The role of SDF-1/CXCR4 signaling pathway on normal human keratinocyte

• Project/Area Number: 21791079
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Single-year Grants
• Research Field: Dermatology
• Research Institution: Ehime University
• Principal Investigator: MIYAWAKI Saori Ehime University, 医学部附属病院, 医員 (90467853)
• Project Period (FY): 2009 – 2010
• Project Status: Completed (Fiscal Year 2010)
• Budget Amount: ¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000); Fiscal Year 2010: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000); Fiscal Year 2009: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
• Keywords: 皮膚生理学 / 表皮角化細胞 / 細胞遊走 / SDF-1 / CXCR4 / シグナル伝達

Research Abstract

Recentry, several groups reported the expression of stromal cell-derived factor1(SDF-1 ; CXCL12) express on human skin. However, the biological meanings is still unkown. We found that SDF-1 induces keratinocyte migration in a dose dependent manner through EGF receptor via ERK(p42/44) activation.

Research Products

• [Journal Article] 薬剤性過敏症候群(DIHS)の特徴的な顔面の所見とHHV-6再活性化との時間的関係 (2009)
  • Author(s): 岡崎秀規、宮脇さおり、6番目、他6名
  • Journal Title: 日本皮膚科学会雑誌 119巻 Pages: 2187-2193
  • Peer Reviewed
• [Journal Article] 大量ガンマグロブリン静注療法が奏効した難治性尋常性天疱瘡の1例 (2009)
  • Author(s): 石川真奈美、宮脇さおり, 他
  • Journal Title: 西日本皮膚科 71 Pages: 561-565
  • Peer Reviewed
• [Journal Article] 薬剤性過敏症症候群(DIHS)の特徴的な顔面の所見とHHV-6再活性化との時間的関係 (2009)
  • Author(s): 岡崎秀規、宮脇さおり, 他
  • Journal Title: 日本皮膚科学会雑誌 119 Pages: 2187-2193
  • NAID: 10028277495
  • Peer Reviewed
• [Presentation] 脊髄炎で発症した血管内悪性リンパ腫に対しリツキマブが奏功した1例 (2010)
  • Author(s): 藤岡智仁、宮脇さおり、9番目、他7名
  • Organizer: 第102回日本内科学会四国地方会
  • Place of Presentation: 徳島
  • Year and Date: 2010-05-30
• [Book] 物理化学的皮膚障害、査読あり (2009)
  • Author(s): 宮脇さおり
  • Publisher: 皮膚科ナーシングプラクティス