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Analysis of genes involved inβ-catenin degradation in nephroblastoma

Research Project

Project/Area Number 21791021
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeSingle-year Grants
Research Field Pediatrics
Research Institution埼玉県立がんセンター (2011)
Research Institute for Clinical Oncology, Saitama Cancer Center (2009-2010)

Principal Investigator

HARUTA Masayuki  埼玉県立がんセンター, 臨床腫瘍研究所, 研究員 (80392190)

Project Period (FY) 2009 – 2011
Project Status Completed (Fiscal Year 2011)
Budget Amount *help
¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2011: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2010: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2009: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Keywords腎芽腫 / 遺伝子異常 / βカテニン / WTX
Research Abstract

More than half of nephroblastoma didn't show abnormalities in responsible genes for tumorigenesis in fetal kidney. Therefore, there may be mutations in other tumor suppressor genes. Abnormalities of WTX and CTNNB known as tumor suppressor genes involved in WNT signaling pathway were detected in 22.8% and 26.3% of the 114 nephroblastomas. SNP array analysis clarified chromosomal abnormalities of APC(5q21-22), AXIN1(16p13) or AXIN2(17q23-24) coding regions in a little bit of cases. By direct sequencing analysis, a mutation of APC gene was indentified in one of 59 tumors which didn't have any abnormalities in known responsible genes. Patients with an abnormality in WTX gene were poor outcome than those without(p=0.0402).

Report

(4 results)
  • 2011 Annual Research Report   Final Research Report ( PDF )
  • 2010 Annual Research Report
  • 2009 Annual Research Report
  • Research Products

    (29 results)

All 2012 2011 2010 2009 Other

All Journal Article (14 results) (of which Peer Reviewed: 11 results) Presentation (14 results) Remarks (1 results)

  • [Journal Article] Different incidences ofepigenetic but not genetic abnormalities between Wilms tumors in Japanese and Caucasian children2012

    • Author(s)
      M, AraiY, Watanabe N, Fujiwara Y, Honda S, Ohshima J, Kasai F, Nakadate H, Horie H, Okita H, Hata JI, Fukuzawa M, Kaneko Y
    • Journal Title

      Cancer Sci

      Volume: (in press)

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Methylation of the RASSF1A promoteris predictive of poor outcome among patients with Wilms tumor2012

    • Author(s)
      Ohshima J, Haruta M, Fujiwara Y, WatanabeN, Arai Y, Ariga T, Okita H, Koshinaga T, Oue T, Hinotsu S, Nakadate H, Horie H, Fukuzawa M, Kaneko Y
    • Journal Title

      Pediatr Blood Cancer

      Volume: (in press)

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Different incidences of epigenetic but not genetic abnormalities between Wilms tumors in Japanese and Caucasian children2012

    • Author(s)
      Haruta M., et.al.
    • Journal Title

      Cancer Science

      Volume: (In press) Issue: 6 Pages: 1129-35

    • DOI

      10.1111/j.1349-7006.2012.02269.x

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Methylation of the RASSF1A promoter is predictive of poor outcome among patients with Wilms tumor2012

    • Author(s)
      Ohshima J, Haruta M, Fujiwara W, Watanabe N, Arai Y, Ariga T, Okita H, Koshinaga T, Oue T, Hinotsu S, Nakadate H, Horie H, Fukuzawa M, Kaneko Y
    • Journal Title

      Pediatr Blood Cancer

      Volume: 59 Issue: 3 Pages: 499-505

    • DOI

      10.1002/pbc.24093

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Association of germline or somatic TP53 missense mutation with oncogene amplification in tumors developed in patients with Li-Fraumeni or Li-Fraumeni-like syndrome2011

    • Author(s)
      Sugawara W., et.al.
    • Journal Title

      Genes Chromosomes Cancer

      Volume: 50 Issue: 7 Pages: 535-545

    • DOI

      10.1002/gcc.20878

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Genome-wide analysis of allelic imbalances reveals 4q deletions as a poor prognostic factor and MDM4 amplification at 1q32.1 in hepatoblastoma2010

    • Author(s)
      Arai Y, Honda S, Haruta M, Kasai F, Fujiwara Y, Ohshima J, Sasaki F, Nakagawara A, Horie H, Yamaoka H, Hiyama E, Kaneko Y.
    • Journal Title

      Genes Chromosomes Cancer

      Volume: 49 Pages: 596-609

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] 小児腫瘍から学ぶ臓器形成におけるWntシグナリングの重要性2010

    • Author(s)
      金子安比古,春田雅之
    • Journal Title

      小児がん

      Volume: 47 Pages: 252-6

    • Related Report
      2011 Final Research Report
  • [Journal Article] Genome wide analysis of allelic imbalances reveals 4q deletions as a poor prognostic factor and MDM4 amplification at 1q32.1 in hepatoblastoma2010

    • Author(s)
      Arai Y, Honsa S, Haruta M, et.al.
    • Journal Title

      Genes Chromosomes Cancer

      Volume: 49 Pages: 596-609

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 小児腫瘍から学ぶ臓器形成におけるWntシグナリングの重要性2010

    • Author(s)
      金子安比古、春田雅之
    • Journal Title

      小児がん

      Volume: 47 Pages: 252-256

    • Related Report
      2010 Annual Research Report
  • [Journal Article] Genome-wide analysis of allelic imbalances reveals 4q deletions as a poor prognostic factor and MDM4 amplification at 1q32.1 in hepatoblastoma2010

    • Author(s)
      Arai Y, Honsa S, Haruta M, et. al.
    • Journal Title

      Genes Chromosomes Cancer 49

      Pages: 596-609

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Two candidate tumor suppressor genes, MEOX2 and SOSTDC1, identified in a 7p21 homozygous deletion region in a Wilm stumor2009

    • Author(s)
      Ohshima J, Haruta M, Arai Y, Kasai F, Fujiwara Y, Ariga T, Okita H, Fukuzawa M, Hata J, Horie H, Kaneko Y
    • Journal Title

      Genes Chromosomes Cancer

      Volume: 48 Pages: 1037-50

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Wilms腫瘍の分子生物学:最新の知見2009

    • Author(s)
      金子安比古,春田雅之
    • Journal Title

      小児がん

      Volume: 46 Pages: 282-6

    • NAID

      110007359158

    • Related Report
      2011 Final Research Report
  • [Journal Article] Two candidate tumor suppressor genes, MEOX2 and SOSTDC1, identified in a 7p21 homozygous deletion region in a Wilms tumor.2009

    • Author(s)
      Ohshima J, Haruta M, et. al
    • Journal Title

      Genes Chromosomes Cancer 48

      Pages: 1037-1050

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Association of germline or somatic TP53 missense mutation with oncogene amplification in tumors developed inpatients with Li-Fraumeni or Li-Fraumeni-like syndrome

    • Author(s)
      Sugawara W, Arai Y, Kasai F, Fujiwara Y, Haruta M
    • Journal Title

      Genes Chromosomes Cancer

      Volume: (In press)

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Presentation] がん抑制遺伝子RASSF1Aのプロモーターメチル化はWilms腫瘍の予後不良因子である2011

    • Author(s)
      大島淳二,郎春田雅之, 他
    • Organizer
      第53回日本小児血液・がん学会学術集会
    • Place of Presentation
      前橋
    • Related Report
      2011 Final Research Report
  • [Presentation] がん抑制遺伝子RASSF1Aのプロモーターメチノレ化はWilms腫瘍の予後不良因子である2011

    • Author(s)
      大島淳二郎, 他
    • Organizer
      第53回日本小児血液・がん学会学術集会
    • Place of Presentation
      前橋
    • Related Report
      2011 Annual Research Report
  • [Presentation] 高密度SNPアレイによる網羅的ゲノム解析および刷り込み遺伝子のメチル化解析を用いた胚細胞腫瘍発生機構の解明2011

    • Author(s)
      市川瑞穂, 他
    • Organizer
      第53回日本小児血液・がん学会学術集会
    • Place of Presentation
      前橋
    • Related Report
      2011 Annual Research Report
  • [Presentation] SNP array patterns in Wilms tumors with the possibility of abnormalities of unknown genes responsible for tomorigenesis2010

    • Author(s)
      Haruta M, et. al
    • Organizer
      第69回日本癌学会学術総会
    • Place of Presentation
      大阪
    • Related Report
      2011 Final Research Report 2010 Annual Research Report
  • [Presentation] The different incidence rate of Wilms in races profoundly contributes toIGF2 LOI, but not abnormality of WT1, WTX and CTNNB12010

    • Author(s)
      Haruta M, et. Al
    • Organizer
      AACR 101^<st> Annual Meeting
    • Place of Presentation
      Washington DC
    • Related Report
      2011 Final Research Report
  • [Presentation] The different incidence rate of Wilms in races profoundly contributes to IGF2LOI, but not abnormality of WT1, WTX and CTNNB1.2010

    • Author(s)
      Haruta M, et.al.
    • Organizer
      AACR 101^<st> Annual Meeting
    • Place of Presentation
      Washington DC
    • Related Report
      2010 Annual Research Report
  • [Presentation] TP53 germeline mutations may induce oncogene amplification in tumors developing in patients with Li-Fraumeni syndrome.2010

    • Author(s)
      Kaneko Y, Arai Y, Kasai F, Haruta M, et.al.
    • Organizer
      第69回日本癌学会学術総会
    • Place of Presentation
      大阪
    • Related Report
      2010 Annual Research Report
  • [Presentation] HER2 genomic copy mumber predicts response to trastuzumab-combined chemotherapy better than HER2 immunohistochemistry.2010

    • Author(s)
      Higuchi T, Kasai F, Haruta M, et.al.
    • Organizer
      第69回日本癌学会学術総会
    • Place of Presentation
      大阪
    • Related Report
      2010 Annual Research Report
  • [Presentation] SNPアレイ解析により検出された肝芽腫の4q欠失は予後不良因子である2009

    • Author(s)
      金子安比古、新井康仁、本多昌平、春田雅之, 他
    • Organizer
      第68回日本癌学会学術総会
    • Place of Presentation
      パシフィコ横浜
    • Year and Date
      2009-10-03
    • Related Report
      2009 Annual Research Report
  • [Presentation] Wilms腫瘍の7p21ホモ欠失領域から同定された候補腫瘍抑制遺伝子MEOX2とSOTDC12009

    • Author(s)
      大島淳二郎、春田雅之, 他
    • Organizer
      第68回日本癌学会学術総会
    • Place of Presentation
      パシフィコ横浜
    • Year and Date
      2009-10-03
    • Related Report
      2009 Annual Research Report
  • [Presentation] ウィルムス腫瘍で初めて同定されたAPC遺伝子変異2009

    • Author(s)
      春田雅之, 他
    • Organizer
      第68回日本癌学会学術総会
    • Place of Presentation
      パシフィコ横浜
    • Year and Date
      2009-10-01
    • Related Report
      2009 Annual Research Report
  • [Presentation] Loss of Heterozygosity Analysis in Wilms Tumor2009

    • Author(s)
      Padilla R, Haruta M, et. al
    • Organizer
      ASHG 59th Annual Meeting
    • Place of Presentation
      Honolulu
    • Related Report
      2011 Final Research Report
  • [Presentation] ウィルムス腫瘍で初めて同定されたAPC遺伝子変異2009

    • Author(s)
      春田雅之, 他
    • Organizer
      第68回日本癌学会学術総会
    • Place of Presentation
      横浜
    • Related Report
      2011 Final Research Report
  • [Presentation] Wilms腫瘍の7p21ホモ欠失領域から同定された候補腫瘍抑制遺伝子MEOX2とSOTDC12009

    • Author(s)
      大島淳二郎春田雅之, 他
    • Organizer
      第68回日本癌学会学術総会
    • Place of Presentation
      横浜
    • Related Report
      2011 Final Research Report
  • [Remarks]

    • URL

      http://www.saitama-cc.jp/rinsyousyuyou_labo/index.html

    • Related Report
      2011 Final Research Report

URL: 

Published: 2009-04-01   Modified: 2016-04-21  

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