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Inactivated Sendai virus particles with an IL-2 gene exert anti-tumor effects on murine angiosarcoma

Research Project

Project/Area Number 21791065
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeSingle-year Grants
Research Field Dermatology
Research InstitutionTokyo Medical and Dental University

Principal Investigator

NISHIZAWA Aya  東京医科歯科大学, 大学院・医歯学総合研究科, 助教 (30431456)

Project Period (FY) 2009 – 2011
Project Status Completed (Fiscal Year 2011)
Budget Amount *help
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2011: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2010: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2009: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Keywords遺伝子治療 / 免疫療法 / 血管肉腫 / HVJ-E / スニチニブリンゴ酸塩 / IL-2 / ドセタキセル
Research Abstract

Cutaneous angiosarcoma is a malignant skin tumor with a high mortality rate despite the currently available therapeutic protocols.
Inactivated, replication-defective Sendai virus particles(HVJ-E) have been shown to have a powerful anti-tumor effect.
We aimed to establish a novel therapeutic tool for anigiosarcoma with HVJ-E, IL-2 gene, and/or sunitinib.
HVJ-E significantly inhibited tumor growth of angiosarcoma in vivo.
HVJ-E-containing murine IL-2 gene resulted in an even more significant inhibition of tumor growth than HVJ-E alone.
Anti-tumor effects of HVJ-E were associated with an increase of CD8(+) cells and NK cells, and a decrease of Tregs.
Sunitinib inhibits cell growth of ISOS-1 cells in vitro and in vivo.
The combination of the HVJ-E and Sunitinib resulted in an even more significant inhibition of tumor growth than HVJ-E alone.

Report

(4 results)
  • 2011 Annual Research Report   Final Research Report ( PDF )
  • 2010 Annual Research Report
  • 2009 Annual Research Report
  • Research Products

    (20 results)

All 2011 2010 2009

All Journal Article (8 results) (of which Peer Reviewed: 4 results) Presentation (11 results) Book (1 results)

  • [Journal Article] 歯性根尖病巣が原因と考えられた亜急性痒疹2011

    • Author(s)
      西澤綾、佐藤貴浩、横関博雄
    • Journal Title

      皮膚病診療

      Volume: 33巻12号 Pages: 1219-1222

    • Related Report
      2011 Annual Research Report 2011 Final Research Report
  • [Journal Article] 歯科金属アレルギーが原因と考えられた異汗性湿疹2011

    • Author(s)
      西澤綾片岡いづみ佐藤貴浩
    • Journal Title

      Visual Dermatology

      Volume: 10巻11号 Pages: 1170-1171

    • Related Report
      2011 Annual Research Report 2011 Final Research Report
  • [Journal Article] 歯科金属除去にて軽快した口腔粘膜扁平苔癬2011

    • Author(s)
      西澤綾佐藤昌佐藤貴浩
    • Journal Title

      Visual Dermatology

      Volume: 10巻11号 Pages: 1174-1175

    • Related Report
      2011 Annual Research Report 2011 Final Research Report
  • [Journal Article] 口腔粘膜の扁平苔癬2011

    • Author(s)
      西澤綾
    • Journal Title

      Monthly Book Derma

      Volume: 186巻 Pages: 27-33

    • Related Report
      2011 Annual Research Report 2011 Final Research Report
  • [Journal Article] 有棘細胞癌を発症したBowenoid papulosis2010

    • Author(s)
      西澤綾、佐藤貴浩、横関博雄
    • Journal Title

      皮膚病診療

      Volume: 32巻No.6 Pages: 623-626

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Hydroa vaciniforme with mucosal involvement and recalcitrant periodontitis and multiple virus re-activators after sun-exposure.2010

    • Author(s)
      Aya Nishizawa, Takahiro Satoh, Kaoru Takayama, Hiroo Yokozeki
    • Journal Title

      Acta Derm Venereol.

      Volume: Sep;90(5):498-501 Pages: 498-501

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Cowden syndrome : a novel mutation and overlooked glycogenic acanthosis in gingiva2009

    • Author(s)
      Nishizawa A, Satoh T, Watanabe R, Takayama K, Nakano H, Sawamura D, Yokozeki H.
    • Journal Title

      Br J Dermatol 160

      Pages: 1116-1118

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Haber's syndrome may be a clinical entity different from Dowling-Degos disease2009

    • Author(s)
      Nishizawa A, Nakano H, Satoh T, Takayama K, Sawamura D, Yokozaki H.
    • Journal Title

      Br J Dermatol 160

      Pages: 215-217

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Presentation] Hyperkeratotic type of palmoplantar eczematous reaction : a variant ofdyshidrotic eczema?2011

    • Author(s)
      Aya Nishizawa, Takahiro Satoh, Hiroo Yokozeki
    • Organizer
      The 36^<th> Annual Meeting of the Japanese Society for Investigateve
    • Place of Presentation
      Dermatology
    • Year and Date
      2011-12-09
    • Related Report
      2011 Final Research Report
  • [Presentation] Inactivated Sendai virus particleswith an IL-2 gene exert anti-tumoreffects on murine angiosarcoma2011

    • Author(s)
      Yuki Takehara, Takahiro Satoh, Aya Nishizawa, Mikio Masuzawa, Hiroo Yokozeki
    • Organizer
      The 36^<th> Annual Meeting of the Japanese Society for Investigateve
    • Place of Presentation
      Dermatology
    • Year and Date
      2011-12-09
    • Related Report
      2011 Final Research Report
  • [Presentation] Inactivated Sendai virus particles with an IL-2 gene exert anti-tumor effects on murine angiosarcoma2011

    • Author(s)
      Yuki Takehara, Takahiro Satoh, Aya Nishizawa, Mikio Masuzawa, Hiroo Yokozeki
    • Organizer
      The 36^<th> Annual Meeting of the Japanese Society for Investigateve Dermatology
    • Place of Presentation
      京都
    • Year and Date
      2011-12-09
    • Related Report
      2011 Annual Research Report
  • [Presentation] 扁平苔癬115例における金属アレルギーの関与に関する検討2011

    • Author(s)
      西澤綾、佐藤貴浩、横関博雄
    • Organizer
      第23回日本アレルギー学会春季臨床大会
    • Related Report
      2011 Annual Research Report 2011 Final Research Report
  • [Presentation] オメプラールによるnonpigmentingfixed drug eruption2011

    • Author(s)
      西澤綾、篠塚直子、田中智子、宮崎安洋、佐藤貴浩、横関博雄
    • Organizer
      第41回日本皮膚アレルギー接触皮膚炎学会
    • Related Report
      2011 Final Research Report
  • [Presentation] Hyperkeratotic type of palmoplantar eczematous reaction : a variant of dyshidrotic eczema?2011

    • Author(s)
      Aya Nishizawa, Takahiro Satoh, Hiroo Yokozeki
    • Organizer
      第36回日本研究皮膚科学会学術大会・総会
    • Place of Presentation
      京都市
    • Related Report
      2011 Annual Research Report
  • [Presentation] オメプラールによるnonpigmenting fixed drug eruption2011

    • Author(s)
      西澤綾、篠塚直子、田中智子、宮崎安洋、佐藤貴浩、横関博雄
    • Organizer
      第41回日本皮膚アレルギー接触皮膚炎学会
    • Place of Presentation
      山梨市
    • Related Report
      2011 Annual Research Report
  • [Presentation] 扁平苔癬115例における金属アレルギーの関与に関する検討2010

    • Author(s)
      西澤綾、佐藤貴浩、横関博雄
    • Organizer
      第40回皮膚アレルギー・接触皮膚炎学会総会学術大会
    • Place of Presentation
      広島市
    • Year and Date
      2010-12-10
    • Related Report
      2010 Annual Research Report
  • [Presentation] Close association between metal allergy and nail lichen planus versus oral lichen planus ; detection of causative metals in nail lesions2010

    • Author(s)
      Aya Nishizawa, Takahiro Satoh, Hiroo Yokozeki
    • Organizer
      第35回研究皮膚科学会学術大会総会
    • Place of Presentation
      和歌山市
    • Year and Date
      2010-12-03
    • Related Report
      2010 Annual Research Report
  • [Presentation] 悪性転化後に急速に進展したBowenoid papulosis2010

    • Author(s)
      西澤綾、佐藤貴浩、横関博雄
    • Organizer
      第21回日本臨床皮膚科医会 臨床学術会議
    • Place of Presentation
      倉敷市
    • Year and Date
      2010-10-23
    • Related Report
      2010 Annual Research Report
  • [Presentation] 難治性歯肉炎を繰り返し、皮膚病変でのEBV感染が証明されない種痘様水疱症2009

    • Author(s)
      西澤綾、高山かおる、佐藤貴浩、横関博雄
    • Organizer
      第825回 日本皮膚科学会合同臨床
    • Place of Presentation
      東京
    • Year and Date
      2009-07-25
    • Related Report
      2009 Annual Research Report
  • [Book] 病態生理 ビジュアルマップ52010

    • Author(s)
      西澤綾
    • Publisher
      医學書院
    • Related Report
      2010 Annual Research Report

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Published: 2009-04-01   Modified: 2016-04-21  

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