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Expression regulation of basement membrane proteins by transcription factor of epithelial to mesenchymal transition

Research Project

Project/Area Number 21791055
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeSingle-year Grants
Research Field Dermatology
Research InstitutionHirosaki University

Principal Investigator

NAKAJIMA Koji  Hirosaki University, 大学院・医学研究科, 助教 (70374832)

Project Period (FY) 2009 – 2010
Project Status Completed (Fiscal Year 2010)
Budget Amount *help
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2010: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2009: ¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000)
Keywords遺伝子 / シグナル伝達 / 発現制御 / 転写因子
Research Abstract

Recent studies show that TGF-β is a key cytokine of EMT and zinc-finger transcription factor Snail also is a master transcription factor of EMT. Our group has been investigating on molecular mechanisms of expression regulation of basement membrane proteins and examining promoter analysis of BBAG1 and type VII collagen genes. The purpose of this study is to clarify how transcription factor Snail induced by TGF-β modulate expression of basement membrane proteins. The results showed that TGF-β induced expression of basement membrane proteins, resulting in suppression of EMT. Furthermore, transcription factor Snail played an important role in this phenomenon.

Report

(3 results)
  • 2010 Annual Research Report   Final Research Report ( PDF )
  • 2009 Annual Research Report

Research Products

(18 results)

All 2010 2009 2008 Other

All Journal Article Remarks

  • [Journal Article] Disseminated lupus vulgaris misdiagnosed as port-wine stain.2010

    • Author(s)
      Takeuchi S, Nakano H, Rokunohe D, Nishizawa A, Kenoko T, Aizu T, Nakajima K, Matsuzaki Y, Sawamura D.
    • Journal Title

      J Dermatol 37

      Pages: 916-918

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Proliferating trichilemmal tumor developing in nevus sebaceous.2010

    • Author(s)
      Takeda H, Ikenaga S, Kaneko T, Nakajima K, Harada K, Hanada K, Sawamura D.
    • Journal Title

      Eur J Dermatol 20

      Pages: 664-665

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Giant cutaneous granular cell tumour with papillomatous appearance.2010

    • Author(s)
      Rokunohe D, Nakano H, Oshima H, Nakajima K, Aizu T, Kaneko T, Sawamura D.
    • Journal Title

      Clin Exp Dermatol 35

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Multiple eruptive dermatofibromas associated with Hashimoto's thyroiditis and myasthenia gravis.2010

    • Author(s)
      Kimura Y, Kaneko T, Akasaka E, Nakajima K, Aizu T, Nakano H, Sawamura D.
    • Journal Title

      Eur J Dermatol 20

      Pages: 538-539

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Leukemia cutis is an early sign of blast transformation that may mimica common skin disease : sycosis-like eruptions in chronic myelomonocytic leukemia.2010

    • Author(s)
      Takeuchi S
    • Journal Title

      J Dermatol

      Volume: 37 Pages: 916-918

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Proliferating trichilemmal tumor developing in nevus sebaceous.2010

    • Author(s)
      Takeda H
    • Journal Title

      Eur J Dermatol

      Volume: 20 Pages: 664-665

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Giant cutaneous granular cell tumour with papillomatous appearance.2010

    • Author(s)
      Rokunohe D
    • Journal Title

      Clin Exp Dermatol

      Volume: 35

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Multiple eruptive dermatofibromas associated with Hashimoto's thyroiditis and myasthenia gravis.2010

    • Author(s)
      Kimura Y
    • Journal Title

      Ear J Dermatol

      Volume: 20 Pages: 538-539

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] A linear basal cell carcinoma undergoing spontaneous regression.2009

    • Author(s)
      Takiyoshi N, Nakano H, Kaneko T, Aizu T, Nakajima K, Akasaka E, Rokunohe D, Sawamura D.
    • Journal Title

      Clin Exp Dermatol 34

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Multiple desmoplastic trichoepitheliomas with ossification and cholesterol deposition.2009

    • Author(s)
      Takiyoshi N, Nakano H, Kaneko T, Aizu T, Nakajima K, Akasaka E, Rokunohe D, Sawamura D.
    • Journal Title

      Clin Exp Dermatol 34

      Pages: 634-635

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Dermascopy of eccrine poroma with calcification.2009

    • Author(s)
      Nishikawa Y, Kaneko T, Kakiyoshi N, Aizu T, Nakajima K, Matsuzaki Y, Nakano H, Sawamura D.
    • Journal Title

      J Dermatol Case Rep 3

      Pages: 52-54

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Significance of sentinel node biopsy in the management of squamous cell carcinoma arising from recessive dystrophic epidermolysis bullosa.2008

    • Author(s)
      Rokunohe A, Nakano H, Aizu T, Kaneko T, Nakajima K, Ikenaga S, Matsuzaki Y, Murai T, Tamai K, Sawamura D.
    • Journal Title

      J Dermatol 35

      Pages: 336-340

    • NAID

      10024297026

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Identification of Skn-1n, a splice variant that is induced by high calcium concentration and specifically expressed in normal human keratinocytes.2008

    • Author(s)
      Nakajima K, Tamai K, Yamazaki T, Toyomaki Y, Nakano H, Uitto J, Sawamura D.
    • Journal Title

      J Invest Dermatol 128

      Pages: 1336-1339

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Papillon-Lefevre syndrome and malignant melanoma : a high incidence of melanoma development in Japanese palmoplantar keratoderma patients.2008

    • Author(s)
      Nakajima K, Nakano H, Takiyoshi N, Rokunohe A, Ikenaga S, Aizu T, Kaneko T, Mitsuhashi Y, Sawamura D.
    • Journal Title

      Dermatology 217

      Pages: 58-62

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] A case of zosteriform metastatic skin cancer.2008

    • Author(s)
      Minakawa S, Nakajima K, Aizu T, Nomura K, Kaimori M.
    • Journal Title

      Clin Exp Dermatol 33

      Pages: 808-810

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] A de novo missense mutation in the keratin 13 gene in oral white sponge nevus.2008

    • Author(s)
      Nishizawa A, Nakajima K, Nakano H, Sawamura D, Satoh T, Yokozeki H.
    • Journal Title

      Br J Dermatol 159

      Pages: 974-975

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Significance of sentinel node biopsy in the management of squamous cell carcinomaarising from recessive dystrophic epidermolysis bullosa.2008

    • Author(s)
      Rokunohe A, Nakano H, Aizu T, Kaneko T, Nakajima K, Ikenaga S, Matsuzaki Y, Murai T, Tamai K, Sawamura D.
    • Journal Title

      J Dermatol 35

      Pages: 336-340

    • NAID

      10024297026

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Remarks] ホームページ等

    • Related Report
      2010 Final Research Report

URL: 

Published: 2009-03-31   Modified: 2016-04-21  

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