Mechanism of energy metabolism in white ad i pose tissue via hypothalamus and sympathetic nervous system

• Project/Area Number: 21790898
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Single-year Grants
• Research Field: Endocrinology
• Research Institution: National Institute for Physiological Sciences
• Principal Investigator: SHIUCHI Tetsuya National Institute for Physiological Sciences, 大学院・ヘルスバイオサイエンス研究部, 講師 (70372729)
• Project Period (FY): 2009 – 2010
• Project Status: Completed (Fiscal Year 2010)
• Budget Amount: ¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000); Fiscal Year 2010: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000); Fiscal Year 2009: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
• Keywords: 白色脂肪組織 / メラノコルチン系 / 交感神経系 / 炎症性サイトカイン / βアドレナリン受容体 / 中枢神経系 / メラノコルチン受容体

Research Abstract

This study investigated effect of melanocortin receptor blockade on expression of inflammatory cytokine in white adipose tissue (WAT). Results suggest that i.c.v. administration of agouti-related protein acutely increases the proinflammatory cytokine expression such as TNF・in epididymal WAT via the attenuation of sympathetic nerve activity innervating the tissue and stimulation of beta-adrenergic receptor, without any change in the tissue hypertrophy and food intake.

Research Products

• [Journal Article] Decreased Intake of Sucrose Solutions in Orexin Knockout Mice. (2011)
  • Author(s): Matsuo E, Mochizuki A, Nakayama K, Nakamura S, Yamamoto T, Shioda S, Sakurai T, Yanagisawa M, Shiuchi T, Minokoshi Y, Inoue T.
  • Journal Title: J Mol Neurosci. 43(2) Pages: 217-224
• [Journal Article] Lack of TRPM2 Impaired Insulin Secretion and Glucose Metabolisms in Mice. (2011)
  • Author(s): Uchida K, Dezaki K, Damdindorj B, Inada H, Shiuchi T, Mori Y, Yada T, Minokoshi Y, Tominaga M.
  • Journal Title: Diabetes. 60(1) Pages: 119-126
• [Journal Article] Induction of Hypothalamic Sirt1 Leads to Cessation of Feeding via Agouti-Related Peptide. (2011)
  • Author(s): Sasaki T, Kim HJ, Kobayashi M, Kitamura YI, Yokota-Hashimoto H, Shiuchi T, Minokoshi Y, Kitamura T.
  • Journal Title: Endocrinology. 151(6) Pages: 2556-2566
• [Journal Article] An enzymatic photometric assay for 2-deoxyglucose uptake in insulin-responsive tissues and 3T3-L1 adipocytes. (2011)
  • Author(s): Saito K, et al.
  • Journal Title: Anal Biochem. Volume: 412 Pages: 9-17
  • Peer Reviewed
• [Journal Article] Decreased intake of sucrose solutions in orexin knockout mice. (2011)
  • Author(s): Matsuo E, et al.
  • Journal Title: J Mol Neurosci. Volume: 43 Pages: 217-24
  • Peer Reviewed
• [Journal Article] Metabolic adaptation of mice in a cool environment. (2010)
  • Author(s): Uchida K, Shiuchi T, Inada H, Minokoshi Y, Tominaga M.
  • Journal Title: Pflugers Arch. 459(5) Pages: 765-774
• [Journal Article] Lack of TRPM2 impaired insulin secretion and glucose metabolisms in mice. (2010)
  • Author(s): Uchida K, et al.
  • Journal Title: Diabetes. Volume: 60 Pages: 119-26
  • Peer Reviewed
• [Journal Article] Induction of hypothalamic Sirt1 leads to cessation of feeding via agouti-related peptide. (2010)
  • Author(s): Sasaki T, et al.
  • Journal Title: Endocrinology. Volume: 151 Pages: 2556-66
  • Peer Reviewed
• [Journal Article] Metabolic adaptation of mice in a cool environment. (2010)
  • Author(s): Uchida K, et al.
  • Journal Title: Pflugers Arch. Volume: 459 Pages: 765-74
  • Peer Reviewed
• [Journal Article] Hypothalamic orexin stimulates feeding-associated glucose utilization in skeletal muscle via sympathetic nervous system. (2009)
  • Author(s): Shiuchi T, Haque MS, Okamoto S, Inoue T, Kageyama H, Lee S, Toda C, Suzuki A, Bachman ES, Kim YB, Sakurai T, Yanagisawa M, Shioda S, Imoto K, Minokoshi Y.
  • Journal Title: Cell Metab. 10(6) Pages: 466-480
• [Journal Article] Distinct effects of leptin and a melanocortin receptor agonist injected into medial hypothalamic nuclei on glucose uptake in peripheral tissues. (2009)
  • Author(s): Toda C, Shiuchi T, Lee S, Yamato-Esaki M, Fujino Y, Suzuki A, Okamoto S, Minokoshi Y.
  • Journal Title: Diabetes. 58(12) Pages: 2757-2765
• [Journal Article] Hypothalamic orexin stimulates feeding-associated glucose utilization in skeletal muscle via sympathetic nervous system (2009)
  • Author(s): Shiuchi T.et al.
  • Journal Title: Cell Metabolism 10 Pages: 466-480
  • Peer Reviewed
• [Presentation] 中枢レプチン投与後の骨格筋でのグルコース取り込みにおけるAMPKの関与 (2010)
  • Author(s): 志内哲也
  • Organizer: 日本体力医学会
  • Place of Presentation: 千葉商科大学(千葉県)
  • Year and Date: 2010-09-17
• [Presentation] オレキシンによる交感神経を介した糖代謝調節メカニズム (2010)
  • Author(s): 志内哲也
  • Organizer: 第3回脳・神経・内分泌系から運動の意義を考える会
  • Place of Presentation: 和洋女子大学・千葉(招待講演)
  • Year and Date: 2010-09-15
• [Presentation] オレキシンによる交感神経を介した糖代謝調節メカニズム (2010)
  • Author(s): 志内哲也
  • Organizer: 脳・神経・内分泌系から運動の意義を考える会
  • Place of Presentation: 和洋女子大学(千葉県)
  • Year and Date: 2010-09-15
• [Presentation] Feeding-associated glucose metabolism in skeletal muscle via hypothalamic orexin system (2010)
  • Author(s): Tetsuya Shiuchi
  • Organizer: 日本味と匂学会
  • Place of Presentation: 北九州国際会議場(福岡県)
  • Year and Date: 2010-09-08
• [Presentation] Hypothalamic orexin stimulates feeding associated glucose metabolism in skeletal muscle via sympathetic nervous system (2010)
  • Author(s): Tetsuya Shiuchi
  • Organizer: International Congress of Obesity
  • Place of Presentation: Stockholm (Sweden)
  • Year and Date: 2010-07-12
• [Presentation] 視床下部オレキシンによる骨格筋糖代謝調節作用 (2010)
  • Author(s): 志内哲也
  • Organizer: 第2回分子骨格筋代謝研究会
  • Place of Presentation: 京都大学・京都(招待講演)
  • Year and Date: 2010-05-22
• [Presentation] 視床下部オレキシンによる骨格筋糖代謝調節作用 (2010)
  • Author(s): 志内哲也
  • Organizer: 分子骨格筋代謝研究会
  • Place of Presentation: 京都大学(京都府)
  • Year and Date: 2010-05-22
• [Presentation] Hypothalamic orexin regulates feeding associated glucose metabolism in skeletal muscle via sympathetic nervous system (2010)
  • Author(s): Tetsuya Shiuchi
  • Organizer: 日本生理学会
  • Place of Presentation: 盛岡市民文化ホール(岩手県)
  • Year and Date: 2010-05-21
• [Presentation] レプチン中枢投与後の骨格筋におけるグルコース取込みとAMPK の調節作用 (2010)
  • Author(s): 志内哲也、三浦進司、江崎治、箕越靖彦
  • Organizer: 第31回日本肥満学会
  • Place of Presentation: 前橋テルサ・群馬
• [Presentation] 中枢レプチン投与後の骨格筋でのグルコース取込みにおけるAMPKの関与 (2010)
  • Author(s): 志内哲也、三浦進司、江崎治
  • Organizer: 第65回日本体力医学会
  • Place of Presentation: 千葉商科大学、和洋女子大学・千葉
• [Presentation] Feeding-associated glucose metabolism in skeletal muscle via hypothalamic orexin system, "食調節に関わるtaste-brain-gut axis の最前線" (2010)
  • Author(s): Tetsuya Shiuchi、Yasuhiko Minokoshi
  • Organizer: 第44回日本味と匂学会大会
  • Place of Presentation: 北九州国際会議場・福岡 シンポジウム
• [Presentation] Hypothalamic orexin stimulates feeding-associated glucose metabolism in skeletal muscle via sympathetic nervous system (2010)
  • Author(s): Tetsuya Shiuchi, Shiki Okamoto, Chitoku Toda, Yasuhiko Minokoshi
  • Organizer: The 11th International Congress of Obesity
  • Place of Presentation: Stockholm・Sweden
• [Presentation] Hypothalamic orexin regulates feeding-associated glucose metabolism in skeletal muscle via sympathetic nervous system (2010)
  • Author(s): Tetsuya Shiuchi, Shiki Okamoto, Chitoku Toda, Yasuhiko Minokoshi
  • Organizer: 日本生理学会
  • Place of Presentation: 盛岡市民文化ホール・岩手
• [Presentation] 視床下部オレキシンによる骨格筋での糖代謝調節と動機付け摂食行動との作用連関 (2010)
  • Author(s): 志内哲也
  • Organizer: 生理研研究会
  • Place of Presentation: 岡崎カンファレンスセンター・愛知
• [Presentation] 視床下部オレキシンー交感神経系による骨格筋でのグルコース代謝調節作用 (2009)
  • Author(s): 志内哲也
  • Organizer: 第62回 日本自律神経学会
  • Place of Presentation: 和歌山県和歌山市 ロイネットホテル和歌山
  • Year and Date: 2009-11-05
• [Presentation] Orexin enhances glucose metabolism in skeletal muscle via mediobasal hypothalamus-sympathetic nerve and β2-adrenergic pathway (2009)
  • Author(s): 志内哲也
  • Organizer: 第36回国際生理学会
  • Place of Presentation: 京都府京都市 国際京都会館
  • Year and Date: 2009-07-29
• [Presentation] 視床下部オレキシン-交感神経系による骨格筋でのグルコース代謝調節作用 (2009)
  • Author(s): 志内哲也、箕越靖彦
  • Organizer: 摂食・代謝調節の分子機構-中枢と末梢のクロストーク第62回日本自律神経学会総会
  • Place of Presentation: ロイネットホテル和歌山・和歌山 シンポジウム
• [Presentation] 骨格筋でのグルコース代謝に及ぼす視床下部オレキシンの調節作用 (2009)
  • Author(s): 箕越靖彦、志内哲也
  • Organizer: エネルギー代謝と肥満症第30回日本肥満学会
  • Place of Presentation: アクトシティ浜松・静岡 シンポジウム
• [Presentation] Orexins enhance glucose metabolism in skeletal muscle via mediobasal hypothalamus-sympathetic nerve and #NAME (2009)
  • Author(s): Tetsuya Shiuchi, Atsushi Suzuki, Suni Lee, Chitoku Toda, Shiki Okamoto, Yasuhiko Minokoshi.
  • Organizer: The 36th International Union of Physiological Sciences
  • Place of Presentation: Kyoto・Japan
• [Presentation] 骨格筋での糖代謝調節におけるオレキシンの作用機序 (2009)
  • Author(s): 志内哲也
  • Organizer: 第5回GPCR研究会
  • Place of Presentation: 日本科学未来館・東京(招待講演)
• [Book] Annual Review糖尿病・代謝・内分泌 視床下部を介したエネルギー代謝調節機構 (2011)
  • Author(s): 志内哲也・箕越靖彦
  • Publisher: 中外医学社 印刷中
• [Book] 糖尿病学 視床下部オレキシンによる骨格筋でのグルコース利用促進機構 (2010)
  • Author(s): 志内哲也・箕越靖彦
  • Publisher: 診断と治療社
• [Book] 体育の科学 Vol.59 No.7 視床下部による血糖レベルの調節 (2009)
  • Author(s): 志内哲也・箕越靖彦
  • Publisher: 杏林書院
• [Remarks] ホームページ等