The analysis of the role of autophagy related proteins in glomerular epitherial cell
Project/Area Number |
21790821
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Research Category |
Grant-in-Aid for Young Scientists (B)
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Allocation Type | Single-year Grants |
Research Field |
Kidney internal medicine
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Research Institution | Juntendo University |
Principal Investigator |
ASANUMA Etsuko Juntendo University, 医学部, 非常勤助教 (30508172)
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Project Period (FY) |
2009 – 2010
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Project Status |
Completed (Fiscal Year 2010)
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Budget Amount *help |
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2010: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2009: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
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Keywords | 糸球体上皮細胞 / 糸球体硬化 / ネフローゼ症候群 / オートファジー / GABARAP / P62 / 細胞内蛋白凝集 / Atg7 |
Research Abstract |
We analysed the role of autophagy related proteins, GABARAP and Atg7, in the glomerular epitherial cells (podocytes). The observation of GABARAP transgenic mice showed that GABARAP was responsible for an impairment of glomerular function. Atg7 was essential for processing of GABARAP, and we generated podocyte-specific Atg7 deficient mice. The observation of these mice revealed that Atg7 also related to the mechanism of podocyte injury.
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Report
(3 results)
Research Products
(6 results)
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[Journal Article] Dendrin location in podocytes is associated with the disease progression in animal and human glomarulopathy.2011
Author(s)
Katsuhiko Asanuma, Miyuki Akiba-Takagi, Fumiko Kodama, Rin Asao, Yoshiko Nagai, Aida Lydia, Hiromitsu Fukuda, Eriko Tanaka, Terumi Shibata, Hisatsugu Takahara, Teruo Hidaka, Etsuko Asanuma, Eiki Kominami, Takashi Ueno, Yasuhiko Tomino
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Journal Title
American Journal of Nephrology. accepted on March
Related Report
Peer Reviewed
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