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Searching for the immune target of acute inflammatory demyelinating polyneuropathy by using proteomic analysis.

Research Project

Project/Area Number 21790833
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeSingle-year Grants
Research Field Neurology
Research InstitutionChiba University

Principal Investigator

SAWAI Setsu  Chiba University, 大学院・医学研究院, 助教 (10400962)

Project Period (FY) 2009 – 2010
Project Status Completed (Fiscal Year 2010)
Budget Amount *help
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2010: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
Fiscal Year 2009: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Keywords神経病態免疫学 / ギラン / バレー症候群 / ギラン・バレー症候群 / プロテオーム / 質量分析計 / 自己抗体
Research Abstract

By using proteomic analysis, we searched for the immune target of Acute Inflammatory Demyelinating Polyneuropathy (AIDP). The target was considered to be the protein on the surface of the Schwann cell. We extract proteins from Schwannoma cell line, and we searched for the protein which reacted with the antibody (IgG) of the patients by 2 dimensional electrophoresis and western blotting. The proteins were identified with mass spectrometer. In the result, 3 proteins were thought to be the possible targets, and we found the autoantibodies against these proteins in the sera of the patients.

Report

(3 results)
  • 2010 Annual Research Report   Final Research Report ( PDF )
  • 2009 Annual Research Report
  • Research Products

    (35 results)

All 2011 2010 2009

All Journal Article (17 results) (of which Peer Reviewed: 15 results) Presentation (17 results) Patent(Industrial Property Rights) (1 results)

  • [Journal Article] Altered axonal excitability properties in juvenile muscular atrophy of distal upper extremity (Hirayama disease).2011

    • Author(s)
      Sawai S, Misawa S, Kanai K, Isose S, Shibuya K, Noto Y, Fujimaki Y, Sekiguchi Y, Nasu S, Nomura F, Kuwabara S.
    • Journal Title

      Clin Neurophysiol. 122(1)

      Pages: 205-209

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Elevated CSF TDP-43 levels in amyotrophic lateral sclerosis : Specificity, sensitivity, and a possible prognostic value.2011

    • Author(s)
      Noto Y, Shibuya K, Sato Y, Kanai K, Misawa S, Sawai S, Mori M, Uchiyama T, Isose S, Nasu S, Sekiguchi Y, Fujimaki Y, Kasai T, Tokuda T, Nakagawa M, Kuwabara S.
    • Journal Title

      Amyotroph Lateral Scler. 12(2)

      Pages: 140-143

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Elevated CSF TDP-43 levels in amyotrophic lateral sclerosis : specificity, sensitivity, and a possible prognostic value.2011

    • Author(s)
      Noto Y
    • Journal Title

      Amyotrophic Lateral Sclerosis

      Volume: 12 Pages: 140-143

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Serum levels of complement C4 fragments correlate with disease activity in multiple sclerosis : proteomic analysis.2010

    • Author(s)
      Sawai S, Umemura H, Mori M, Satoh M, Hayakawa S, Kodera Y, Tomonaga T, Kuwabara S, Nomura F.
    • Journal Title

      J Neuroimmunol. 25;218(1-2)

      Pages: 112-115

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Multifocal conduction blocks in sarcoid peripheral neuropathy.2010

    • Author(s)
      Sawai S, Misawa S, Kobayashi M, Kanai K, Isose S, Shibuya K, Sekiguchi Y, Nasu S, Noto Y, Fujimaki Y, Koga S, Ohtani R, Kuwabara S.
    • Journal Title

      Intern Med. 49(5)

      Pages: 471-474

    • NAID

      130000251698

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Spinal myoclonus in the periscapular muscles after mastectomy assessed by FDG-PET.2010

    • Author(s)
      Misawa S, Hayakawa S, Himuro K, Sawai S, Akaogi Y, Ito S, Kuwabara S.
    • Journal Title

      Clin Neurol Neurosurg. 112(6)

      Pages: 527-529

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Altered axonal excitability properties in juvenile muscular atrophy of distal upper extremity (Hirayama disease).2010

    • Author(s)
      Sawai S
    • Journal Title

      Clinical Neurophysiology

      Volume: 122 Pages: 205-209

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Spinal myoclonus in the periscapular muscles after mastectomy assessed by FDG-PET.2010

    • Author(s)
      Misawa S
    • Journal Title

      Clinical Neurology and Neurosurgery

      Volume: 112 Pages: 527-529

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Serum levels of complement C4 fragments correlate with disease activity in multiple sclerosis : proteomic analysis2010

    • Author(s)
      Sawai S
    • Journal Title

      Journal of Neuroimmunology 218

      Pages: 112-115

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Chronic inflammatory demyelinating polyneuropathy sera inhibit axonal growth of mouse dorsal root ganglion neurons by activation of Rho-kinase.2009

    • Author(s)
      Taniguchi J, Sawai S, Mori M, Kubo T, Kanai K, Misawa S, Isose S, Yamashita T, Kuwabara S.
    • Journal Title

      Ann Neurol. 66(5)

      Pages: 694-697

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Tokyo Metropolitan Neuromuscular Electrodiagnosis Study Group. Utility of the distal compound muscle action potential duration for diagnosis of demyelinating neuropathies.2009

    • Author(s)
      Isose S, Kuwabara S, Kokubun N, Sato Y, Mori M, Shibuya K, Sekiguchi Y, Nasu S, Fujimaki Y, Noto Y, Sawai S, Kanai K, Hirata K, Misawa S
    • Journal Title

      J Peripher Nerv Syst. 14(3)

      Pages: 151-158

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Physicochemical property changes of amino acid residues that accompany missense mutations in SCN1A affect epilepsy phenotype severity.2009

    • Author(s)
      Kanai K, Yoshida S, Hirose S, Oguni H, Kuwabara S, Sawai S, Hiraga A, Fukuma G, Iwasa H, Kojima T, Kaneko S.
    • Journal Title

      J Med Genet. 46(10)

      Pages: 671-679

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Chronic inflammatory demyelinating polyneuropathy sera inhibit axonal growth of mouse dorsal root ganglion neurons by activation of Rho-kinase2009

    • Author(s)
      Taniguchi J
    • Journal Title

      Annals of Neurology 66

      Pages: 694-697

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Utility of the distal compound muscle action potential duration for diagnosis of demyelinating neuropathies2009

    • Author(s)
      Isose S
    • Journal Title

      Journal of the Peripheral Nervous System 14

      Pages: 151-158

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Physicochemical property changes of amino acid residues that accompany missense mutations in SCN1A affect epilepsy phenotype severity2009

    • Author(s)
      Kauai K
    • Journal Title

      Journal of Medical Genetics 46

      Pages: 671-679

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] c-myc遺伝子転写抑制因子FIRの splicing variant を標的とした癌診断法・治療法の開発2009

    • Author(s)
      松下一之
    • Journal Title

      臨床病理 57

      Pages: 1151-1158

    • Related Report
      2009 Annual Research Report
  • [Journal Article] 未来を見据えた遺伝子検査-遺伝病-2009

    • Author(s)
      西村基
    • Journal Title

      Laboratory and Clinical Practice 27

      Pages: 52-57

    • Related Report
      2009 Annual Research Report
  • [Presentation] MALDI Bio Typer^<TM>を用いたプロテオミクスによる微生物迅速同定法の評価2010

    • Author(s)
      曽川一幸
    • Organizer
      日本臨床検査自動化学会42回大会
    • Place of Presentation
      神戸国際会議場
    • Year and Date
      2010-10-09
    • Related Report
      2010 Final Research Report
  • [Presentation] MALDI Bio TyperTMを用いたプロテオミクスによる微生物迅速同定法の評価2010

    • Author(s)
      曽川一幸
    • Organizer
      日本臨床検査自動化学会42回大会
    • Place of Presentation
      神戸
    • Year and Date
      2010-10-09
    • Related Report
      2010 Annual Research Report
  • [Presentation] C型慢性肝障害においては、線維化につれ血中中性脂肪プロファイルは変化する2010

    • Author(s)
      西村基
    • Organizer
      第57回日本臨床検査医学会学術集会
    • Place of Presentation
      京王プラザホテル
    • Year and Date
      2010-09-10
    • Related Report
      2010 Annual Research Report 2010 Final Research Report
  • [Presentation] 新規腫瘍マーカーとしてのc-myc遺伝子転写抑制因子FIRに対する血清中自己抗体検出の試み2010

    • Author(s)
      松下一之
    • Organizer
      第57回日本臨床検査医学会学術集会
    • Place of Presentation
      京王プラザホテル
    • Year and Date
      2010-09-10
    • Related Report
      2010 Annual Research Report 2010 Final Research Report
  • [Presentation] 遺伝性神経筋疾患の発症前診断における遺伝カウンセリング -千葉大病院における20例の検討-2010

    • Author(s)
      澤井摂
    • Organizer
      第17回日本遺伝子診療学会大会
    • Place of Presentation
      三重県医師会館
    • Year and Date
      2010-08-07
    • Related Report
      2010 Final Research Report
  • [Presentation] 千葉大学病院遺伝子診療部における脊髄小脳変性症の遺伝カウンセリング ~遺伝カウンセリング記録と遺伝学的検査結果の検討~2010

    • Author(s)
      宇津野恵美
    • Organizer
      第17回日本遺伝子診療学会大会
    • Place of Presentation
      三重県医師会館
    • Year and Date
      2010-08-07
    • Related Report
      2010 Final Research Report
  • [Presentation] 遺伝性神経筋疾患の発症前診断における遺伝カウンセリング-千葉大病院における20例の検討-2010

    • Author(s)
      澤井摂
    • Organizer
      第17回日本遺伝子診療学会大会
    • Place of Presentation
      三重県医師会館
    • Year and Date
      2010-08-07
    • Related Report
      2010 Annual Research Report
  • [Presentation] 千葉大学病院遺伝子診療部における脊髄小脳変性症の遺伝カウンセリング~遺伝カウンセリング記録と遺伝学的検査結果の検討~2010

    • Author(s)
      宇津野恵美
    • Organizer
      第17回日本遺伝子診療学会大会
    • Place of Presentation
      三重県医師会館
    • Year and Date
      2010-08-07
    • Related Report
      2010 Annual Research Report
  • [Presentation] Crow-Fukase症候群における血清free light chain測定の意義2010

    • Author(s)
      澤井摂
    • Organizer
      第51回日本神経学会総会
    • Place of Presentation
      東京国際フォーラム
    • Year and Date
      2010-05-22
    • Related Report
      2010 Annual Research Report 2010 Final Research Report
  • [Presentation] POEMS症候群患者血清におけるサイトカインプロファイル解析2010

    • Author(s)
      金井数明
    • Organizer
      第51回日本神経学会総会
    • Place of Presentation
      東京国際フォーラム
    • Year and Date
      2010-05-22
    • Related Report
      2010 Annual Research Report 2010 Final Research Report
  • [Presentation] 千葉大学病院における神経筋疾患の発症前診断に対する遺伝カウンセリング2010

    • Author(s)
      澤井摂
    • Organizer
      第34回日本遺伝カウンセリング学会学術集会
    • Place of Presentation
      東京女子医科大学、弥生記念講堂
    • Year and Date
      2010-04-29
    • Related Report
      2010 Final Research Report
  • [Presentation] 千葉大学病院における神経筋疾患の発症前診断に対する遺伝カウンセリング2010

    • Author(s)
      澤井摂
    • Organizer
      第34回日本遺伝カウンセリング学会学術集会
    • Place of Presentation
      東京女子医科大学 弥生記念講堂
    • Year and Date
      2010-04-29
    • Related Report
      2010 Annual Research Report
  • [Presentation] Measurement of serum 5.9 kDa fragment of fibrinogen α chain (FIB 5.9) by MALDI-TOF MS with stable-isotope labeled standard in patients with liver diseases.2010

    • Author(s)
      Nomura F
    • Organizer
      MSACL 2010
    • Place of Presentation
      San Diego, CA
    • Year and Date
      2010-02-08
    • Related Report
      2010 Final Research Report
  • [Presentation] Measurement of serum 5.9 kDa fragment of fibrinogen α chain(FIB 5.9)by MALDI-TOF MS with stable-isotope labeled standard in patients with liver diseases2010

    • Author(s)
      Nomura F
    • Organizer
      MSACL 2010
    • Place of Presentation
      San Diego, CA
    • Year and Date
      2010-02-08
    • Related Report
      2009 Annual Research Report
  • [Presentation] MALDI-TOF MSを用いたプロテオーム解析による多発性硬化症における疾患活動性マーカーの探索2009

    • Author(s)
      澤井摂
    • Organizer
      第41回日本臨床検査自動化学会大会
    • Place of Presentation
      パシフィコ横浜
    • Year and Date
      2009-10-10
    • Related Report
      2010 Final Research Report
  • [Presentation] MALDI-TOF MSを用いたプロテオーム解析による多発性硬化症における疾患活動性マーカーの探索2009

    • Author(s)
      澤井摂
    • Organizer
      第41回臼本臨床検査自動化学会大会
    • Place of Presentation
      パシフィコ横浜
    • Year and Date
      2009-10-10
    • Related Report
      2009 Annual Research Report
  • [Presentation] プロテオーム解析による多発性硬化症、視神経脊髄炎(NMO)の血清再発マーカー探索2009

    • Author(s)
      澤井摂
    • Organizer
      第50回日本神経学会総会
    • Place of Presentation
      仙台国際センター
    • Year and Date
      2009-05-22
    • Related Report
      2010 Final Research Report 2009 Annual Research Report
  • [Patent(Industrial Property Rights)] 多発性硬化症またはNMOの検査マーカーの測定方法2010

    • Inventor(s)
      澤井摂、梅村啓史、森雅裕、桑原聡、野村文夫、清川巌、三浦俊英、小島良、片山勝博
    • Industrial Property Rights Holder
      国立大学法人 千葉大学 外1名
    • Acquisition Date
      2010-04-02
    • Related Report
      2010 Final Research Report

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Published: 2009-04-01   Modified: 2016-04-21  

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