圧

      Volume: Vol.18 Pages: 1272-1273

    • Related Report
      2012 Final Research Report 2011 Annual Research Report
  • [Journal Article] 腎疾患アプローチのための解剖生理2011

    • Author(s)
      臼井丈一、山縣邦弘
    • Journal Title

      薬局

      Volume: Vol.62 Pages: 538-541

    • Related Report
      2012 Final Research Report
  • [Journal Article] 腎疾患アプローチのための解剖生理2011

    • Author(s)
      臼井丈一, 他
    • Journal Title

      薬局

      Volume: 62 Pages: 538-541

    • Related Report
      2010 Annual Research Report
  • [Journal Article] Generation of rat pancreas in mouse by interspecific blastocyst injection of pluripotent stem cells.2010

    • Author(s)
      Kobayashi T,...Usui J et al.
    • Journal Title

      Cell

      Volume: 142 Pages: 787-799

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] 腎疾患アプローチのための解剖生理2010

    • Author(s)
      臼井丈一、山縣邦弘
    • Journal Title

      薬局

      Volume: Vol.61 Pages: 500-503

    • Related Report
      2012 Final Research Report
  • [Journal Article] Generation of rat pancreas in mouse by interspecific blastocyst injection of pluripotent stem cells2010

    • Author(s)
      Kobayashi T, et al.
    • Journal Title

      Cell

      Volume: 142 Pages: 787-799

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 腎疾患アプローチのための解剖生理2010

    • Author(s)
      臼井丈一, 他
    • Journal Title

      薬局 61

      Pages: 500-503

    • Related Report
      2009 Annual Research Report
  • [Presentation] 遺伝子改変マウスを用いた腎臓再構築の試み2013

    • Author(s)
      西中村隆一、...臼井丈一
    • Organizer
      第12回日本再生医療学会総会
    • Place of Presentation
      パシフィコ横浜、横浜市
    • Year and Date
      2013-03-22
    • Related Report
      2012 Final Research Report
  • [Presentation] 腎臓欠損マウスに作成したiPS細胞キメラ腎臓(腎臓再生モデル)における脈管形成の解析2012

    • Author(s)
      臼井丈一
    • Organizer
      第55回日本腎臓学会学術総会
    • Place of Presentation
      パシフィコ横浜、横浜市
    • Year and Date
      2012-06-01
    • Related Report
      2012 Final Research Report
  • [Presentation] 腎臓欠損モデルマウスとblastocyst complementation を組み合わせたマウスES/iPS細胞由来腎臓の作成2009

    • Author(s)
      臼井丈一
    • Organizer
      第15回分子腎臓研究会
    • Place of Presentation
      京都市
    • Year and Date
      2009-09-05
    • Related Report
      2012 Final Research Report
  • [Presentation] 腎臓欠損モデルマウスと blastocyst complementation を組み合わせたマウスES/iPS細胞由来腎臓の作成2009

    • Author(s)
      臼井丈一, 他
    • Organizer
      第15回分子腎臓研究会
    • Place of Presentation
      京都
    • Year and Date
      2009-09-05
    • Related Report
      2009 Annual Research Report
  • [Presentation] 腎臓欠損マウスに作成したiPS細胞キメラ腎臓(腎臓再生モデル)における脈管形成の解析

    • Author(s)
      臼井丈一
    • Organizer
      第55回日本腎臓学会学術総会
    • Place of Presentation
      パシフィコ横浜(神奈川県)
    • Related Report
      2012 Annual Research Report
  • [Remarks] ホームページ等筑波大学腎臓内科学研究紹介HP

    • URL

      http://www.tsukuba-igaku-kidney.com/up/index.php?mode=s&cate=3&seq=40

    • Related Report
      2012 Final Research Report
  • [Remarks] 筑波大学臨床医学系腎臓内科研究一覧

    • URL

      http://www.tsukuba-igaku-kidney.com/up/index.php?mode=s&cate=3&seq=40

    • Related Report
      2012 Annual Research Report
  • [Remarks]

    • URL

      http://www.tsukuba-igaku-kidney.com/up/index.php?mode=s&cate=3&seq=40

    • Related Report
      2011 Annual Research Report
  • [Remarks]

    • URL

      http://www.tsukuba-igaku-kidney.com/up/index.php?mode=s&cate=3&seq=40

    • Related Report
      2010 Annual Research Report
  • [Patent(Industrial Property Rights)] BLASTOCYST COMPLEMENTATIONを利用した臓器再生法2008

    • Inventor(s)
      中内啓光,小林俊寛,李允秀,臼井丈一
    • Industrial Property Rights Holder
      国立大学法人東京大学
    • Filing Date
      2008-08-28
    • Related Report
      2012 Final Research Report
    • Overseas

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Published: 2009-04-01   Modified: 2019-07-29  

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