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A pilot study aimed at clinical application of anti-tumor effects of eosinophils

Research Project

Project/Area Number 21791017
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeSingle-year Grants
Research Field Pediatrics
Research InstitutionGunma Institute of Public Health and Environmental Sciences

Principal Investigator

YAMADA Yoshiyuki  Gunma Institute of Public Health and Environmental Sciences, 研究員 (80309252)

Project Period (FY) 2009 – 2010
Project Status Completed (Fiscal Year 2010)
Budget Amount *help
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2010: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2009: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
Keywords小児腫瘍学 / 好酸球
Research Abstract

Eosinophils are white blood cells that can attack against tumor cells, which is called "anti-tumor effects of eosinophils". This study was aimed to determine the tumor cells that are easily weakened by eosinophils. In addition, the experiments to establish useful mouse models to check anti-tumor effects of eosinophils have done. This study may give useful information for clinical application of anti-tumor effects of eosinophils.

Report

(3 results)
  • 2010 Annual Research Report   Final Research Report ( PDF )
  • 2009 Annual Research Report
  • Research Products

    (58 results)

All 2011 2010 2009

All Journal Article (28 results) (of which Peer Reviewed: 22 results) Presentation (30 results)

  • [Journal Article] Eosinophilic gastrointestinal disorders in infants : a Japanese case series.2011

    • Author(s)
      Yamada Y, Nishi A, Ebara Y, Kato M, Yamamoto H, Morita H, Nomura I, Matsumoto K, Hirato J, Hatakeyama SI, et al
    • Journal Title

      Int Arch Allergy Immunol 155 Suppl 1

      Pages: 40-45

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Differential effects of corticosteroids on serum eosinophil cationic protein and cytokine production in rhinovirus-and respiratory syncytial virus-induced acute exacerbation of childhood asthma.2011

    • Author(s)
      Kato M, Yamada Y, Maruyama K, Hayashi Y
    • Journal Title

      Int Arch Allergy Immunol 155 Suppl 1

      Pages: 77-84

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] An 8-year-old boy with hypereosinophilic syndrome.2011

    • Author(s)
      Hosoki K, Nagao M, Iguchi K, Ihara T, Yamada Y, Higashigawa M, Kephart GM, Kita H, Fujisawa T
    • Journal Title

      Int Arch Allergy Immunol 155 Suppl 1

      Pages: 117-122

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Different cytokine profile and eosinophil activation are involved in rhinovirus-and RS virus-induced acute exacerbation of childhood wheezing.2011

    • Author(s)
      Kato M, Tsukagoshi H, Yoshizumi M, Saitoh M, Kozawa K, Yamada Y, Maruyama K, Hayashi Y, Kimura H
    • Journal Title

      Pediatr Allergy Immunol 22(1 Pt 2)

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] 専門医のためのアレルギー学講座 好酸球増多を主徴とする疾患 好酸球増多症候群に見られる遺伝子異常と分子標的治療薬2011

    • Author(s)
      山田佳之
    • Journal Title

      アレルギー 60(2)

      Pages: 167-177

    • Related Report
      2010 Final Research Report
  • [Journal Article] Eosinophilic gastrointestinal disorders (EGIDs) in infants-A Japanese case series.2011

    • Author(s)
      Yamada Y, Nishi A, Ebara Y, Kato M, Yamamoto H, Morita H, et al.
    • Journal Title

      Int Arch Allergy Immunol.

      Volume: (in press)

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] An 8-year-old boy with hypereosinophilic syndrome.2011

    • Author(s)
      Hosoki K, Nagao M, Iguchi K, Ihara T, Yamada Y, Higashigawa M, et al.
    • Journal Title

      Int Arch Allergy Immunol.

      Volume: (in press)

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Differential Effects of Corticosteroids on Serum Eosinophil Cationic Protein and Cytokine Production in Rhinovirus- and RS virus-induced Acute Exacerbation of Childhood Asthma.2011

    • Author(s)
      Kato M, Yamada Y, Maruyama K, Hayashi Y.
    • Journal Title

      Int Arch Allergy Immunol.

      Volume: (in press)

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Prominent eosinophilia but less eosinophil activation in a patient with Omenn syndrome.2010

    • Author(s)
      Seki M, Kimura H, Mori A, Shimada A, Yamada Y, Maruyama K, Hayashi Y, Agematsu K, Morio T, Yachie A, et al
    • Journal Title

      Pediatr Int 52(4)

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] FIP1L1/PDGFR alpha-associated systemic mastocytosis.2010

    • Author(s)
      Yamada Y, Cancelas JA
    • Journal Title

      Int Arch Allergy Immunol 152 Suppl 1

      Pages: 101-105

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Serum eosinophil cationic protein and 27 cytokines/chemokines in acute exacerbation of childhood asthma.2010

    • Author(s)
      Kato M, Yamada Y, Maruyama K, Hayashi Y
    • Journal Title

      Int Arch Allergy Immunol 152 Suppl 1

      Pages: 62-66

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] 【注目される好酸球関連疾患】 好酸球性胃腸炎 好酸球性消化管疾患(eosinophilic gastrointestinal disorders ; EGID)について2010

    • Author(s)
      山田佳之
    • Journal Title

      臨床免疫・アレルギー科 54(4)

      Pages: 459-464

    • Related Report
      2010 Final Research Report
  • [Journal Article] 好酸球増多症 好酸球増多症候群での最近の知見2010

    • Author(s)
      山田佳之
    • Journal Title

      日本小児血液学会雑誌 24(2)

      Pages: 77-84

    • NAID

      10026419288

    • Related Report
      2010 Final Research Report
  • [Journal Article] Peripheral lymphocyte subset and serum cytokine profiles of patients with West syndrome.2010

    • Author(s)
      Shiihara T, Miyashita M, Yoshizumi M, Watanabe M, Yamada Y, Kato M
    • Journal Title

      Brain Dev 32(9)

      Pages: 695-702

    • NAID

      10027492486

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] A case of Baraitser-Winter syndrome with unusual brain MRI findings : pachygyria, subcortical-band heterotopia, and periventricular heterotopia.2010

    • Author(s)
      Shiihara T, Maruyama K, Yamada Y, Nishimura A, Matsumoto N, Kato M, Sakazume S
    • Journal Title

      Brain Dev 32(6)

      Pages: 502-505

    • NAID

      10027491832

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Different cytokine profile and eosinophil activation are involved in rhinovirus- and RS virus-induced acute exacerbation of childhood wheezing.2010

    • Author(s)
      Kato M, Tsukagoshi H, Yoshizumi M, Saitoh M, Kozawa K, Yamada Y, et al.
    • Journal Title

      Pediatr Allergy Immunol.

      Volume: Feb;22(1Pt 2)

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] FIP1L1/PDGFR alpha-associated systemic mastocytosis.2010

    • Author(s)
      Yamada Y, Cancelas JA.
    • Journal Title

      Int Arch Allergy Immunol.

      Volume: 152 Suppl1 Pages: 101-105

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Prominent eosinophilia but less eosinophil activation in a patient with Omenn syndrome.2010

    • Author(s)
      Seki M, Kimura H, Mori A, Shimada A, Yamada Y, Maruyama K, et al.
    • Journal Title

      Pediatr Int.

      Volume: Aug;52(4)

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Serum eosinophil cationic protein and 27 cytokines/chemokines in acute exacerbation of childhood asthma.2010

    • Author(s)
      Kato M, Yamada Y, Maruyama K, Hayashi Y.
    • Journal Title

      Int Arch Allergy Immunol.

      Volume: 152 Suppl1 Pages: 62-66

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 好酸球性胃腸炎-好酸球性消化管疾患について-2010

    • Author(s)
      山田佳之
    • Journal Title

      臨床免疫・アレルギー科

      Volume: 54 Pages: 459-464

    • Related Report
      2010 Annual Research Report
  • [Journal Article] 好酸球増多症-好酸球増多症候群での最近の知見2010

    • Author(s)
      山田佳之
    • Journal Title

      日本小児血液学会誌

      Volume: 24 Pages: 77-84

    • NAID

      10026419288

    • Related Report
      2010 Annual Research Report
  • [Journal Article] 好酸球増多症候群に見られる遺伝子異常と分子標的治療薬2010

    • Author(s)
      山田佳之
    • Journal Title

      アレルギー

      Volume: 60(2) Pages: 167-177

    • Related Report
      2010 Annual Research Report
  • [Journal Article] Murine model of hypereosinophilic syndromes/chronic eosinophilic leukemia.2009

    • Author(s)
      Yamada Y, Cancelas JA, Rothenberg ME
    • Journal Title

      Int Arch Allergy Immunol 149 Suppl 1

      Pages: 102-107

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Thioredoxin reduces C-C chemokine-induced chemotaxis of human eosinophils.2009

    • Author(s)
      Kobayashi N, Yamada Y, Ito W, Ueki S, Kayaba H, Nakamura H, Yodoi J, Chihara J
    • Journal Title

      Allergy 64(8)

      Pages: 1130-1135

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Peripheral lymphocyte subset and serum cytokine profiles of patients with West syndrome2009

    • Author(s)
      Shiihara T, Miyashita M, Yoshizumi M, Watanabe M, Yamada Y, Kato M.
    • Journal Title

      Brain Dev. Nov 30(Epub)(Epub ahead of print)

    • NAID

      10027492486

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Murine model of hypereosinophilic syndromes/chronic eosinophilic leukemia2009

    • Author(s)
      Yamada Y, Cancelas JA, Rothenberg ME.
    • Journal Title

      Int Arch Allergy Immunol. 149

      Pages: 102-107

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] A case of Baraitser-Winter syndrome with unusual brain MRI findings : pachygyria, subcortical-band heterotopia, and periventricular heterotopia2009

    • Author(s)
      Shiihara T, Maruyama K, Yamada Y, Nishimura A, Matsumoto N, Kato M, Sakazume S.
    • Journal Title

      Brain Dev. May 23(Epub)(Epub ahead of print)

    • NAID

      10027491832

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Thioredoxin reduces C-C chemokine-induced chemotaxis of human eosinophils.2009

    • Author(s)
      Kobayashi N, Yamada Y, Ito W, Ueki S, Kayaba H, Nakamura H, Yodoi J, Chihara J.
    • Journal Title

      Allergy. 64(8)

      Pages: 1130-5

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Presentation] 高好酸球血症のメカニズム、鑑別診断と好酸球性食道炎の最新知見2011

    • Author(s)
      山田佳之
    • Organizer
      平成22年度第2回新生児-乳児アレルギー疾患研究会
    • Place of Presentation
      東京
    • Year and Date
      2011-02-06
    • Related Report
      2010 Annual Research Report 2010 Final Research Report
  • [Presentation] 後方視的検討で発見された小児好酸球性食道炎2010

    • Author(s)
      山田佳之, 加藤政彦
    • Organizer
      第47回日本小児アレルギー学会
    • Place of Presentation
      横浜
    • Year and Date
      2010-12-05
    • Related Report
      2010 Final Research Report
  • [Presentation] 後方視的検討で発見された小児好酸球性食道炎2010

    • Author(s)
      山田佳之, 加藤政彦
    • Organizer
      第47回日本小児アレルギー学会
    • Place of Presentation
      神奈川
    • Year and Date
      2010-12-05
    • Related Report
      2010 Annual Research Report
  • [Presentation] ライノウイルスおよびRSウイルスによる小児気管支喘息発作時の血清中サイトカイン/ケモカイン産生と好酸球活性化の相違2010

    • Author(s)
      加藤政彦, 山田佳之
    • Organizer
      第47回日本小児アレルギー学会
    • Place of Presentation
      横浜
    • Year and Date
      2010-12-04
    • Related Report
      2010 Final Research Report
  • [Presentation] ライノウイルスおよびRSウイルスによる小児気管支喘息発作時の血清中サイトカイン/ケモカイン産生と好酸球活性化の相違2010

    • Author(s)
      加藤政彦, 山田佳之
    • Organizer
      第47回日本小児アレルギー学会
    • Place of Presentation
      神奈川
    • Year and Date
      2010-12-04
    • Related Report
      2010 Annual Research Report
  • [Presentation] 小児喘息と気道感染ライノおよびRSウイルスによる小児気管支喘息発作時の血清中サイトカイン産生と好酸球活性化の相違について2010

    • Author(s)
      加藤政彦, 山田佳之
    • Organizer
      第60回日本アレルギー学会秋季学術大会
    • Place of Presentation
      東京
    • Year and Date
      2010-11-26
    • Related Report
      2010 Final Research Report
  • [Presentation] 小児消化管アレルギー小児での食道好酸球浸潤に関する後方視的検討 小児好酸球性食道炎患者は存在したか2010

    • Author(s)
      山田佳之, 加藤政彦
    • Organizer
      第60回日本アレルギー学会秋季学術大会
    • Place of Presentation
      東京
    • Year and Date
      2010-11-26
    • Related Report
      2010 Annual Research Report 2010 Final Research Report
  • [Presentation] 小児好酸球増多患者における末梢血CRTH2陽性Natural killer T細胞発現の検討2010

    • Author(s)
      山田佳之
    • Organizer
      第57回日本臨床検査医学会学術集会
    • Place of Presentation
      東京
    • Year and Date
      2010-09-11
    • Related Report
      2010 Annual Research Report 2010 Final Research Report
  • [Presentation] 好酸球性食道炎、好酸球性胃腸炎症候群について2010

    • Author(s)
      山田佳之
    • Organizer
      第8回(平成22年度第1回)新生児-乳児アレルギー疾患研究会
    • Place of Presentation
      東京
    • Year and Date
      2010-08-06
    • Related Report
      2010 Annual Research Report 2010 Final Research Report
  • [Presentation] 好酸球性胃腸疾患の4例2010

    • Author(s)
      山田佳之, 西明, 江原佳史, 加藤政彦, 林泰秀
    • Organizer
      アレルギー好酸球研究会2010
    • Place of Presentation
      東京
    • Year and Date
      2010-06-19
    • Related Report
      2010 Final Research Report
  • [Presentation] 好酸球性胃腸疾患の4例2010

    • Author(s)
      山田佳之、西明、江原佳史、加藤政彦、林泰秀
    • Organizer
      アレルギー・好酸球研究会
    • Place of Presentation
      東京
    • Year and Date
      2010-06-19
    • Related Report
      2010 Annual Research Report
  • [Presentation] アスピリン喘息 疾患の紹介 好酸球性胃腸炎(ミニシンポジウム)2010

    • Author(s)
      山田佳之
    • Organizer
      第22回日本アレルギー学会春季臨床大会
    • Place of Presentation
      京都
    • Year and Date
      2010-05-08
    • Related Report
      2010 Final Research Report
  • [Presentation] アスピリン喘息疾患の紹介好酸球性胃腸炎2010

    • Author(s)
      山田佳之
    • Organizer
      第22回日本アレルギー学会春季臨床大会
    • Place of Presentation
      京都
    • Year and Date
      2010-05-08
    • Related Report
      2010 Annual Research Report
  • [Presentation] 気管支喘息発作時の原因ウイルスの同定とサイトカイン産生、好酸球活性化の検討(続報)2010

    • Author(s)
      加藤政彦, 山田佳之, 丸山健一, 林泰秀
    • Organizer
      第113回日本小児科学会学術集会
    • Place of Presentation
      岩手
    • Year and Date
      2010-04-23
    • Related Report
      2010 Annual Research Report 2010 Final Research Report
  • [Presentation] 新生児・乳児消化管アレルギーの3例2010

    • Author(s)
      山田佳之, 江原佳史, 加藤政彦, 林泰秀
    • Organizer
      第113回日本小児科学会学術集会
    • Place of Presentation
      岩手
    • Year and Date
      2010-04-23
    • Related Report
      2010 Annual Research Report 2010 Final Research Report
  • [Presentation] Higher Frequency of Circulating CRTH2+ Natural Killer T Cells in Pediatric Patients with Eosinophilia.2010

    • Author(s)
      Yamada Y, Kourakata K, Kato M, Hayashi Y
    • Organizer
      American Academy of Allergy, Asthma and Immunology 2010 Annual Meeting.
    • Place of Presentation
      New Orleans, U.S.A.
    • Year and Date
      2010-02-27
    • Related Report
      2010 Final Research Report
  • [Presentation] Higher Frequency of Circulating CRTH2+ Natural Killer T Cells in Pediatric Patients with Eosinophilia2010

    • Author(s)
      Yamada Y, Kourakata K, Kato M, Hayashi Y.
    • Organizer
      American Academy of Allergy, Asthma and Immunology 2010 Annual Meeting
    • Place of Presentation
      New Orleans, U.S.A.
    • Year and Date
      2010-02-27
    • Related Report
      2009 Annual Research Report
  • [Presentation] 結腸狭窄を認めた新生児・乳児消化管アレルギーの一例2009

    • Author(s)
      江原佳史, 山田佳之, 中嶋直樹, 西明, 畠山信逸, 丸山健一, 林泰秀
    • Organizer
      第46回日本小児アレルギー学会
    • Place of Presentation
      福岡
    • Year and Date
      2009-12-06
    • Related Report
      2010 Final Research Report 2009 Annual Research Report
  • [Presentation] 注目される好酸球関連疾患 好酸球性胃腸炎(ワークショップ)2009

    • Author(s)
      山田佳之
    • Organizer
      第59回日本アレルギー学会秋季学術大会
    • Place of Presentation
      秋田
    • Year and Date
      2009-10-30
    • Related Report
      2010 Final Research Report
  • [Presentation] 注目される好酸球関連疾患「好酸球性胃腸炎」2009

    • Author(s)
      山田佳之
    • Organizer
      第59回日本アレルギー学会秋季学術大会
    • Place of Presentation
      秋田
    • Year and Date
      2009-10-30
    • Related Report
      2009 Annual Research Report
  • [Presentation] 好酸球と臨床・アレルギー病態 好酸球炎症と好酸球増多 好酸球増多をともなったBaraitser-Winter症候群の一例2009

    • Author(s)
      山田佳之, 加藤政彦
    • Organizer
      第59回日本アレルギー学会秋季学術大会
    • Place of Presentation
      秋田
    • Year and Date
      2009-10-29
    • Related Report
      2010 Final Research Report
  • [Presentation] 好酸球増多をともなった Baraitser-Winter 症候群の一例2009

    • Author(s)
      山田佳之、加藤政彦
    • Organizer
      第59回日本アレルギー学会秋季学術大会
    • Place of Presentation
      秋田
    • Year and Date
      2009-10-29
    • Related Report
      2009 Annual Research Report
  • [Presentation] 好酸球と炎症性疾患2009

    • Author(s)
      山田佳之
    • Organizer
      第29回小児臨床検査研究会
    • Place of Presentation
      渋川(群馬)(教育講演)
    • Year and Date
      2009-10-17
    • Related Report
      2010 Final Research Report
  • [Presentation] 好酸球性炎症とその評価2009

    • Author(s)
      山田佳之
    • Organizer
      第29回小児臨床検査研究会
    • Place of Presentation
      渋川市(群馬)
    • Year and Date
      2009-10-17
    • Related Report
      2009 Annual Research Report
  • [Presentation] 好酸球と炎症性疾患2009

    • Author(s)
      山田佳之
    • Organizer
      第10回 文翔館呼吸器研究会
    • Place of Presentation
      山形
    • Year and Date
      2009-09-18
    • Related Report
      2009 Annual Research Report
  • [Presentation] 好酸球と炎症性疾患2009

    • Author(s)
      山田佳之
    • Organizer
      第10回文翔館呼吸器研究会
    • Place of Presentation
      山形(特別講演)
    • Year and Date
      2009-09-08
    • Related Report
      2010 Final Research Report
  • [Presentation] 小児好酸球増多患者におけるFIP1L1/PDGFRA融合遺伝子発現の検討2009

    • Author(s)
      山田佳之
    • Organizer
      第56回日本臨床検査医学会学術集会
    • Place of Presentation
      札幌
    • Year and Date
      2009-08-27
    • Related Report
      2010 Final Research Report
  • [Presentation] 小児好酸球増多患者におけるFIP1L1/PDGFRA融合遺伝子発現2009

    • Author(s)
      山田佳之
    • Organizer
      第56回日本臨床検査医学会学術集会
    • Place of Presentation
      札幌
    • Year and Date
      2009-08-27
    • Related Report
      2009 Annual Research Report
  • [Presentation] FIP1L1/PDGFRA陽性好酸球増多症候群/好酸球性白血病(HES/CEL)マウスモデルにおける肥満細胞症2009

    • Author(s)
      山田佳之, Cancelas JA, Rothenberg ME
    • Organizer
      アレルギー好酸球研究2009
    • Place of Presentation
      東京
    • Year and Date
      2009-06-20
    • Related Report
      2010 Final Research Report
  • [Presentation] FIP1L1/PDGFRA陽性好酸球増多症候群/好酸球性白血病(HES/CEL)マウスモデルにおける肥満細胞症2009

    • Author(s)
      山田佳之、Cancelas JA, Rothenberg ME.
    • Organizer
      アレルギー好酸球研究会2009
    • Place of Presentation
      東京
    • Year and Date
      2009-06-20
    • Related Report
      2009 Annual Research Report

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Published: 2009-04-01   Modified: 2016-04-21  

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