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T cells derived from donor bone marrow cells selectively regulate auto-reactive B cells in bone marrow mixed chimeric mice

Research Project

Project/Area Number 21790950
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeSingle-year Grants
Research Field 膠原病・アレルギー・感染症内科学
Research InstitutionKitasato University

Principal Investigator

TAKEUCHI Emiko  北里大学, 医学部, 助教 (00406935)

Project Period (FY) 2009 – 2011
Project Status Completed (Fiscal Year 2011)
Budget Amount *help
¥2,990,000 (Direct Cost: ¥2,300,000、Indirect Cost: ¥690,000)
Fiscal Year 2011: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2010: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2009: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Keywords臨床免疫学 / 骨髄移植 / 骨髄混合キメラ / MHC拘束 / Fas/FasL / アポトーシス / 自己反応性細胞
Research Abstract

Induction of allogeneic bone marrow mixed chimerism through bone marrow transplantation has been proposed as a therapy for patient with severe systemic lupus erythematosus. Yet, the mechanism through which mixed chimerism suppresses the development of autoimmune state is still unknown. Reporting on one possible candidate mechanism, we indicated that newly developed donor T cells that are restricted host MHC and incapable of interactions with donor MHC expressed on donor B cells could selectively regulate and/or trim auto-reactive B cells.

Report

(4 results)
  • 2011 Annual Research Report   Final Research Report ( PDF )
  • 2010 Annual Research Report
  • 2009 Annual Research Report
  • Research Products

    (16 results)

All 2012 2011 2010 2009

All Journal Article (7 results) (of which Peer Reviewed: 4 results) Presentation (7 results) Book (2 results)

  • [Journal Article] Dysfunction of selective suppression of auto-antibody production in SLE mouse and reconstruction of this mechanism by induction of bone marrow chimerism2012

    • Author(s)
      Takeuchi E, Takeuchi Y
    • Journal Title

      J of Transplantation Technologies & Research special issue

      Volume: 5(In press)

    • Related Report
      2011 Final Research Report
  • [Journal Article] Dysfunction of selective suppression of auto-antibody production in SLE mouse and reconstruction of this mechanism by induction of bone-marrow chimerism2012

    • Author(s)
      Takeuchi E, Takeuchi Y
    • Journal Title

      J of Transplantation Technology and Research

      Volume: (in the press)

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Cognate interaction plays a key role in the surveillance of autoreactive B cells in induced mixed bone marrow chimerism in BXSB lupus mice2011

    • Author(s)
      Takeuchi E, Shinohara N, Takeuchi Y
    • Journal Title

      Autoimmunity

      Volume: 44(5) Pages: 363-372

    • Related Report
      2011 Annual Research Report 2011 Final Research Report
  • [Journal Article] Allogenic mixed chimerism prevented autoimmune thrombocytopenia in BXSB lupus mice receiving donor BMT with nonlymphoablative conditioning of low-dose TBI and anti CD40L mAb2011

    • Author(s)
      Takeuchi E
    • Journal Title

      Kitasato Med J

      Volume: 41(1) Pages: 50-56

    • NAID

      40018724980

    • Related Report
      2011 Final Research Report
  • [Journal Article] Allogenic mixed chimerism prevented autoimmune thrombocytopenia in BXSB lupus mice receiving donor BMT with nonlyniphoablative conditioning of low-dose TBI and anti CD40L mAb2011

    • Author(s)
      Takeuchi E
    • Journal Title

      Kitasato Med.J.

      Volume: 41(1) Pages: 50-56

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Cognate interaction plays a key role in the surveillance of autoreactive B cells in induced mixed bone marrow chimerism in BXSB lupus mice.2011

    • Author(s)
      Takeuchi E, Shinohara N, et al
    • Journal Title

      Autoimmunity

      Volume: (in press)

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Allogenic mixed chimerism prevented autoimmune thrombocytopenia in BXSB lupus mice receiving donor BMT with nonlymphoablative conditioning of low-dose TBI and anti CD40L mAb.2011

    • Author(s)
      Takeuchi E
    • Journal Title

      Kitasato Med.J.

      Volume: 41(in press)

    • NAID

      40018724980

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Presentation] Dysfunction of selective suppression of auto-antibody production in SLE mice and reconstruction of this mechanism by induction of bone-marrow chimerism2011

    • Author(s)
      Takeuchi E, Katagiri H, Eshima K, Shinohara N, Takeuchi Y
    • Organizer
      1st Controversies in Rheumatorogy and Autoimmunity
    • Place of Presentation
      Italy
    • Related Report
      2011 Final Research Report
  • [Presentation] Dysfunction of selective suppression of auto-antibody production in SLE mice and reconstruction of this mechanism by induction of bone-marrow chimerism.2011

    • Author(s)
      Takeuchi E, Katagiri H, et al
    • Organizer
      1st Controversies in Rheumatorogy and Autoimmunity
    • Place of Presentation
      Firence, Italy
    • Related Report
      2010 Annual Research Report
  • [Presentation] MHC完全不一致ドナーからの骨髄移植による自己免疫性血小板減少症の改善についての検討2010

    • Author(s)
      Takeuchi E, Kanoh Y
    • Organizer
      第57回日本臨床検査医学会学術集会
    • Place of Presentation
      Sinnjyuku, Japan
    • Related Report
      2011 Final Research Report
  • [Presentation] Dysfunction of selective suppression of auto-antibody production in SLE mouse and reconstruction of this mechanism by induction of bone-marrow chimerism2010

    • Author(s)
      Takeuchi E, Kobayashi K, Katagiri H, Eshima K, Shinohara N, Takeuchi Y
    • Organizer
      7th International congress on autoimmunity
    • Place of Presentation
      Ljubljana, Slovenia
    • Related Report
      2011 Final Research Report
  • [Presentation] Dysfunction of selective suppression of auto-antibody production in SLE mouse and reconstruction of this mechanism by induction of bone-marrow chimerism.2010

    • Author(s)
      Takeuchi E, Kobayashi K., et al
    • Organizer
      7th International Congress on Autoimmunity
    • Place of Presentation
      Ljubljana, Slovenia
    • Related Report
      2010 Annual Research Report
  • [Presentation] MHC完全不一致ドナーからの骨髄移植による自己免疫性血小板減少症の改善についての検討2010

    • Author(s)
      Takeuchi E, Kanho Y
    • Organizer
      第57回日本臨床検査医学会学術集会
    • Place of Presentation
      京王プラザホテル(東京都)
    • Related Report
      2010 Annual Research Report
  • [Presentation] A threshold in expression levels of gp91phox transgene limits the degree of functional correction in granulocytes after gene therapy for CGD2009

    • Author(s)
      Takeuchi Y, Otsu M, Onodera M, Takeuchi E, Nakauchi H
    • Organizer
      17th Annual congress of the European society of gene & cell therapy
    • Place of Presentation
      Hannover, Gernany
    • Related Report
      2011 Final Research Report
  • [Book] An Update Glomerulopathies2011

    • Author(s)
      Takeuchi E
    • Publisher
      INTECK
    • Related Report
      2011 Final Research Report
  • [Book] An up date Glomerulopathies Clinical and Treatment Aspects (うちchaptor 16)2011

    • Author(s)
      Sharma S.Prabhakar
    • Publisher
      INTECH
    • Related Report
      2011 Annual Research Report

URL: 

Published: 2009-04-01   Modified: 2016-04-21  

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