Mechanism of IgA deposition in mesangial cells in IgA nephropathy and application for therapy
| Project/Area Number |
21790800
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Kidney internal medicine
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| Research Institution | Niigata University |
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Principal Investigator |
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| Project Period (FY) |
2009 – 2011
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| Project Status |
Completed (Fiscal Year 2011)
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| Budget Amount *help |
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2011: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
Fiscal Year 2010: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2009: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
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| Keywords | 腎臓学 / IgA腎症 / メサンギウム細胞 / 糖鎖不全 / インテグリン |
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| Research Abstract |
Immunoglobulin A nephropathy(IgAN) is the most common form of primary glomerulonephritis and is characterized by glomerular mesangial IgA1 deposition, however, precise mechanism of IgA1 deposition are still unclear. The aim of the present study is to identify the receptor for IgA1 in mesangial cells using IgA1 probe, and integrinα1/β1 andα2/β1 heterodimer was identified as the receptors for IgA1.
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Report
(4 results)
Research Products
(11 results)
