Therapeutic Effect of Hydrogen on Monocrotaline-induced Pulmonary Hypertension in Rat.

• Project/Area Number: 21790981
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Single-year Grants
• Research Field: Pediatrics
• Research Institution: Nagoya University
• Principal Investigator: KATO Taichi Nagoya University, 医学部附属病院, 助教 (20422777)
• Project Period (FY): 2009 – 2010
• Project Status: Completed (Fiscal Year 2010)
• Budget Amount: ¥3,120,000 (Direct Cost: ¥2,400,000、Indirect Cost: ¥720,000); Fiscal Year 2010: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000); Fiscal Year 2009: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
• Keywords: 肺高血圧 / 酸化ストレス / 炎症

Research Abstract

The effect of hydrogen on monocrotaline-induced pulmonary hypertension in rat was evaluated. Hydrogen improved systolic right ventricular pressure and musucularization of pulmonary vasculature. Furthermore, in monocrotaline-induced pulmonary hypertension rat, the numbers of perivascular macrophages, fibroblasts, 8OhdG-positive cells and Ki-67-positive cells were increased, which were suppressed by hydrogen. These results suggest hydrogen ameliorates monocrotaline-induced pulmonary hypertension in rat via anti-inflammatory, anti-oxidative stress and anti-proliferative effect.

Research Products

• [Journal Article] Coronary arterial ectasia in a 2-year-old boy showing two symptoms of Kawasaki disease without manifesting fever. (2011)
  • Author(s): Kato T, Numaguchi A, Ando H, Yasui M,Kishimoto Y, Yasuda K, Fukumi D, Yasuda T.
  • Journal Title: Rheumatology International. in press
  • Peer Reviewed
• [Journal Article] Coronary arterial ectasia in a 2-year-old boy showing two symptoms of Kawasaki disease without manifesting fever. (2011)
  • Author(s): 加藤太一
  • Journal Title: Rheumatology International Volume: (印刷中 未定)
  • Peer Reviewed
• [Journal Article] Elevated levels of aldosterone in the amniotic fluid in two cases of congenital mesoblastic nephroma. (2010)
  • Author(s): Kotani T, Sumigama S, Hayakawa H, Mano Y, Tsuda H, Sugiyama C, Kawachi F, Hironaka M, Kato T, Kaneko K, Hayakawa M, Kikkawa F.
  • Journal Title: Ultrasound Obstet Gynecol 36 Pages: 256-258
  • Peer Reviewed
• [Journal Article] Elevated levels of aldosterone in the amniotic fluid in two cases of congenital mesoblastic nephroma. (2010)
  • Author(s): 小谷友美、加藤太一, ら
  • Journal Title: Ultrasound Obstet Gynecol Volume: 36 Pages: 256-258
  • Peer Reviewed
• [Presentation] 胎児拡張型心筋症から母体抗SS-A抗体陽性と判明した症例 (2011)
  • Author(s): 西川浩、今井祐喜、吉田修一朗、久保田勤也、松島正氣、大橋直樹、斉藤調子、加藤太一
  • Organizer: 第17回日本胎児心臓病学会学術集会
  • Place of Presentation: 旭川
  • Year and Date: 2011-02-18
• [Presentation] Contribution of bone marrow stem cells to the pathogenesis of pulmonary hypertension and pharmacological modulation of bone marrow-derived cells as a therapeutic target (2010)
  • Author(s): 加藤太一
  • Organizer: The 3^<rd> Congress of Asia-Pacific Pediatric Cazdiac Society
  • Place of Presentation: シェラトングランデトーキョーベイホテル(千葉県)
  • Year and Date: 2010-07-06
• [Presentation] Contribution of bone marrow stem cells to the pathogenesis of pulmonary hypertension and pharmacological modulation of bone marrow-derived cells as a therapeutic target. (2010)
  • Author(s): Kato T, Sawada H, Maruyama J, Masuya M, Miyata E, Nakamura S, Ikeyama Y, Shimpo H, Maruyama K, Komada Y, Mitani Y.
  • Organizer: The 3^<rd> Congress of Asia-Pacific Pediatric Cardiac Society.
  • Place of Presentation: Chiba, Japan.
  • Year and Date: 2010-06-06
• [Presentation] Bosentan promotes incorporation of bone marrow-derived endothelial cells but inhibits infiltration of macrophages into pulmonary vascular lesions in mice exposed to chronic hypoxia : A novel concept of bosentan therapy in pulmonary hypertension (2009)
  • Author(s): Kato T, Sawada H, Maruyama J, Deguchi T, Ikeyama Y, Masuya M, Miyata E, Nakamura S,, Shimpo H, Maruyama K, Komada Y, Mitani Y.
  • Organizer: American Heart Association Scientific Sessions 2009.
  • Place of Presentation: Orlando, USA
  • Year and Date: 2009-11-17
• [Presentation] マウス肺高血圧発症における骨髄由来幹細胞の役割とボセンタンによる制御-肺高血圧に対する内科的再生医療の可能性- (2009)
  • Author(s): 加藤太一, 三谷義英, 澤田博文, 池山夕起子, 出口隆生, 桝屋正浩, 宮田恵里, 丸山淳子, 丸山一男, 新保秀人, 駒田美弘
  • Organizer: 第45回日本小児循環器学会
  • Place of Presentation: 神戸
  • Year and Date: 2009-07-17
• [Presentation] マウス肺高血圧発症における骨髄由来幹細胞の役割とボセンタンによる制御-肺高血圧に対する内科的再生医療の可能性 (2009)
  • Author(s): 加藤太一
  • Organizer: 第45回日本小児循環器学会総会
  • Place of Presentation: 神戸
  • Year and Date: 2009-07-17
• [Presentation] Role of bone marrow stem cells in the pathogenesis of pulmonary hypertension and pharmacological modulation (2009)
  • Author(s): Kato T, Mitani Y, Komada K, Ito M
  • Organizer: 10^<th> International Symposium on Mechanisms of Vasodilatation
  • Place of Presentation: Matsushima
  • Year and Date: 2009-06-01