Cell adhesion molecules regulate fibrotic process in a bleomycin-induced scleroderma model.
| Project/Area Number |
21791082
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Dermatology
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| Research Institution | 長崎医療センター (2010)
Nagasaki University (2009) |
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Principal Investigator |
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| Project Period (FY) |
2009 – 2010
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| Project Status |
Completed (Fiscal Year 2010)
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| Budget Amount *help |
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2010: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2009: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
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| Keywords | 強皮症 / 細胞接着分子 / 動物モデル / T細胞 / 全身性強皮症 / Th細胞 / マウスモデル / 自己免疫 |
|---|
| Research Abstract |
This study suggests that L-selectin and ICAM-1 regulate Th2 and Th17 cell accumulation into the skin and lung, leading to the development of fibrosis, and that P-selectin, E-selectin, and PSGL-1 regulate Th1 cell infiltration, resulting in the inhibition of fibrosis.
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Report
(3 results)
Research Products
(19 results)
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[Journal Article] Treatment with rapamycin prevents fibrosis in tight-skin and bleomycin-induced mouse models of systemic sclerosis.2010
Author(s)
Yoshizaki A, Yanaba K, Yoshizaki As, Iwata Y, Komura K, Ogawa F, Takenaka M, Shimizu K, Asano Y, Hasegawa M, Fujimoto M, Sato S.
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Journal Title
Arthritis Rheum. 62(8)
Pages: 2476-2487
Related Report
Peer Reviewed
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[Journal Article] Cell adhesion molecules regulate fibrotic process via Th1/Th2/Th17 cell balance in a bleomycin-induced scleroderma model.2010
Author(s)
Yoshizaki A, Yanaba K, Iwata Y, Komura K, Ogawa A, Akiyama Y, Muroi E, Hara T, Ogawa F, Takenaka M, Shimizu K, Hasegawa M, Fujimoto M, T fF Tedder, Sato S.
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Journal Title
J Immunol. 185(4)
Pages: 2502-2515
Related Report
Peer Reviewed
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[Journal Article] Clinical significance of serum HMGB-1 and sRAGE levels in systemic sclerosis : association with disease severity.2009
Author(s)
Yoshizaki A, Komura K, Iwata Y, Ogawa F, Hara T, Muroi E, Takenaka M, Shimizu K, Hasegawa M, Fujimoto M, Sato S.
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Journal Title
J Clin Immunol. 29(2)
Pages: 180-189
Related Report
Peer Reviewed
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