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Host defense against myelo -suppressive stress

Research Project

Project/Area Number 21790923
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeSingle-year Grants
Research Field Hematology
Research InstitutionKeio University

Principal Investigator

MIYAMOTO Kana  Keio University, 医学部, 研究員 (60464997)

Project Period (FY) 2009 – 2010
Project Status Completed (Fiscal Year 2010)
Budget Amount *help
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2010: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2009: ¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000)
Keywords血液内科学 / 破骨細胞 / 骨髄抑制 / 骨髄腔 / 造血 / 分化 / MCP-1
Research Abstract

The maintenance of haematopoietic stem cells and mobilization of haematopoietic progeniyor cells to the periphery is very important for lives. It was reported that bone marrow cavities and osteoclasts are required for maintenance of haematopoietic stem cells and mobilization of bone marrow cells to periphery, respectively. In this study, we found that bone marrow cavities and osteoclasts were both dispensable for the maintenance of haematopoietic stem cells and mobilization of bone marrow cells to p eriphery.

Report

(3 results)
  • 2010 Annual Research Report   Final Research Report ( PDF )
  • 2009 Annual Research Report
  • Research Products

    (7 results)

All 2010 2009

All Journal Article (3 results) (of which Peer Reviewed: 3 results) Presentation (4 results)

  • [Journal Article] The Blimp1-Bcl6 axis is critical to regulate osteoclast differentiation and bone homeostasis.2010

    • Author(s)
      Miyauchi Y, Ninomiya K, Miyamoto H, Sakamoto A, Iwasaki R, Hoshi H, Miyamoto K, Hao W, Yoshida S, Morioka H, Chiba K, Kato S, Tokuhisa T, Saitou M, Toyama Y, Suda T, Miyamoto T.
    • Journal Title

      J Exp Med. 207(4)

      Pages: 751-762

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] MCP-1 expressed by osteoclasts stimulates osteoclastogenesis in an autocrine/paracrine manner.2009

    • Author(s)
      Miyamoto K, Ninomiya K, Sonoda K, Miyauchi Y, Hoshi H, Iwasaki R, Miyamoto H, Yoshida S, Sato Y, Morioka H, Chiba K, Egarashi K, Suda T, Toyama Y, Miyamoto T.
    • Journal Title

      Biochem Biophys Res Commun. 383

      Pages: 373-377

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] MCP-1 expressed by osteoclasts stimulates osteoclastogenesis in an autocrine/paracrine manner2009

    • Author(s)
      Miyamoto K., et al.
    • Journal Title

      Biochem Biophys Res Commun 383

      Pages: 373-377

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Presentation] Osteoclasts as negative regulators of the hemaopoietic microenvironment.2010

    • Author(s)
      Kana Miyamoto, Yoshiaki Toyama, Takeshi Miyamoto.
    • Organizer
      第72回日本血液学会学術集会
    • Place of Presentation
      パシフィコ横浜
    • Related Report
      2010 Final Research Report
  • [Presentation] Osteoclasts as negative regulators of the hemaopoietic microenvironment2010

    • Author(s)
      Kana Miyamoto, Yoshiaki Toyama, Takeshi Miyamoto
    • Organizer
      第72回日本血液学会学術集会
    • Place of Presentation
      横浜
    • Related Report
      2010 Annual Research Report
  • [Presentation] MCP-1 expressed by osteoclasts stimulates osteoclastogenesis in an autocrine/paracrine manner.2009

    • Author(s)
      Kana Miyamoto, Takeshi Miyamoto, Toshio Suda, Yoshiaki Toyama.
    • Organizer
      第71回日本血液学会学術集会
    • Place of Presentation
      国立京都国際会館
    • Related Report
      2010 Final Research Report
  • [Presentation] MCP-1 expressed by osteoclasts stimulates osteoclastogenesis in an autocrine/paracrine manner2009

    • Author(s)
      宮本佳奈, 他
    • Organizer
      第71回日本血液学会学術集会
    • Place of Presentation
      京都
    • Related Report
      2009 Annual Research Report

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Published: 2009-04-01   Modified: 2016-04-21  

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