Function analysis of autoantigens in human mature osteoclast from rheumatoid arthritis patient under anti-rheumatic drugs.
| Project/Area Number |
21790946
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
膠原病・アレルギー・感染症内科学
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| Research Institution | Kyoto University |
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Principal Investigator |
NOJIMA Takaki Kyoto University, 医学研究科, 助教 (30327514)
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| Project Period (FY) |
2009 – 2010
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| Project Status |
Completed (Fiscal Year 2010)
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| Budget Amount *help |
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2010: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2009: ¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000)
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| Keywords | 破骨細胞 / 自己抗原 / 関節リウマチ |
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| Research Abstract |
In osteoclastgenesis system using human peripheral-blood mononuclear cells, we found that calpastatin was cut off and calpain revitalization was elevated from 3 day to 6 day. The protein level changes of calpain 1 and calpain 2 were not detected in our osteoclastgenesis system. Cell permeable calpastatin down-regulated the osteoclastgenesis and the bone absorptivity of human osteoclast. After 15 minutes TNFα (100ng/ml) stimulation, calpain revitalization elevated in human osteoclast.
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Report
(3 results)
Research Products
(27 results)
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[Journal Article] Anti-citrullinated peptide antibody-negative RA is a genetically distinct subset : a definitive study using only bone-erosive ACPA-negative rheumatoid arthritis.2010
Author(s)
Ohmura K, Terao C, Maruya E, Katayama M, Matoba K, Shimada K, Murasawa A, Honjo S, Takasugi K, Tohma S, Matsuo K, Tajima K, Yukawa N, Kawabata D, Nojima T, Fujii T, Yamada R, Saji H, Matsuda F, Mimori T.
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Journal Title
Rheumatology (Oxford) 49(12)
Pages: 2298-2304
Related Report
Peer Reviewed
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[Journal Article] Anti-U1 RNP antibodies in cerebrospinal fluid are associated with central neuropsychiatric manifestations in systemic lupus erythematosus and mixed connective tissue disease.2010
Author(s)
Sato T, Fujii T, Yokoyama T, Fujita Y, Imura Y, Yukawa N, Kawabata D, Nojima T, Ohmura K, Usui T, Mimori T.
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Journal Title
Arthritis Rheum. 62(12)
Pages: 3730-3740
NAID
Related Report
Peer Reviewed
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[Journal Article] The RIG-I-like receptor IFIH1/MDA5 is a dermatomyositis-specific autoantigen identified by the anti-CADM-140 antibody.2010
Author(s)
Nakashima R, Imura Y, Kobayashi S, Yukawa N, Yoshifuji H, Nojima T, Kawabata D, Ohmura K, Usui T, Fujii T, Okawa K, Mimori T.
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Journal Title
Rheumatology (Oxford) 49(3)
Pages: 433-340
Related Report
Peer Reviewed
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[Journal Article] Gamma/delta T cells are the predominant source of interleukin-17 in affected joints in collagen-induced arthritis, but not in rheumatoid arthritis.2009
Author(s)
Ito Y, Usui T, Kobayashi S, Iguchi-Hashimoto M, Ito H, Yoshitomi H, Nakamura T, Shimizu M, Kawabata D, Yukawa N, Hashimoto M, Sakaguchi N, Sakaguchi S, Yoshifuji H, Nojima T, Ohmura K, Fujii T, Mimori T.
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Journal Title
Arthritis Rheum. 60(8)
Pages: 2294-2303
Related Report
Peer Reviewed
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