Structural studies on IL-18 ligand receptor complex for designing new drugs of allergy and autoimmune diseases

Research Project

Project/Area Number	21790979
Research Category	Grant-in-Aid for Young Scientists (B)
Allocation Type	Single-year Grants
Research Field	Pediatrics
Research Institution	Gifu University
Principal Investigator	KIMURA Takeshi 岐阜大学, 医学部・附属病院, 助教 (60422705)
Project Period (FY)	2009 – 2011
Project Status	Completed (Fiscal Year 2011)
Budget Amount *help	¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000) Fiscal Year 2011: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000) Fiscal Year 2010: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000) Fiscal Year 2009: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
Keywords	IL-18 / 構造解析 / 複合体 / 結晶構造解析 / Interleukin-18 / X線結晶構造解析 / レセプター複合体
Research Abstract	Inter leukin-18(IL-18), found as interferon-γinducing factor, plays a critical role in innate and acquired immune response against microbes. IL-18 would also contribute to the pathogenesis of inflammatory diseases. To elucidate the pathogenesis and structure of IL-18 I igand-receptor complex, we have expressed recombinant IL-18Rαand IL-18Rβwith baculo-Insect cell systems and crystallized it as IL-18/IL18Rα/IL-18Rβheterotr imer ic complex and obtained X-ray diffraction data from the crystal.

Report

(4 results)