Contribution of (pro)renin receptor to the development of insulin resistance in obese hypertension

Research Project

Project/Area Number	21790820
Research Category	Grant-in-Aid for Young Scientists (B)
Allocation Type	Single-year Grants
Research Field	Kidney internal medicine
Research Institution	Keio University
Principal Investigator	KAMAYACHI Tadashi Keio University, 医学部, 助教 (40365234)
Project Period (FY)	2009 – 2010
Project Status	Completed (Fiscal Year 2010)
Budget Amount *help	¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000) Fiscal Year 2010: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000) Fiscal Year 2009: ¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000)
Keywords	(プロ)レニン受容体 / メタボリックシンドローム / インスリン抵抗性
Research Abstract	We studied the influence of insulin resistance when we administered obese and lean hypertensive rats (pro) renin receptor blocker, the decoy and its scramble for 12 weeks. Intraperitoneal glucose tolerance test results in obese was higher than lean in the glucose level in the untreated group. The scramble treatment group had no change in blood glucose, but the decoy treatment group was improved. The intraperitoneal insulin tolerance test compared before and after administration of insulin to glucose levels after administration of insulin in 90 minutes and in 120 minutes. The scramble treatment did not improve lowering blood glucose levels, but the decoy treatment improved. The obese decoy treatment group had increased the skeletal muscle Ark phosphorylation more than the obese untreated group.