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The role of fatty acid elongation enzyme Elovl6 through cannabinoid receptor in a hippocampus

Research Project

Project/Area Number 21790860
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeSingle-year Grants
Research Field Metabolomics
Research InstitutionUniversity of Tsukuba

Principal Investigator

ISHII Kiyoaki  University of Tsukuba, 大学院・人間総合科学研究科, 助教 (80419150)

Project Period (FY) 2009 – 2010
Project Status Completed (Fiscal Year 2010)
Budget Amount *help
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2010: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2009: ¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000)
Keywordsカンナビノイド / エネルギー代謝 / 脂質 / 海馬
Research Abstract

Influence to proliferation and differentiation was observed by a glia cell and a nerve cell of Elovl6 KO mouse hippocampus. Because 2-AG amount of the endogenous cannabinoid receptor agonist decreases by a hippocampus of KO mouse, a possibility that cannabinoid cascade through 2-AG can consider.

Report

(3 results)
  • 2010 Annual Research Report   Final Research Report ( PDF )
  • 2009 Annual Research Report
  • Research Products

    (8 results)

All 2010 2009 Other

All Journal Article (5 results) (of which Peer Reviewed: 4 results) Presentation (1 results) Remarks (2 results)

  • [Journal Article] The liver-enriched transcription factor CREBH is nutritionally regulated and activated by fatty acids and PPARalpha.2010

    • Author(s)
      Danno H, Ishii KA, Nakagawa Y, Mikami M, Yamamoto T, Yabe S, Furusawa M, Kumadaki S, Watanabe K, Shimizu H, Matsuzaka T, Kobayashi K, Takahashi A, Yatoh S, Suzuki H, Yamada N, Shimano H.
    • Journal Title

      Biochemical and biophysical research communications 391(2)

      Pages: 1222-1227

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] The liver-enriched transcription factor CREBH is nutritionally regulated and activated by fatty acids and PPARalpha2010

    • Author(s)
      Danno H, Ishii KA, Nakagawa Y, Mikami M, Yamamoto T, Yabe S, Furusawa M, et al.
    • Journal Title

      Biochemical and biophysical research communications 391(2)

      Pages: 1222-1227

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] The up-regulation of microRNA-335 is associated with lipid metabolism in liver and white adipose tissue of genetically obese mice.2009

    • Author(s)
      Nakanishi N, Nakagawa Y, Tokushige N, Aoki N, Matsuzaka T, Ishii K, Yahagi N, Kobayashi K, Yatoh S, Takahashi A, Suzuki H, Urayama O, Yamada N, Shimano H.
    • Journal Title

      Biochemical and biophysical research communications 385(4)

      Pages: 492-496

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] PGC-1βと鉄の協調作用による破骨細胞の活性化2009

    • Author(s)
      石井清朗、池田恭治
    • Journal Title

      細胞工学 28

      Pages: 584-585

    • Related Report
      2010 Final Research Report 2009 Annual Research Report
  • [Journal Article] The up-regulation of microRNA-335 is associated with lipid metabolism in liver and white adipose tissue of genetically obese mice2009

    • Author(s)
      Nakanishi N, Nakagawa Y, Tokushige N, Aoki N, Matsuzaka T, Ishii K, et al.
    • Journal Title

      Biochemical and biophysical research communications 385(4)

      Pages: 492-496

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Presentation] ミトコンドリア生合成と破骨細胞活性化におけるPGC-1βと鉄取り込みの協調作用2009

    • Author(s)
      石井清朗
    • Organizer
      細胞シグナル時空間制御機構研究会
    • Place of Presentation
      東京大学
    • Year and Date
      2009-04-25
    • Related Report
      2010 Final Research Report 2009 Annual Research Report
  • [Remarks]

    • URL

      http://www.u-tsukuba-endocrinology.jp/

    • Related Report
      2010 Annual Research Report
  • [Remarks]

    • URL

      http://www.md.tsukuba.ac.jp/clinical-med/endocrinology/research/

    • Related Report
      2009 Annual Research Report

URL: 

Published: 2009-04-01   Modified: 2016-04-21  

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