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Association between innate immunity and pathophysiology of Kawasaki disease

Research Project

Project/Area Number 21790993
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeSingle-year Grants
Research Field Pediatrics
Research InstitutionKyushu University

Principal Investigator

池田 和幸  Kyushu University, 医学研究院・成長発達医学分野, 九州大学病院小児科講師 (30507786)

Project Period (FY) 2009 – 2010
Project Status Completed (Fiscal Year 2010)
Budget Amount *help
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2010: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2009: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
Keywords川崎病 / 自然免疫
Research Abstract

Both microarray and quantitative RT-PCR analyses have shown that the innate immune system might be involved in the pathogenesis and pathophysiology of Kawasaki disease. NOD Ligands enhance ICAM-1 expression and cytokine production by human coronary artery endothelial cells in vitro.

Report

(3 results)
  • 2010 Annual Research Report   Final Research Report ( PDF )
  • 2009 Annual Research Report
  • Research Products

    (13 results)

All 2010 2009 Other

All Journal Article (5 results) (of which Peer Reviewed: 2 results) Presentation (8 results)

  • [Journal Article] Unique activation status of peripheral blood mononuclear cells at acute phase of Kawasaki disease.2010

    • Author(s)
      Ikeda K, Yamaguchi K, Tanaka T, Mizuno Y, Hijikata A, Ohara O, Takada H, Kusuhara K, Hara T
    • Journal Title

      Clin Exp Immunol 160

      Pages: 246-55

    • Related Report
      2010 Final Research Report
  • [Journal Article] Incomplete Kawasaki disease in a patient with chronic granulomatous disease.2010

    • Author(s)
      Muneuchi J, Ishimura M, Takada H, Hoshina T, Utsunomiya R, Ikeda K, Yamaguchi K, Ohga S, Kusuhara K, Hara T
    • Journal Title

      Pediatr Int 52

      Pages: 134-136

    • Related Report
      2010 Final Research Report
  • [Journal Article] A novel SCN5A mutation associated with the linker between III and IV domains of Na(v)1.5 in a neonate with fatal long QT syndrome.2010

    • Author(s)
      Yamamura K, Muneuchi J, Uike K, Ikeda K, Inoue H, Takahata Y, Shiokawa Y, Yoshikane Y, Makiyama T, Horie M, Hara T
    • Journal Title

      Int J Cardiol 145

      Pages: 61-64

    • Related Report
      2010 Final Research Report
  • [Journal Article] Unique activation status of peripheral blood mononuclear cells at a cute phase of Kawasaki disease.2010

    • Author(s)
      Kazuyuki Ikeda
    • Journal Title

      Clin Exp Immunol

      Volume: 160 Pages: 246-55

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Unique activation status of peripheral blood mononuclear cells at acute phase of kawasaki disease.

    • Author(s)
      Kazuyuki Ikeda
    • Journal Title

      Clin Exp Immunol (In press)

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Presentation] Unique activation status of peripheral blood mononuclear cells at acute phase of Kawasaki disease.2010

    • Author(s)
      Ikeda K, Yamaguchi K, Tanaka T, Mizuno Y, Hijikata A, Ohara O, Takada H, Kusuhara K, Hara T
    • Organizer
      The Fukuoka International Symposium on Perinatal Medicine (FISPM).
    • Place of Presentation
      Fukuoka, Japan
    • Year and Date
      2010-08-21
    • Related Report
      2010 Final Research Report
  • [Presentation] 原寿郎Host genetic factor と臨床データを組み合わせた新たな冠動脈病変(CAL)予測法の開発2010

    • Author(s)
      池田和幸、山村健一郎、永田弾、松尾知子、水野由美
    • Organizer
      第9回九州川崎病研究会
    • Place of Presentation
      長崎
    • Year and Date
      2010-05-22
    • Related Report
      2010 Final Research Report
  • [Presentation] Unique activation status of peripheral blood mononuclear cells at acute phase of Kawasaki disease.2010

    • Author(s)
      Ikeda K, Yamaguchi K, Tanaka T, Mizuno Y, Hijikata A, Ohara O, Takada H, Kusuhara K, Hara T
    • Organizer
      The 6th Congress of Asian Society of Pediatric Research.
    • Place of Presentation
      Taipei, Taiwan
    • Related Report
      2010 Final Research Report
  • [Presentation] 原寿郎重度細胞性免疫不全症のため動脈管ステント留置術を選択した総動脈管症、大動脈弓離断症の1例2010

    • Author(s)
      池田和幸、山村健一郎、井上普介、宗内淳、永田弾、総崎直樹、角秀秋
    • Organizer
      第21回日本 Pediatric InterventionalCardiology研究会
    • Place of Presentation
      静岡
    • Related Report
      2010 Final Research Report
  • [Presentation] 原寿郎Host genetic factor と臨床データを組み合わせた新たな冠動脈病変(CAL)予測法の開発2010

    • Author(s)
      池田和幸、山村健一郎、永田弾、松尾知子、水野由美
    • Organizer
      第46回日本小児循環器学会総会・学術集会
    • Place of Presentation
      千葉
    • Related Report
      2010 Final Research Report
  • [Presentation] 原寿郎遺伝子多型解析を用いた川崎病発症に関する宿主因子の検討2010

    • Author(s)
      池田和幸、山村健一郎、永田弾、松尾知子、水野由美
    • Organizer
      第30回日本川崎病学会
    • Place of Presentation
      京都
    • Related Report
      2010 Final Research Report
  • [Presentation] Host genetic factorと臨床データを組み合わせた新たな冠動脈病変(CAL)予測法の開発2010

    • Author(s)
      池田和幸, 他
    • Organizer
      第46回日本小児循環器学会総会・学術集会
    • Place of Presentation
      千葉
    • Related Report
      2010 Annual Research Report
  • [Presentation] 川崎病の包括的研究1 急性期病態と自然免疫の関連2009

    • Author(s)
      池田和幸
    • Organizer
      日本小児科学会学術集会
    • Place of Presentation
      奈良
    • Year and Date
      2009-04-18
    • Related Report
      2009 Annual Research Report

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Published: 2009-04-01   Modified: 2016-04-21  

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