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Function analysis of autoantigens in human mature osteoclast from rheumatoid arthritis patient under anti-rheumatic drugs.

Research Project

Project/Area Number 21790946
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeSingle-year Grants
Research Field 膠原病・アレルギー・感染症内科学
Research InstitutionKyoto University

Principal Investigator

NOJIMA Takaki  Kyoto University, 医学研究科, 助教 (30327514)

Project Period (FY) 2009 – 2010
Project Status Completed (Fiscal Year 2010)
Budget Amount *help
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2010: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2009: ¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000)
Keywords破骨細胞 / 自己抗原 / 関節リウマチ
Research Abstract

In osteoclastgenesis system using human peripheral-blood mononuclear cells, we found that calpastatin was cut off and calpain revitalization was elevated from 3 day to 6 day. The protein level changes of calpain 1 and calpain 2 were not detected in our osteoclastgenesis system. Cell permeable calpastatin down-regulated the osteoclastgenesis and the bone absorptivity of human osteoclast. After 15 minutes TNFα (100ng/ml) stimulation, calpain revitalization elevated in human osteoclast.

Report

(3 results)
  • 2010 Annual Research Report   Final Research Report ( PDF )
  • 2009 Annual Research Report
  • Research Products

    (27 results)

All 2011 2010 2009

All Journal Article (23 results) (of which Peer Reviewed: 14 results) Presentation (2 results) Book (2 results)

  • [Journal Article] タクロリムス(ループス腎炎以外のSLE、多発性筋炎/皮膚筋炎、血管炎症候群、成人スティル病など)2011

    • Author(s)
      野島崇樹
    • Journal Title

      リウマチ科 第45巻第1号

      Pages: 25-28

    • Related Report
      2010 Final Research Report
  • [Journal Article] タクロリムス(ループス腎炎以外のSLE、多発性筋炎/皮膚筋炎、血管炎症候群、成人スティル病など)2011

    • Author(s)
      野島崇樹
    • Journal Title

      リウマチ科

      Volume: 45(1) Pages: 25-28

    • Related Report
      2010 Annual Research Report
  • [Journal Article] Anti-citrullinated peptide antibody-negative RA is a genetically distinct subset : a definitive study using only bone-erosive ACPA-negative rheumatoid arthritis.2010

    • Author(s)
      Ohmura K, Terao C, Maruya E, Katayama M, Matoba K, Shimada K, Murasawa A, Honjo S, Takasugi K, Tohma S, Matsuo K, Tajima K, Yukawa N, Kawabata D, Nojima T, Fujii T, Yamada R, Saji H, Matsuda F, Mimori T.
    • Journal Title

      Rheumatology (Oxford) 49(12)

      Pages: 2298-2304

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Anti-U1 RNP antibodies in cerebrospinal fluid are associated with central neuropsychiatric manifestations in systemic lupus erythematosus and mixed connective tissue disease.2010

    • Author(s)
      Sato T, Fujii T, Yokoyama T, Fujita Y, Imura Y, Yukawa N, Kawabata D, Nojima T, Ohmura K, Usui T, Mimori T.
    • Journal Title

      Arthritis Rheum. 62(12)

      Pages: 3730-3740

    • NAID

      120005593598

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Two cases of late-onset drug-induced lupus erythematosus caused by ticlopidine in elderly men.2010

    • Author(s)
      Yokoyama T, Usui T, Kiyama K, Nakashima R, Yukawa N, Kawabata D, Nojima T, Ohmura K, Fujii T, Mimori T.
    • Journal Title

      Mod Rheumatol. 20(4)

      Pages: 405-409

    • NAID

      10026691598

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Periodic fever and erythema nodosum associated with MDS with trisomy 8 : report of two cases and review of the literature.2010

    • Author(s)
      Fujimura T, Yukawa N, Nakashima R, Imura Y, Kawabata D, Nojima T, Ohmura K, Fujii T, Usui T, Mimori T.
    • Journal Title

      Mod Rheumatol. 20(4)

      Pages: 413-419

    • NAID

      10026691630

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Discontinuation of infliximab after attaining low disease activity in patients with rheumatoid arthritis : RRR (remission induction by Remicade in RA) study. RRR study investigators.2010

    • Author(s)
      Tanaka Y, Takeuchi T, Mimori T, Saito K, Nawata M, Kameda H, Nojima T, Miyasaka N, Koike T
    • Journal Title

      Ann Rheum Dis. 69(7)

      Pages: 1286-1291

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Etanercept-induced anti-Jo-1-antibody-positive polymyositis in a patient with rheumatoid arthritis : a case report and review of the literature.2010

    • Author(s)
      石川優樹, Yukawa N, Ohmura K, Hosono Y, Imura Y, Kawabata D, Nojima T, Fujii T, Usui T, Mimori T.
    • Journal Title

      Clin Rheumatol. 29(5)

      Pages: 563-566

    • NAID

      120002191883

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] The RIG-I-like receptor IFIH1/MDA5 is a dermatomyositis-specific autoantigen identified by the anti-CADM-140 antibody.2010

    • Author(s)
      Nakashima R, Imura Y, Kobayashi S, Yukawa N, Yoshifuji H, Nojima T, Kawabata D, Ohmura K, Usui T, Fujii T, Okawa K, Mimori T.
    • Journal Title

      Rheumatology (Oxford) 49(3)

      Pages: 433-340

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] 関節炎におけるinterleukin-1 receptor-associated kinase-4の役割(解説)2010

    • Author(s)
      石川優樹, 野島崇樹
    • Journal Title

      リウマチ科 44巻1号

      Pages: 69-74

    • Related Report
      2010 Final Research Report
  • [Journal Article] 【関節リウマチ(第2版)寛解を目指す治療の新時代】関節リウマチの検査・診断免疫・血清学的検査細胞性免疫検査(解説/特集)2010

    • Author(s)
      野島崇樹
    • Journal Title

      日本臨床 68巻増刊号5関節リウマチ

      Pages: 258-261

    • Related Report
      2010 Final Research Report
  • [Journal Article] ミニレクチャー:関節リウマチでのメトトレキサートの使い方2010

    • Author(s)
      野島崇樹
    • Journal Title

      臨床研修プラクティス 7巻3号

      Pages: 73-74

    • Related Report
      2010 Final Research Report
  • [Journal Article] Anti-citrullinated peptide antibody-negative RA is a genetically distinct subset : a definitive study using only bone-erosive ACPA-negative rheumatoid arthritis.2010

    • Author(s)
      Ohmura K, Terao C, Nojima T, et al
    • Journal Title

      Rheumatology (Oxford)

      Volume: 49(12) Pages: 2298-2304

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Anti-U1 RNP antibodies in cerebrospinal fluid are associated with central neuropsychiatric manifestations in systemic lupus erythematosus and mixed connective tissue disease.2010

    • Author(s)
      Sato T, Fujii T, Nojima T, et al
    • Journal Title

      Arthritis Rheum

      Volume: 62(12) Pages: 3730-3740

    • NAID

      120005593598

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Discontinuation of infliximab after attaining low disease activity in patients with rheumatoid arthritis : RRR (remission induction by Remicade in RA) study2010

    • Author(s)
      Tanaka Y, Takeuchi T, Nojima T, et al
    • Journal Title

      Ann Rheum Dis

      Volume: 69(7) Pages: 1286-1291

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Etanercept-induced anti-Jo-1-antibody-positive polymyositis in a patient with rheumatoid arthritis : a case report and review of the literature.2010

    • Author(s)
      Ishikawa Y, Yukawa N, Nojima T, et al
    • Journal Title

      Clin Rheumatol

      Volume: 29(5) Pages: 563-566

    • NAID

      120002191883

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] The RIG-I-like receptor IFIH1/MDA5 is a dermatomyositis-specific autoantigen identified by the anti-CADM-140 antibody.2010

    • Author(s)
      Nakashima R, Imura Y, Nojima T, et al
    • Journal Title

      Rheumatology (Oxford) 49(3)

      Pages: 433-440

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Gamma/delta T cells are the predominant source of interleukin-17 in affected joints in collagen-induced arthritis, but not in rheumatoid arthritis.2009

    • Author(s)
      Ito Y, Usui T, Kobayashi S, Iguchi-Hashimoto M, Ito H, Yoshitomi H, Nakamura T, Shimizu M, Kawabata D, Yukawa N, Hashimoto M, Sakaguchi N, Sakaguchi S, Yoshifuji H, Nojima T, Ohmura K, Fujii T, Mimori T.
    • Journal Title

      Arthritis Rheum. 60(8)

      Pages: 2294-2303

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] マクロファージにおけるAMP-activated protein kinaseの抗炎症作用2009

    • Author(s)
      野島崇樹
    • Journal Title

      リウマチ科 第42巻第4号

      Pages: 424-428

    • Related Report
      2010 Final Research Report
  • [Journal Article] 早期診断と鑑別診断の留意点2009

    • Author(s)
      野島崇樹
    • Journal Title

      リウマチ科 第41巻第6号

      Pages: 553-557

    • Related Report
      2010 Final Research Report
  • [Journal Article] 早期診断と鑑別診断の留意点2009

    • Author(s)
      野島崇樹
    • Journal Title

      リウマチ科 41(6)

      Pages: 553-557

    • Related Report
      2009 Annual Research Report
  • [Journal Article]2009

    • Author(s)
      野島崇樹
    • Journal Title

      リウマチ科 42(4)

      Pages: 424-428

    • Related Report
      2009 Annual Research Report
  • [Journal Article] Gamma/delta T cells are the predominant source of interleukin-17 in affected joints in collagen-induced arthritis, but not in rheumatoid arthritis.2009

    • Author(s)
      Ito Y, Usui T, Nojima T, et al
    • Journal Title

      Arthritis Rheum. 60(8)

      Pages: 2294-2303

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Presentation] 内科的治療の変遷-生物学的製剤を中心に-2009

    • Author(s)
      野島崇樹
    • Organizer
      第36回日本股関節学会学術集会
    • Place of Presentation
      国立京都国際会館(京都府)
    • Year and Date
      2009-10-30
    • Related Report
      2010 Final Research Report
  • [Presentation] 内科的治療の変遷-生物学的製剤を中心に-2009

    • Author(s)
      野島崇樹
    • Organizer
      第36回 日本股関節学会学術集会
    • Place of Presentation
      国立京都国際会館(京都府)
    • Year and Date
      2009-10-30
    • Related Report
      2009 Annual Research Report
  • [Book] 研修医のための膠原病診療ガイド(関節リウマチでのメトトレキサートの使い方(解説/特集))(7巻3号)2010

    • Author(s)
      野島崇樹
    • Publisher
      臨床研修プラクティス
    • Related Report
      2010 Final Research Report
  • [Book] リウマトイド因子と抗核抗体(リウマチ・膠原病内科クリニカルスタンダード必携ベッドサイドで必ず役立つリウマチ・膠原病学のエッセンス)2010

    • Author(s)
      石川優樹, 野島崇樹
    • Publisher
      文光堂
    • Related Report
      2010 Final Research Report

URL: 

Published: 2009-04-01   Modified: 2016-04-21  

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