A comprehensive association study of IRF family genes in genetic predisposition to connective tissue diseases.
Project/Area Number |
21790935
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Research Category |
Grant-in-Aid for Young Scientists (B)
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Allocation Type | Single-year Grants |
Research Field |
膠原病・アレルギー・感染症内科学
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Research Institution | University of Tsukuba |
Principal Investigator |
KAWASAKI Aya University of Tsukuba, 大学院・人間総合科学研究科, 研究員 (30532816)
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Research Collaborator |
TSUCHIYA Naoyuki 筑波大学, 大学院・人間総合科学研究科, 教授 (60231437)
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Project Period (FY) |
2009 – 2010
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Project Status |
Completed (Fiscal Year 2010)
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Budget Amount *help |
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2010: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2009: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
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Keywords | 全身性エリテマトーデス / 疾患感受性遺伝子 / インターフェロン / IRF / SNP / TLR / 膠原病 / 関連研究 / 遺伝子 |
Research Abstract |
We examined whether IRF and TLR related genes contribute to the susceptibility to systemic lupus erythematosus (SLE). Association of IRF7 and TLR7 essential for the induction of type I interferon was detected in Japanese. A single nucleotide polymorphism (SNP) located closely to IRF7 was associated with the presence of anti-Sm antibodies and renal disorder in SLE. In addition, SNPs in TLR7 3' untranslated region and intron were associated with SLE independently. Association of TNFAIP3 and TNIP1 was also observed.
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Report
(3 results)
Research Products
(21 results)
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[Journal Article] TLR7 single-nucleotide polymorphisms in the 3' untranslated region and intron 2 independently contribute to systemic lupus erythematosus in Japanese women : a case-control association study2011
Author(s)
Kawasaki A, Furukawa H, Kondo Y, Ito S, Hayashi T, Kusaoi M, Matsumoto I, Tohma S, Takasaki Y, Hashimoto H, Sumida T, Tsuchiya N
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Journal Title
Arthritis Res Ther Vol.13
NAID
Related Report
Peer Reviewed
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[Journal Article] Association of TNFAIP3 interacting protein 1, TNIP1 with systemic lupus erythematosus in a Japanese population : a case-control association study2010
Author(s)
Kawasaki A, Ito S, Furukawa H, Hayashi T, Goto D, Matsumoto I, Kusaoi M, Ohashi J, Graham RR, Matsuta K, Behrens TW, Tohma S, Takasaki Y, Hashimoto H, Sumida T, Tsuchiya N
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Journal Title
Arthritis Res Ther Vol.12
Related Report
Peer Reviewed
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