Secretory membrane endocytosis by the GDP-Rab27a-regulated cytoskeletal modulation
| Project/Area Number |
21790876
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Metabolomics
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| Research Institution | Oita University |
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Principal Investigator |
KIMURA Toshihide Oita University, 医学部, 准教授 (60404373)
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| Project Period (FY) |
2009 – 2010
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| Project Status |
Completed (Fiscal Year 2010)
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| Budget Amount *help |
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2010: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2009: ¥2,600,000 (Direct Cost: ¥2,000,000、Indirect Cost: ¥600,000)
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| Keywords | 低分子量Gタンパク質 / インスリン / 膵B細胞 / エンドサイトーシス / Rab27a / 糖尿病 / アクチン / coronin / エンドサトーシス |
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| Research Abstract |
Insulin is a hormone central to the maintenance of blood glucose levels. Following insulin release, the secretory membranes are taken up for another round of exocytosis. Although the recycling of the secretory membranes is crucial for insulin secretion, the precise molecular mechanisms have not been elucidated. In the present study, we revealed that GDP-Rab27a and its binding proteins regulate this process via cytoskeletal modulation. These molecules involved in the pathway may be a novel therapeutic target for diabetes mellitus.
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Report
(3 results)
Research Products
(39 results)
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[Journal Article] Direct interaction of Slp1 and Rab27 with TrkB receptor regulates its anterograde transport in axons.2009
Author(s)
Arimura N, Kimura T, Nakamuta S, Taya S, Funahashi Y, Hattori A, Shimada A., Menager C., Kawabata S, Fujii K, Iwamatsu A, Segal RA, Fukuda M, Kaibuchi K
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Journal Title
Dev.Cell 16
Pages: 675-686
Related Report
Peer Reviewed
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