The role of SDF-1/CXCR4 signaling pathway on normal human keratinocyte
| Project/Area Number |
21791079
|
|---|
| Research Category |
Grant-in-Aid for Young Scientists (B)
|
| Allocation Type | Single-year Grants |
|---|
| Research Field |
Dermatology
|
|---|
| Research Institution | Ehime University |
|---|
Principal Investigator |
MIYAWAKI Saori Ehime University, 医学部附属病院, 医員 (90467853)
|
|---|
| Project Period (FY) |
2009 – 2010
|
| Project Status |
Completed (Fiscal Year 2010)
|
| Budget Amount *help |
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2010: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2009: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
|
|---|
| Keywords | 皮膚生理学 / 表皮角化細胞 / 細胞遊走 / SDF-1 / CXCR4 / シグナル伝達 |
|---|
| Research Abstract |
Recentry, several groups reported the expression of stromal cell-derived factor1(SDF-1 ; CXCL12) express on human skin. However, the biological meanings is still unkown. We found that SDF-1 induces keratinocyte migration in a dose dependent manner through EGF receptor via ERK(p42/44) activation.
|
Report
(3 results)
Research Products
(5 results)
