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Development of biomarkers for the elucidation of pathophysiology and early diagnosis of chronic allograft nephropathy

Research Project

Project/Area Number 21790971
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeSingle-year Grants
Research Field Pediatrics
Research InstitutionNiigata University

Principal Investigator

SUZUKI Toshiaki  新潟大学, 医歯学総合病院, 助教 (50419305)

Project Period (FY) 2009 – 2011
Project Status Completed (Fiscal Year 2011)
Budget Amount *help
¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2011: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2010: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2009: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Keywords慢性移植腎症 / マクロファージ / CD163抗原 / 間質線維化
Research Abstract

Chronic allograft nephropathy(CAN) is the major cause of failure of renal graft function. It has posed diagnostic challenge and there have been no non-invasive diagnostic procedures of CAN that is also safe for pediatric patients.
We have previously reported that activated macrophages(Mφ) play a major role in renal tissue impairment and fibrosis and shown that CD163-positive Mφ, one of Mφsubtypes, may be involved in the formation of chronic lesions.
In this study, we measured urinary CD163 antigen levels and investigated their correlation with histological and clinical findings. In renal biopsy specimens, the number of interstitial CD163-positive Mφwas positively correlated with severity of fibrosis. The urinary CD163 levels were also correlated with renal graft function in the stable phase after the acute phase and may indicate the degree of progression of renal graft fibrosis.
These results suggest that CD163-positive Mφis deeply involved in the progression of CAN and the urinary CD163 can be used as a non-invasive marker for the early diagnosis of CAN.

Report

(4 results)
  • 2011 Annual Research Report   Final Research Report ( PDF )
  • 2010 Annual Research Report
  • 2009 Annual Research Report
  • Research Products

    (15 results)

All 2012 2011 2010 2009

All Journal Article (11 results) (of which Peer Reviewed: 5 results) Presentation (4 results)

  • [Journal Article] Nonadherenceを原因とする拒絶反応から、移植腎機能低下をきたした13歳男児例思春期における腎移植後患児のNonadherenceについて2012

    • Author(s)
      鈴木俊明, 池住洋平, 唐澤環, 長谷川博也, 内山聖, 中川由希, 斎藤和英, 高橋公太, 石原俊二, 原正則, 柳原俊雄
    • Journal Title

      日本小児腎臓病学会雑誌

      Volume: 25 Pages: 58-62

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Nonadherenceを原因とする拒絶反応から移植腎機能低下をきたした13歳男児-思春期における腎移植後患児のNonadherenceについて-2012

    • Author(s)
      鈴木俊明
    • Journal Title

      日本小児腎臓病学会雑誌

      Volume: Vol.25 No.1 Pages: 58-62

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Identification of alternatively activated macrophages in new-onset paediatric and adult immunoglobulin A nephropathy : potential role in mesangial matrix expansion2011

    • Author(s)
      Ikezumi Y, Suzuki T, Karasawa T, Hasegawa H, Yamada T, Imai N, Narita I, Kawachi H, Polkinghorne KR, Nikolic-Paterson DJ, Uchiyama M
    • Journal Title

      Histopathology

      Volume: 58 Pages: 198-210

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] 治療反応性および経過が全く異なる、Diffuse Mesangial Sclerosisの3例2011

    • Author(s)
      鈴木俊明, 池住洋平, 唐澤環, 長谷川博也, 高橋雄一, 山田剛史, 内山聖
    • Journal Title

      日本小児腎不全学会雑誌

      Volume: 31 Pages: 169-171

    • Related Report
      2011 Final Research Report
  • [Journal Article] 治療反応性および経過が全く異なるDiffuse Mesangial Sclerosisの3例2011

    • Author(s)
      鈴木俊明
    • Journal Title

      日本小児腎不全学会雑誌

      Volume: Vol.31 Pages: 169-171

    • Related Report
      2011 Annual Research Report
  • [Journal Article] Contrasting effects of steroids and mizoribine on macrophage activation and glomerular lesions in rat thy-1 mesangial proliferative glomerulo-nephritis2010

    • Author(s)
      Ikezumi Y, Suzuki T, Karasawa T, Hasegawa H, Kawachi H, Nikolic-Paterson DJ, Uchiyama M
    • Journal Title

      Am J Nephrol

      Volume: 31 Pages: 273-82

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] 慢性糸球体腎炎における活性化マクロファージ2010

    • Author(s)
      池住洋平, 鈴木俊明, 唐澤環, 長谷川博也, 内山聖
    • Journal Title

      日本小児腎臓病学会雑誌

      Volume: 23 Pages: 134-140

    • NAID

      130000814253

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] 慢性移植腎症の成因におけるM2マクロファージの関与2010

    • Author(s)
      池住洋平, 鈴木俊明, 唐澤環, 山田剛史, 長谷川博也, 内山聖, 原正則, 柳原俊雄
    • Journal Title

      日本小児腎不全学会雑誌

      Volume: 30 Pages: 296-298

    • NAID

      10027698105

    • Related Report
      2011 Final Research Report
  • [Journal Article] 知的障害児における腎移植前後の変化2010

    • Author(s)
      鈴木俊明、池住洋平
    • Journal Title

      今日の移植

      Volume: 23 Pages: 231-233

    • Related Report
      2011 Final Research Report
  • [Journal Article] 下大静脈閉塞を有する女児に対し、小児ドナーの二次献腎移植を行った1例2010

    • Author(s)
      鈴木俊明, 池住洋平, 唐澤環, 山田剛史, 長谷川博也, 内山聖, 中川由紀, 斎藤和英, 高橋公太
    • Journal Title

      日本小児腎不全学会雑誌

      Volume: 30 Pages: 142-144

    • NAID

      10027697720

    • Related Report
      2011 Final Research Report
  • [Journal Article] 慢性移植腎症の成因におけるM2マクロファージの関与2010

    • Author(s)
      池住洋平、鈴木俊明, 他
    • Journal Title

      日児腎不全誌

      Volume: 30 Pages: 296-298

    • NAID

      10027698105

    • Related Report
      2010 Annual Research Report
  • [Presentation] 慢性移植腎症の進展マーカーとしての尿中CD163測定2011

    • Author(s)
      鈴木俊明
    • Organizer
      日本小児腎不全学会
    • Place of Presentation
      焼津市
    • Year and Date
      2011-10-20
    • Related Report
      2011 Final Research Report
  • [Presentation] 慢性移植腎症の進展マーカーとしての尿中CD163測定2011

    • Author(s)
      鈴木俊明
    • Organizer
      日本小児腎不全学会
    • Place of Presentation
      静岡県焼津市
    • Year and Date
      2011-10-20
    • Related Report
      2011 Annual Research Report
  • [Presentation] Corticosteroid augments cyclosporine nephrotoxicity in childhood nephrotic syndrome via alternative activation of macrophage.2010

    • Author(s)
      鈴木俊明、長谷川博也, 他
    • Organizer
      43rd Annual Meeting of American Society of Nephrology.
    • Place of Presentation
      Denver, Colorado, USA
    • Year and Date
      2010-11-19
    • Related Report
      2010 Annual Research Report
  • [Presentation] 慢性移植腎症の成因におけるM2マクロファージの関与2009

    • Author(s)
      鈴木俊明、池住洋平, 他
    • Organizer
      第31回 日本小児腎不全学会
    • Place of Presentation
      新潟県
    • Year and Date
      2009-10-09
    • Related Report
      2009 Annual Research Report

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Published: 2009-04-01   Modified: 2016-04-21  

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