Functional analysis of ERK signaling pathway in ERK1/2 kidney specific knockout mice
Project/Area Number |
21790818
|
Research Category |
Grant-in-Aid for Young Scientists (B)
|
Allocation Type | Single-year Grants |
Research Field |
Kidney internal medicine
|
Research Institution | Kyoto Prefectural University of Medicine |
Principal Investigator |
SUGIYAMA Noriyuki Kyoto Prefectural University of Medicine, 医学研究科, 助教 (90381954)
|
Project Period (FY) |
2009 – 2010
|
Project Status |
Completed (Fiscal Year 2010)
|
Budget Amount *help |
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2010: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2009: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
|
Keywords | 腎臓学 / 嚢胞腎 / Erk / ノックアウトマウス / 急性腎不全 / 細胞内シグナル伝達系 / 細胞増殖 |
Research Abstract |
This study is that analysis of Erk in kidney. We obtained that Erk functioned renal regeneration after ischemia-refusion. The next study indicates that random oriented cell division is an initial event for renal tubule expansion and precedes cell proliferation in inv mutant kidneys. However, our results do not support the hypothesis that the canonical Wnt signaling pathway is involved in renal cyst development of inv mutant mice.
|
Report
(3 results)
Research Products
(21 results)
-
-
-
-
-
[Journal Article] Abnormal Epithelial Cell Polarity and Ectopic Epidermal Growth Factor Receptor (EGFR) Expression Induced in Emx2 KO Embryonic Gonads.2010
Author(s)
Kusaka M, Katoh-Fukui Y, Ogawa H, Miyabayashi K, Baba T, Shima Y, Sugiyama N, Sugimoto Y, Okuno Y, Kodama R, Iizuka-Kogo A, Senda T, Sasaoka T, Kitamura K, Aizawa S, Morohashi KI.
-
Journal Title
Endocrinology. 151(12)
Pages: 5893-5904
NAID
Related Report
Peer Reviewed
-
-
-
-
[Presentation] 嚢胞腎疾患と一次線毛2010
Author(s)
杉山紀之
Organizer
第13回埼玉若手腎臓病若手研究会 招待講演
Place of Presentation
大宮 パレスホテル大宮
Year and Date
2010-12-11
Related Report
-
-
[Presentation] 繊毛と嚢胞腎2010
Author(s)
杉山紀之
Organizer
第32回腎臓セミナー 招待講演
Place of Presentation
東京 海運ビル
Year and Date
2010-08-28
Related Report
-
[Presentation] 繊毛と嚢胞腎2010
Author(s)
杉山紀之
Organizer
第32回腎臓セミナー
Place of Presentation
海運ホテル(東京)
Year and Date
2010-08-28
Related Report
-
-
-
-
-
-
-
-
-