| Budget Amount *help |
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2010: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2009: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
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| Research Abstract |
The aim of the present study is to evaluate the oxidative stress and its relationship with kidney and cardiovascular disease in chronic kidney disease (CKD). In 2009, we performed the experiments using adriamysin CKD model rats and 5/6 nephrectomized CKD model rats. Furthermore, in 2010, we performed the experiment using type 2 diabetes model rats. In these experiments, we demonstrated the detailed mechanisms of the progression of kidney and cardiovascular lesions in CKD and the importance of suppression of oxidative stress for the progression.
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