Induction of brown adipogenesis of muscle-derived stem cells
Project/Area Number |
21790884
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Research Category |
Grant-in-Aid for Young Scientists (B)
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Allocation Type | Single-year Grants |
Research Field |
Metabolomics
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Research Institution | Fujita Health University |
Principal Investigator |
UEZUMI Akiyoshi 藤田保健衛生大学, 総合医科学研究所, 助教 (60434594)
|
Project Period (FY) |
2009 – 2011
|
Project Status |
Completed (Fiscal Year 2011)
|
Budget Amount *help |
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2011: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2010: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2009: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
|
Keywords | 褐色脂肪細胞 / 骨格筋 / 間葉系幹細胞 / 間葉系前駆細胞 / メタボリックシンドローム |
Research Abstract |
Generation of new brown adipocytes in adult provides a new therapeutic strategy against obesity. We identified mesenchymal stem cells in adult skeletal muscle and showed that these cells possess high brown adipogenic differentiation potential. Muscle-derived mesenchymal stem cells have an independent developmental origin from a classic brown adipose tissue. We also identified these mesenchymal stem cells in adult human skeletal muscle. Finally, we established efficient gene transduction system that enables highly regulated gene expression in mesenchymal stem cells.
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Report
(4 results)
Research Products
(23 results)
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[Journal Article] Fibrosis and adipogenesis originate from common mesenchymal progenitor in skeletal muscle2011
Author(s)
Uezumi A, Ito T, Morikawa D, Shimizu N, Yoneda T, Segawa M, Yamaguchi M, Ogawa R, Milkov M, Miyagoe-Suzuki Y, Takeda S, Tsujikawa K, Tsuchida K, Yamamoto H, Fukada S
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Journal Title
J. Cell Sci.
Volume: 124(21)
Pages: 3654-3664
Related Report
Peer Reviewed
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[Journal Article] Fibrosis and adipogenesis originate from a common mesenchymal progenitor in skeletal muscle2011
Author(s)
Uezumi A, Ito T, Morikawa D, Shimizu N, Yoneda T, Segawa M, Yamaguchi M, Ogawa R, Matev MM, Miyagoe-Suzuki Y, Takeda S, Tsujikawa K, Tsuchida K, Yamamoto H, Fukada S
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Journal Title
J Cell Sci
Volume: 124(21)
Issue: 21
Pages: 3654-3664
DOI
Related Report
Peer Reviewed
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[Journal Article] Hesr1 and Hesr3 are essential to generate undifferentiated quiescent satellite cells and to maintain satellite cell numbers2011
Author(s)
F ukada S, Yamaguchi M, Kokubo H, Ogawa R, Uezumi A, Yoneda T, Matev MM, Motohashi N, Ito T, Zolkiewska A, Johnson RL, Saga Y, Miyagoe-Suzuki Y, Tsujikawa K, Takeda S, Yamamoto H
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Journal Title
Development
Volume: 138
Issue: 21
Pages: 4609-4619
DOI
Related Report
Peer Reviewed
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