| Budget Amount *help |
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2010: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2009: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
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| Research Abstract |
We hypothesized that TLR4 might be involved in the development of UO induced renal injury, which has been reported that it plays a role in the pathogenesis of liver fibrosis. The current study was performed using wild type, deficient, (TLR4 knock out mice) and HEJ(TLR4 defective) mice which were inducted UUO. We compared these groups using parameters such as microcirculation, histological and molecular biological methods The results suggested that TLR4 would be related with the early phase of renal fibrosis induced by UO.
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