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Effects of iron-overload on normal hematopoiesis and disease progression of hamatological malignancies

Research Project

Project/Area Number 21790914
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeSingle-year Grants
Research Field Hematology
Research InstitutionOsaka University

Principal Investigator

TANAKA Hirokazu  Osaka University, 医学系研究科, 助教 (40360846)

Project Period (FY) 2009 – 2010
Project Status Completed (Fiscal Year 2010)
Budget Amount *help
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2010: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2009: ¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000)
Keywords過剰鉄 / 造血幹細胞 / ストローマ細胞 / 活性酸素種 / 造血器腫瘍 / 造血 / 鉄過剰
Research Abstract

In this study, we conducted the analyses regarding how does excessive "free"iron affect the growth and differentiation of hematopoietic cells as well as the characteristic of hematopoietic stromal cells.In addition, we investigated the effects of iron overload on the proliferation of MDS clones and the pathological transformation of MDS. As a result, excessive iron impairs hematopoiesis through direct effects on hematopoietic cells and indirect effects mediated by stromal cells. Furthermore, iron overload may induce the selective proliferation of MDS clones during the deterioration of normal hematopoiesis and may be involved in the leukemic transformation. These results are significant to reveal the mechanism and treatment of various hematopoietic disorders in terms of iron-kinetics.

Report

(3 results)
  • 2010 Annual Research Report   Final Research Report ( PDF )
  • 2009 Annual Research Report
  • Research Products

    (46 results)

All 2011 2010 2009

All Journal Article (11 results) (of which Peer Reviewed: 10 results) Presentation (35 results)

  • [Journal Article] Myeloid neoplasm-related gene Abnormalities differentially affect dendritic cell differentiation from murine hematopoietic stem/progenitor cells.2011

    • Author(s)
      Fujita J, Tanaka H, Satoh Y, Fukushima K, Tokunaga M, Matsumura I, Kanakura Y.
    • Journal Title

      Immunol Lett. 136(1)

      Pages: 61-73

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] A cell-death-defying factor, anamorsin mediates cell growth through inactivation of PKC and p38MAPK.2011

    • Author(s)
      Saito Y, Shibayama H, Tanaka H, Tanimura A, Kanakura Y.
    • Journal Title

      Biochem Biophys Res Commun. 405(2)

      Pages: 303-307

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] A cell-death-defying factor, anamorsin mediates cell growth through inactivation of PKC and p38MAPK.2011

    • Author(s)
      Saito Y, Tanaka H, et al.
    • Journal Title

      Biochem Biophys Res Commun.

      Volume: 405(2) Pages: 303-307

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] A case of non-cardiogenic acute pulmonary edema in a patient with POEMS syndrome-associated pulmonary arterial hypertension.2010

    • Author(s)
      Hara M, Mizote I, Nakaoka Y, Tanaka H, Asano Y, Sakata Y, Komuro I.
    • Journal Title

      Ann Hematol. 90(4)

      Pages: 489-490

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Sildenafil and steroid therapy effectively improved POEMS syndrome-associated pulmonary arterial hypertension.2010

    • Author(s)
      Shimomura Y, Hara M, Mizote I, Nakaoka Y, Tanaka H, Asano Y, Sakata Y, Komuro I.
    • Journal Title

      Int J Hematol. 92(5)

      Pages: 774-776

    • NAID

      10027674619

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] BCR-ABL but not JAK2 V617F inhibits erythropoiesis through the Ras signal by inducing p21CIP1/WAF1.2010

    • Author(s)
      Tokunaga M, Ezoe S, Tanaka H, Satoh Y, Fukushima K, Matsui K, Shibata M, Tanimura A, Oritani K, Matsumura I, Kanakura Y.
    • Journal Title

      J Biol Chem. 285(41)

      Pages: 30045-30056

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] BCR-ABL but not JAK2 V617F inhibits erythropoiesis through the Rassignal by inducing p21^<CIP1/WAF1>2010

    • Author(s)
      Tokunaga M, Tanaka H, et al.
    • Journal Title

      J Biol Chem.

      Volume: 285 Pages: 31774-31782

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Sildenafil and steroid therapy effectively improved POEMS syndrome-associated pulmonary arterial hypertension.2010

    • Author(s)
      Shimomura Y,, Tanaka H, et al.
    • Journal Title

      Int J Hematol.

      Volume: 92 Pages: 774-776

    • NAID

      10027674619

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] FIP1L1-PDGFRalpha imposes eosinophil lineage commitment on hematopoietic stem/progenitor cells.2009

    • Author(s)
      Fukushima K, Matsumura I, Ezoe S, Tokunaga M, Yasumi M, Satoh Y, Shibayama H, Tanaka H, Iwama A, Kanakura Y.
    • Journal Title

      J Biol Chem. 284(12)

      Pages: 7719-7732

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] 白血病幹細胞研究の動向2009

    • Author(s)
      田中宏和, 松村到, 金倉譲
    • Journal Title

      Biotherapy 23

      Pages: 364-370

    • Related Report
      2010 Final Research Report 2009 Annual Research Report
  • [Journal Article] FIP1L1-PDGFRalpha imposes eosinophil lineage commitment on hematopoietic stem/progenitor cells2009

    • Author(s)
      Fukushima K, Matsumura I, Tanaka H, Kanakura Y., et al.
    • Journal Title

      J Biol Chem 284

      Pages: 7719-7732

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Presentation] A chromatin modifier SATB1 promotes lymphocyte production from primitive hematopoietic stem/progenitor cells.2010

    • Author(s)
      Satoh Y, Tanaka H, et al.
    • Organizer
      The American Society of Hematology 52nd Annual meeting.
    • Place of Presentation
      Orlando (USA)
    • Related Report
      2010 Final Research Report
  • [Presentation] Myeloid neoplasm-related gene abnormalities differentially affect FLT3-ligand mediated dendritic cell differentiation from murine hematopoietic stem/progenitor cells.2010

    • Author(s)
      Satoh Y, Tanaka H, et al.
    • Organizer
      The American Society of Hematology 52nd Annual meeting.
    • Place of Presentation
      Orlando (USA)
    • Related Report
      2010 Final Research Report
  • [Presentation] Iron-overload impairs normal hematopoiesis and would contribute to disease progression of MDS.2010

    • Author(s)
      Tanaka H, Matsumura I, Kanakura Y, et al.
    • Organizer
      第72回日本血液学会学術集会
    • Place of Presentation
      パシフィコ横浜、神奈川
    • Related Report
      2010 Final Research Report
  • [Presentation] Leukemia-related gene abnormalities affect FLT3-ligand-mediated dendritic cell differentiation.2010

    • Author(s)
      藤田二郎, 田中宏和, 他
    • Organizer
      第72回日本血液学会学術集会
    • Place of Presentation
      パシフィコ横浜、神奈川
    • Related Report
      2010 Final Research Report
  • [Presentation] BCR-ABLは下流のRasシグナルを介して赤芽球造血を抑制し、その抑制にはp21CIP1/WAF1が関与する.2010

    • Author(s)
      徳永正浩, 田中宏和, 他
    • Organizer
      第72回日本血液学会学術集会
    • Place of Presentation
      パシフィコ横浜、神奈川
    • Related Report
      2010 Final Research Report
  • [Presentation] Anti-apoptotic molecule Anamorsin is crucial for stromal function to support embryonic hematopoiesis.2010

    • Author(s)
      Tanimura A, Tanaka H, et al.
    • Organizer
      第72回日本血液学会学術集会
    • Place of Presentation
      パシフィコ横浜、神奈川
    • Related Report
      2010 Final Research Report
  • [Presentation] AML幹細胞の特性解析2010

    • Author(s)
      松村到, 田中宏和
    • Organizer
      第69回日本癌学会学術総会(招待講演)
    • Place of Presentation
      大阪国際会議場、大阪
    • Related Report
      2010 Final Research Report
  • [Presentation] Effects of iron-overload on normal hematopoiesis and disease progression of myeloid malignancies.2010

    • Author(s)
      Tanaka H, et al.
    • Organizer
      第69回日本癌学会学術総会
    • Place of Presentation
      大阪国際会議場、大阪
    • Related Report
      2010 Final Research Report
  • [Presentation] Leukemia-related gene abnormalities affect steady-state dendritic cell differentiation.2010

    • Author(s)
      藤田二郎, 田中宏和, 他
    • Organizer
      第69回日本癌学会学術総会
    • Place of Presentation
      大阪国際会議場、大阪
    • Related Report
      2010 Final Research Report
  • [Presentation] The activated Ras signal suppresses erythropoiesis downstream of Bcr-Abl by inducing p21CIP1/WAF1.2010

    • Author(s)
      徳永正浩, 田中宏和, 他
    • Organizer
      第69回日本癌学会学術総会
    • Place of Presentation
      大阪国際会議場、大阪
    • Related Report
      2010 Final Research Report
  • [Presentation] A cell-death-defying factor, anamorsin, yields cell growth through inactivation of p38MAPK.2010

    • Author(s)
      齋藤有理, 田中宏和, 他
    • Organizer
      第69回日本癌学会学術総会
    • Place of Presentation
      大阪国際会議場、大阪
    • Related Report
      2010 Final Research Report
  • [Presentation] Excessive reactive iron affects both immature hematopoietic cells and stromal cells, thereby impairing total hematopoiesis.2010

    • Author(s)
      Tanaka H, et al.
    • Organizer
      1st JSH International Symposium
    • Place of Presentation
      Akita University, Akita
    • Related Report
      2010 Final Research Report
  • [Presentation] BCR-ABL but not JAK2 V617F inhibits erythropoiesis through the Ras signal by inducing2010

    • Author(s)
      Tokunaga M, Tanaka H, et al.
    • Organizer
      p21CIP1/WAF1 15th Congress of the European Hematology Association
    • Place of Presentation
      Barcelona (Spain)
    • Related Report
      2010 Final Research Report
  • [Presentation] Essential role of an anti-apoptotic molecule Anamorsin for both intrinsic and extrinsic regulation of murine fetal liver hematopoiesis.2010

    • Author(s)
      Tanimura A, Tanaka H, et al.
    • Organizer
      15th Congress of the European Hematology Association
    • Place of Presentation
      Barcelona (Spain)
    • Related Report
      2010 Final Research Report
  • [Presentation] BCR-ABL but not JAK2 V617F inhibits erythropoiesis through the Rassignal by inducing p21^<CIP1/WAF1>2010

    • Author(s)
      Tokunaga M, Tanaka H, et al.
    • Organizer
      15th Congress of the European Hematology Association
    • Place of Presentation
      BICC, Barcelona (Spain)
    • Related Report
      2010 Annual Research Report
  • [Presentation] Essential role of an anti-apoptotic molecule Anamorsin for both intrinsic and extrinsic regulation of murine fetal liver hematopoiesis2010

    • Author(s)
      Tanimura A, Tanaka H, et al.
    • Organizer
      15th Congress of the European Hematology Association
    • Place of Presentation
      BICC, Barcelona (Spain)
    • Related Report
      2010 Annual Research Report
  • [Presentation] Excessive reactive iron affects both immature hematopoietic cells and stromal cells, thereby impairing total hematopoiesis2010

    • Author(s)
      Tanaka H, et al.
    • Organizer
      1st JSH International Symposium
    • Place of Presentation
      Akita University, Akita
    • Related Report
      2010 Annual Research Report
  • [Presentation] A chromatin modifier SATB1 promotes lymphocyte production from primitive hematopoietic stem/progenitor cells2010

    • Author(s)
      Satoh Y, Tanaka H, et al.
    • Organizer
      The American Society of Hematology 52nd Annual meeting
    • Place of Presentation
      OCCC, Orlando (USA)
    • Related Report
      2010 Annual Research Report
  • [Presentation] Myeloid neoplasm-related gene abnormalities differentially affect FLT3-ligand mediated dendritic cell differentiation from murine hematopoietic stem/progenitor cells2010

    • Author(s)
      Fujita J, Tanaka H, et al.
    • Organizer
      The American Society of Hematology 52nd Annual meeting
    • Place of Presentation
      OCCC, Orlando (USA)
    • Related Report
      2010 Annual Research Report
  • [Presentation] AML幹細胞の特性解析2010

    • Author(s)
      松村到, 田中宏和
    • Organizer
      第69回日本癌学会学術総会
    • Place of Presentation
      大阪国際会議場、大阪(招待講演)
    • Related Report
      2010 Annual Research Report
  • [Presentation] Effects of iron-overload on normal hematopoiesis and disease progression of myeloid malignancies2010

    • Author(s)
      Tanaka H, et al.
    • Organizer
      第69回日本癌学会学術総会
    • Place of Presentation
      大阪国際会議場、大阪
    • Related Report
      2010 Annual Research Report
  • [Presentation] Leukemia-related gene abnormalities affect steady-state dendritic cell differentiation2010

    • Author(s)
      藤田二郎, 田中宏和, 他
    • Organizer
      第69回日本癌学会学術総会
    • Place of Presentation
      大阪国際会議場、大阪
    • Related Report
      2010 Annual Research Report
  • [Presentation] The activated Ras signal suppresses erythropoiesis downstream of Bcr-Abl by inducing P21^<CIP1/WAF1>2010

    • Author(s)
      徳永正浩, 田中宏和, 他
    • Organizer
      第69回日本癌学会学術総会
    • Place of Presentation
      大阪国際会議場、大阪
    • Related Report
      2010 Annual Research Report
  • [Presentation] A cell-death-defying factor, anamorsin, yields cell growth through inactivation of p38MAPK2010

    • Author(s)
      齋藤有里, 田中宏和, 他
    • Organizer
      第69回日本癌学会学術総会
    • Place of Presentation
      大阪国際会議場、大阪
    • Related Report
      2010 Annual Research Report
  • [Presentation] Iron-overload impairs normal hematopoiesis and would contribute to disease progression of MDS2010

    • Author(s)
      Tanaka H, Matsumura I, Kanakura Y, et al.
    • Organizer
      第72回日本血液学会学術集会
    • Place of Presentation
      ハシフィコ横浜、神奈川
    • Related Report
      2010 Annual Research Report
  • [Presentation] Leukemia-related gene abnormalities affect FLT3-ligand-mediated dendritic cell differentiation2010

    • Author(s)
      藤田二郎, 田中宏和, 他
    • Organizer
      第72回日本血液学会学術集会
    • Place of Presentation
      パシフィコ横浜、神奈川
    • Related Report
      2010 Annual Research Report
  • [Presentation] BCR-ABLは下流のRasシグナルを介して赤芽球造血を抑制し、その抑制にはp21CIP1/WAF1が関与する2010

    • Author(s)
      徳永正浩, 田中宏和, 他
    • Organizer
      第72回日本血液学会学術集会
    • Place of Presentation
      パシフィコ横浜、神奈川
    • Related Report
      2010 Annual Research Report
  • [Presentation] Anti-apoptotic molecule Anamorsin is crucial for stromal function to support embryonic hematopoiesis2010

    • Author(s)
      Tanimura A, Tanaka H, et al.
    • Organizer
      第72回日本血液学会学術集会
    • Place of Presentation
      パシフィコ横浜、神奈川
    • Related Report
      2010 Annual Research Report
  • [Presentation] 鉄代謝異常と内科系疾患2009

    • Author(s)
      田中宏和
    • Organizer
      第9回内科系セミナー
    • Place of Presentation
      大阪
    • Year and Date
      2009-09-17
    • Related Report
      2009 Annual Research Report
  • [Presentation] C-terminal mutation of RUNX1 deteriorates DNA damage-repair response and promotes the development of acute myeloid leukemia.2009

    • Author(s)
      Satoh S, Tanaka H, et al.
    • Organizer
      The American Society of Hematology 51st Annual Meeting.
    • Place of Presentation
      New Orleans (USA)
    • Related Report
      2010 Final Research Report
  • [Presentation] RUNX1 controls nucleotide excision repair (NER) system through transcriptional regulation of Gadd45a.2009

    • Author(s)
      Satoh S, Tanaka H, et al.
    • Organizer
      第71回日本血液学会学術集会
    • Place of Presentation
      京都国際会議場、京都
    • Related Report
      2010 Final Research Report
  • [Presentation] 抗アポトーシス分子Anamorsinの造血幹細胞における発現と機能解析2009

    • Author(s)
      谷村朗, 田中宏和, 他
    • Organizer
      第71回日本血液学会学術集会
    • Place of Presentation
      京都国際会議場、京都
    • Related Report
      2010 Final Research Report
  • [Presentation] 組織鉄の功罪:骨髄における過剰鉄がもたらす毒性.2009

    • Author(s)
      松村到, 田中宏和, 金倉譲
    • Organizer
      第33回鉄バイオサイエンス学会
    • Place of Presentation
      倉敷市民会館、岡山
    • Related Report
      2010 Final Research Report
  • [Presentation] C-terminal mutation of RUNX1 deteriorates DNA damage-repair response and promotes the development of acute myeloid leukemia2009

    • Author(s)
      Satoh S, Matsumura I, Tanaka H, Harada H, Harada Y, Kanakura Y.
    • Organizer
      The American Society of Hematology 51st Annual Meeting
    • Place of Presentation
      New Orleans, USA
    • Related Report
      2009 Annual Research Report
  • [Presentation] 組織鉄の功罪:髄における過剰鉄がもたらす毒性2009

    • Author(s)
      松村到, 田中宏和, 金倉譲
    • Organizer
      第33回鉄バイオサイエンス学会
    • Place of Presentation
      岡山
    • Related Report
      2009 Annual Research Report

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Published: 2009-04-01   Modified: 2016-04-21  

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