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Contribution of (pro)renin receptor to the development of insulin resistance in obese hypertension

Research Project

Project/Area Number 21790820
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeSingle-year Grants
Research Field Kidney internal medicine
Research InstitutionKeio University

Principal Investigator

KAMAYACHI Tadashi  Keio University, 医学部, 助教 (40365234)

Project Period (FY) 2009 – 2010
Project Status Completed (Fiscal Year 2010)
Budget Amount *help
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2010: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2009: ¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000)
Keywords(プロ)レニン受容体 / メタボリックシンドローム / インスリン抵抗性
Research Abstract

We studied the influence of insulin resistance when we administered obese and lean hypertensive rats (pro) renin receptor blocker, the decoy and its scramble for 12 weeks. Intraperitoneal glucose tolerance test results in obese was higher than lean in the glucose level in the untreated group. The scramble treatment group had no change in blood glucose, but the decoy treatment group was improved. The intraperitoneal insulin tolerance test compared before and after administration of insulin to glucose levels after administration of insulin in 90 minutes and in 120 minutes. The scramble treatment did not improve lowering blood glucose levels, but the decoy treatment improved. The obese decoy treatment group had increased the skeletal muscle Ark phosphorylation more than the obese untreated group.

Report

(3 results)
  • 2010 Annual Research Report   Final Research Report ( PDF )
  • 2009 Annual Research Report
  • Research Products

    (3 results)

All 2010 Other

All Presentation (2 results) Remarks (1 results)

  • [Presentation] Contribution of (pro) renin receptor to the development of insulin resistance in obese hypertensive rats2010

    • Author(s)
      釜萢正
    • Organizer
      第14回国際内分泌学会議
    • Place of Presentation
      日本京都
    • Year and Date
      2010-03-28
    • Related Report
      2010 Final Research Report
  • [Presentation] Contribution of (pro)renin receptor to the development of insulin resistance in obese hypertensive rats2010

    • Author(s)
      釜萢正
    • Organizer
      第14回国際内分泌学会議
    • Place of Presentation
      日本京都
    • Year and Date
      2010-03-28
    • Related Report
      2009 Annual Research Report
  • [Remarks] ホームページ等 なし

    • Related Report
      2010 Final Research Report

URL: 

Published: 2009-04-01   Modified: 2016-04-21  

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