Elucidation of possible functional mechanisms of secretory phospholipase A2 in skin pathophysiology

• Project/Area Number: 21791106
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Single-year Grants
• Research Field: Dermatology
• Research Institution: 財団法人東京都医学研究機構 (2010); Tokyo Metropolitan Organization for Medical Research (2009)
• Principal Investigator: YAMAMOTO Kei 財団法人東京都医学研究機構, 東京都臨床医学総合研究所, 主任研究員 (30304504)
• Project Period (FY): 2009 – 2010
• Project Status: Completed (Fiscal Year 2010)
• Budget Amount: ¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000); Fiscal Year 2010: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000); Fiscal Year 2009: ¥2,860,000 (Direct Cost: ¥2,200,000、Indirect Cost: ¥660,000)
• Keywords: 脂質生化学 / 皮膚科学 / ホスホリパーゼA_2 / 皮膚生理 / ホスホリパーゼA2 / 遺伝子改変マウス / 脂肪酸

Research Abstract

Although lipid metabolism is thought to be important for proper keratinocyte differentiation and skin barrier function, the molecular mechanisms that underlie these processes in the epidermis remain incompletely understood. We now show that group IIF PLA_2, a member of the sPLA2 family, is dominantly expressed in the suprabasal layer of mouse epidermis and that gene-engineering of Pla2g2f in mice leads to dysregulated skin homeostasis. On the other hand. the spatiotemporal expression of sPLA_2-X in hair follicles, the presence of skin-specific machinery leading to sPLA_2-X activation, a functional link of sPLA2-X with hair follicle homeostasis, and compartmentalization of the prostanoid pathway in hair follicles and epidermis.

Research Products

• [Journal Article] Hair follicular expression and function of group X secreted phospholipase A_2 in mouse skin. (2011)
  • Author(s): Yamamoto, K., Taketomi, T., Isogai, Y., Miki, Y., Sato, H., Masuda, S., Nishito, Y., Morioka, K., Ishimoto, Y., Suzuki, N., Yokoya, Y., Hanasaki, K., Ishikawa, Y., Ishii, T., Kobayashi, T., Fukami, K., Ikeda, K., Nakanishi, H., Taguchi, R., Murakami
  • Journal Title: M.J.Biol.Chem. 286 Pages: 11616-11631
  • Peer Reviewed
• [Journal Article] Physiological roles of group X secreted phospholipase A_2 in reproduction, gastrointestinal phospholipid digestion, and neuronal function. (2011)
  • Author(s): Sato, H., Isogai, Y., Masuda, S., Taketomi, Y., Miki, Y., Kamei, D., Hara, S., Kobayashi, T., Ishikawa, Y., Ishii, T., Ikeda, K., Taguchi, R., Ishimoto, Y., Suzuki, N., Yokota, Y., Hanasaki, K., Suzuki-Yamamoto, T., Yamamoto, K., Murakami
  • Journal Title: M.J.Biol.Chem. 286 Pages: 11632-11648
  • Peer Reviewed
• [Journal Article] Recent progress in phospholipase A_2 research : from cells to animals to humans. (2011)
  • Author(s): Murakami, M., Taketomi, Y., Miki, Y., Sato, H., Hirabayashi, T., Yamamoto
  • Journal Title: K.Prog.Lipid Res. 50 Pages: 152-192
  • Peer Reviewed
• [Journal Article] Secreted phospholipase A_2, lipoprotein hydrolysis, and atherosclerosis : integration with lipidomics. (2011)
  • Author(s): Yamamoto, K., Isogai, Y., Sato, H., Taketomi, Y., Murakami
  • Journal Title: M.Anal.Bioanal.Chem. (in press)
  • Peer Reviewed
• [Journal Article] Integrated lipidomics in the secreted phospholipase A_2 biology. (2011)
  • Author(s): Murakami, M., Taketomi, Y., Sato, H., Yamamoto
  • Journal Title: K.Int.J.Mol.Sci. 12 Pages: 1474-1495
  • Peer Reviewed
• [Journal Article] ホスホリパーゼA_2 (2011)
  • Author(s): 山本圭、村上誠
  • Journal Title: 生化学 (印刷中)
  • NAID: 10029068557
  • Peer Reviewed
• [Journal Article] 高脂血症 (2011)
  • Author(s): 佐藤弘泰、武富芳隆、山本圭、村上誠
  • Journal Title: 生命科学研究の戦略:疾患モデルマウスと表現型解析 (印刷中)
  • Peer Reviewed
• [Journal Article] Hair follicular expression and function of group X secreted phospholipase A_2 in mouse skin. (2011)
  • Author(s): Yamamoto, K., et.al
  • Journal Title: J.Biol.Chem. Volume: 286 Pages: 11616-11631
  • Peer Reviewed
• [Journal Article] Physiological roles of group X secreted phospholipase A_2 in reproduction, gastrointestinal phospholipid digestion, and neuronal function (2011)
  • Author(s): Sato, H., et.al
  • Journal Title: J.Biol.Chem. Volume: 286 Pages: 11632-11648
  • Peer Reviewed
• [Journal Article] Recent progress in phospholipase A_2 research : from cells to animals to humans. (2011)
  • Author(s): Murakami, M., et.al
  • Journal Title: Prog.Lipid Res. Volume: 50 Pages: 152-192
  • Peer Reviewed
• [Journal Article] Integrated lipidomics in the secreted phospholipase A_2 biology. (2011)
  • Author(s): Murakami, M., et.al
  • Journal Title: Int.J.Mol.Sci. Volume: 12 Pages: 11632-11648
  • Peer Reviewed
• [Journal Article] Group III secreted phospholipase A_2 regulates epididymal sperm maturation and fertility (2010)
  • Author(s): Sato, H., Taketomi, Y., Isogai, Y., Miki, Y., Yamamoto, K., Masuda, S., Hosono, T., Arata, S., Ishikawa, Y., Ishii, T., Kobayashi, T., Nakanishi, H., Ikeda, K., Taguchi, R., Hara, S., Kudo, I., Murakami
  • Journal Title: M.J.Clin.Invest. 120 Pages: 1400-1414
  • Peer Reviewed
• [Journal Article] Group X phospholipase A_2 is released during sperm acrosome reaction and controls fertility outcome in mice. (2010)
  • Author(s): Escoffier, J., Jemel, I., Tanemoto, A., Taketomi, Y., Payre, C., Coatrieux, C., Sato, H., Yamamoto, K., Masuda, S., Pernet-Gallay, K., Pierre, V., Hara, S., Murakami, M., Waard, M.D., Lambeau, G., Arnoult
  • Journal Title: C.J.Clin.Invest. 120 Pages: 1415-1428
  • Peer Reviewed
• [Journal Article] Emerging roles of secreted phospholipase A_2 enzymes : lessons from transgenic and knockout mice. (2010)
  • Author(s): Murakami, M., Taketomi, Y., Girard, G., Yamamoto, K., Lambeau, G.
  • Journal Title: Biochimie 92 Pages: 561-582
  • Peer Reviewed
• [Journal Article] ホスホリパーゼA_2の生理的・病理的役割 (2010)
  • Author(s): 村上誠、佐藤弘泰, 平林哲也, 山本圭, 武富芳隆
  • Journal Title: 実験医学 28(20) Pages: 114-125
  • Peer Reviewed
• [Journal Article] Group III secreted phospholipase A_2 regulates epididymal sperm maturati on and fertility (2010)
  • Author(s): Sato, H., et.al
  • Journal Title: J.Clin.Invest. Volume: 120 Pages: 1400-1414
  • Peer Reviewed
• [Journal Article] Group X phospholipase A2 is released during sperm acrosome reaction and controls fertility outcome in mice. (2010)
  • Author(s): Escoffier, J., et.al
  • Journal Title: J.Clin.Invest. Volume: 120 Pages: 1415-1428
  • Peer Reviewed
• [Journal Article] Emerging roles of secreted phospholipase A_2 enzymes : lessons from trans genic and knockout mice. (2010)
  • Author(s): Murakami, M., et.al
  • Journal Title: Biochimie Volume: 92 Pages: 561-582
  • Peer Reviewed
• [Journal Article] ホスホリパーゼA_2の生理的・病理的役割 (2010)
  • Author(s): 村上誠, ら
  • Journal Title: 実験医学 Volume: 28 Pages: 114-125
  • Peer Reviewed
• [Journal Article] Group III secreted phospholipase A_2 transgenic mice spontaneously develop inflammation. (2009)
  • Author(s): Sato, H., et. al
  • Journal Title: Biochem. J. 421 Pages: 17-27
  • Peer Reviewed
• [Journal Article] Distribution of smooth muscle cells and macrophages expressing scavenger receptor Bi/II in atherosclerosis. (2009)
  • Author(s): Ishikawa, Y., et. al
  • Journal Title: J.Atheroscler.Throm. 16 Pages: 829-839
  • Peer Reviewed
• [Journal Article] ボスホリパーゼA_2と炎症 (2009)
  • Author(s): 山本圭、村上誠
  • Journal Title: 炎症と免疫 17 Pages: 359-365
• [Presentation] sPLA_2-IIF, an epidermal sPLA_2, regulates epidermal homeostasis and pathology. (2010)
  • Author(s): 山本圭、下華奈子、三木寿美、武富芳隆、池田和貴、中西広樹、田口良、村上誠
  • Organizer: BMB2010.
  • Place of Presentation: 神戸
  • Year and Date: 2010-12-10
• [Presentation] sPLA_2-V, an adipocyte-inducible metabolic sPLA_2, controls systemic lipid metabolism. (2010)
  • Author(s): 佐藤弘泰、武富芳隆、山本圭、石川由紀雄、石井寿晴、原俊太郎、村上誠
  • Organizer: BMB2010.
  • Place of Presentation: 神戸
  • Year and Date: 2010-12-10
• [Presentation] sPLA_2-IID, a dendritic cell-derived resolving sPLA_2, plays a role in resolution of inflammation (2010)
  • Author(s): 三木寿美、山本圭、下華奈子、武富芳隆、中西広樹、田口良、村上誠
  • Organizer: BMB2010.
  • Place of Presentation: 神戸
  • Year and Date: 2010-12-10
• [Presentation] sPLA_2-III, a mast cell-derived anaphylactic sPLA_2, regulates mast cell-dependent anaphylactic response. (2010)
  • Author(s): 武富芳隆、佐藤弘泰、田中智、中村正則、上野紀子、西藤泰昌、山本圭、杉本幸彦、原俊太郎、村上誠
  • Organizer: BMB2010.
  • Place of Presentation: 神戸
  • Year and Date: 2010-12-10
• [Presentation] Novel lipid-metabolizing enzyme induced in sebocytes. (2010)
  • Author(s): 平林哲也、島村透、横山浩平、上野紀子、池田和貴、山本圭、片桐千仭、田口良、村上誠
  • Organizer: BMB2010.
  • Place of Presentation: 神戸
  • Year and Date: 2010-12-07
• [Presentation] リピドミクスの生化学への適用:マスト細胞の分化成熟と活性化におけるリン脂質組成の包括的解析 (2010)
  • Author(s): 上野紀子、武富芳隆、池田和貴、山本圭、村上誠、田口良
  • Organizer: 第58回脂質分析総合討論会
  • Place of Presentation: つくば
  • Year and Date: 2010-06-18
• [Presentation] 皮膚特異的分泌性ホスホリパーゼA_2の病態生理機能 (2010)
  • Author(s): 山本圭、武富芳隆、三木寿美、下華奈子、池田和貴、中西広樹、田口良、Michal H.Gelb、村上誠
  • Organizer: 第52回日本脂質生化学会
  • Place of Presentation: 伊香保
  • Year and Date: 2010-06-15
• [Presentation] III型分泌性ホスホリパーゼA_2の欠損はメタボリックシンドロームを改善する (2010)
  • Author(s): 佐藤弘泰、磯貝有紀、武富芳隆、山本圭、石川由紀雄、石井壽晴、小林哲幸、中西広樹、池田和貴、田口良、原俊太郎、村上誠
  • Organizer: 第52回日本脂質生化学会
  • Place of Presentation: 伊香保
  • Year and Date: 2010-06-15
• [Presentation] 皮膚特異的分泌性ホスホリパーゼA_2の病態生理機能 (2010)
  • Author(s): 山本圭, ら
  • Organizer: 第52回日本脂質生化学会
  • Place of Presentation: 伊香保(群馬県)
  • Year and Date: 2010-06-15
• [Presentation] III型分泌性ホスホリパーゼA_2の欠損はメタボリックシンドロームを改善する (2010)
  • Author(s): 佐藤弘泰, ら
  • Organizer: 第52回日本脂質生化学会
  • Place of Presentation: 伊香保(群馬県)
  • Year and Date: 2010-06-15
• [Presentation] New insights into the functions of secreted phospholipase A_2s : roles of group IIF phospholipase A2 in skin pathophysiology. (2010)
  • Author(s): Yamamoto, K., Shimo, K., Miki, Y., Ikeda, K., Nakanishi, H., Taguchi, R., Gelb, M.H., Murakami, M.
  • Organizer: 7^<th> GERLI Lipidmics Congress.
  • Place of Presentation: Anglet-Biarritz, France
• [Presentation] New insights into the functions of secreted phospholipase A_2s : Spla_2 in reproduction. (2010)
  • Author(s): Sato, H., Taketomi, Y., Yamamoto, K., Arnoult, C., Lambeau, G., Murakami, M.
  • Organizer: 7^<th> GERLI Lipidmics Congress.
  • Place of Presentation: Anglet-Biarritz, France
• [Presentation] Recent insights into the multiple molecular and functional properties of group X sPLA_2. (2010)
  • Author(s): Lambeau, G., Jemel, J., Escoffier, J., Ait-Oufella, H., Hiromi Li, H., Guillaume, C., Gora, S., Surrel, F., Coatrieux, C., Payre, C., Tanemoto, A., Taketomi, Y., Sato, H., Yamamoto, K., Arnoult, C., Mallat, Z., Gelb, M.H., Deregnaucourt, C., Ninio, E., Karabina, S., Murakami, M.
  • Organizer: 7^<th> GERLI Lipidmics Congress.
  • Place of Presentation: Anglet-Biarritz, France
• [Presentation] Secreted Phosholipase A_2, Lipid Mediators, and Immunity. (2010)
  • Author(s): Murakami, M., Taketomi, Y., Yamamoto, K.
  • Organizer: 14^<th> International Congress of Immunology.
  • Place of Presentation: Kobe, Japan
• [Presentation] An epidermal secreted phospholipase A_2 : roles of group IIF phospholipase A_2 in skin pathophysiology. (2010)
  • Author(s): Yamamoto, K., Takemomi, Y., Miki, Y., Shimo, K., Nakanishi, H., Ikeda, K., Taguchi, R., Gelb, M.H., Murakami, M.
  • Organizer: FASEB Summer Research Conferences on Phospholipid Metabolism.
  • Place of Presentation: Steamboat Springs, CO, USA
• [Presentation] A dendritic cell secreted phospholipase A_2 : roles of group IID phospholipase A_2 in resolution of inflammation. (2010)
  • Author(s): Miki, Y., Yamamoto, K., Shimo, K., Taketomi, Y., Nakanishi, H., Taguchi, R., Gelb, M.H., Hara, S., Murakami, M.
  • Organizer: FASEB Summer Research Conferences on Phospholipid Metabolism.
  • Place of Presentation: Steamboat Springs, CO, USA
• [Presentation] Roles of group IIF epidermal phospholipase A_2 in skin homeostasis and pathology. (2010)
  • Author(s): Yamamoto, K., Takemomi, Y., Miki, Y., Shimo, K., Nakanishi, H., Ikeda, K., Taguchi, R., Gelb, M.H., Murakami, M.
  • Organizer: Keystone Symposia.
  • Place of Presentation: Kyoto, Japan.
• [Presentation] Group III secreted phospholipase A_2 regulates epididymal sperm maturation and fertility in mice. (2010)
  • Author(s): Sato, H., Taketomi, Y., Yamamoto, K., Murakami, M.
  • Organizer: Keystone Symposia.
  • Place of Presentation: Kyoto, Japan.
• [Presentation] Group IID secreted phospholipase A_2 is expressed in dendritic cells and plays a role in resolution of inflammation. (2010)
  • Author(s): Miki, Y., Yamamoto, K., Shimo, K., Taketomi, Y., Nakanishi, H., Taguchi, R., Gelb, M.H., Murakami, M.
  • Organizer: Keystone Symposia.
  • Place of Presentation: Kyoto, Japan.
• [Presentation] Recent insights into the multiple molecular and functional properties of group X sPLA2. (2010)
  • Author(s): Lambeau, G., Jemel, J., Escoffier, J., Ait-Oufella, H., Hiromi Li, H., Guillaume, C., Gora, S., Surrel, F., Coatrieux, C., Payre, C., Taketomi, Y., Sato, H., Yamamoto, K., Arnoult, C., Mallat, Z., Gelb, M.H., Deregnaucourt, C., Ninio, E., Karabina, S., Murakami, M.
  • Organizer: Keystone Symposia.
  • Place of Presentation: Kyoto, Japan.
• [Presentation] Roles of group IIF epidermal phospholipase A_2 in skin homeostasis and pathology. (2010)
  • Author(s): Yamamoto, K., et.al
  • Organizer: Keystone Symposia.
  • Place of Presentation: Kyoto, Japan
• [Presentation] Group III secreted phospholipase A_2 regulates epididymal sperm maturation and fertility in mice. (2010)
  • Author(s): Sato, H., et.al
  • Organizer: Keystone Symposia.
  • Place of Presentation: Kyoto, Japan
• [Presentation] Group IID secreted phospholipase A_2 is expressed in dendritic cells and plays a role in resolution of inflammation. (2010)
  • Author(s): Miki, Y., et.al
  • Organizer: Keystone Symposia.
  • Place of Presentation: Kyoto, Japan
• [Presentation] Recent insights into the multiple molecular and functional properties of group X sPLA_2. (2010)
  • Author(s): Lambeau, G., et.al
  • Organizer: Keystone Symposia.
  • Place of Presentation: Kyoto, Japan
• [Presentation] Lipid Mediators, and Immunity. (2010)
  • Author(s): Murakami, M., et.al
  • Organizer: 14^<th> International Congress of Immunology
  • Place of Presentation: Kobe, Japan
• [Presentation] New insights into the functions of secreted phospholipase A_2s : roles of group IIF phospholipase A_2 in skin pathophysiology. (2010)
  • Author(s): Yamamoto, K., et.al
  • Organizer: 7^<th> GERLI Lipidmics Congress.
  • Place of Presentation: Anglet-Biarritz, France
• [Presentation] New insights into the functions of secreted phospholipase A_2s : sPLA_2 in reproduction. (2010)
  • Author(s): Sato, H., et.al
  • Organizer: 7^<th> GERLI Lipidmics Congress.
  • Place of Presentation: Anglet-Biarritz, France
• [Presentation] 樹状細胞に発現しているIID型分泌性ホスホリパーゼA_2の機能 (2009)
  • Author(s): 三木寿美、山本圭、武富芳隆、Gelb, M.H.、原俊太郎、村上誠
  • Organizer: 第82回日本生化学会
  • Place of Presentation: 神戸
  • Year and Date: 2009-10-24
• [Presentation] 樹状細胞に発現しているIID型分泌性ホスホリパーゼA2の機能 (2009)
  • Author(s): 三木寿美, ら
  • Organizer: 第82回日本生化学会
  • Place of Presentation: 神戸
  • Year and Date: 2009-10-24
• [Presentation] IIF型ホスホリパーゼA_2の皮膚生理機能 (2009)
  • Author(s): 山本圭、武富芳隆、三木寿美、池田和貴、中西広樹、西藤泰昌、Gelb, M.H.、田口良、村上誠
  • Organizer: 第82回日本生化学会
  • Place of Presentation: 神戸
  • Year and Date: 2009-10-22
• [Presentation] III型ホスホリパーゼA_2は精子成熟を制御する (2009)
  • Author(s): 佐藤弘泰、武富芳隆、山本圭、磯貝有紀、三木寿美、小林哲幸、池田和貴、中西広樹、田口良、原俊太郎、村上誠
  • Organizer: 第82回日本生化学会
  • Place of Presentation: 神戸
  • Year and Date: 2009-10-22
• [Presentation] III型ホスホリパーゼA_2はマスト細胞の分化成熟を制御する (2009)
  • Author(s): 武富芳隆、佐藤弘泰、田中智之、上野紀子、山本圭、原俊太郎、村上誠
  • Organizer: 第82回日本生化学会
  • Place of Presentation: 神戸
  • Year and Date: 2009-10-22
• [Presentation] 皮膚における新規脂質代謝酵素の発現誘導とその機能 (2009)
  • Author(s): 平林哲也、横山浩平、上野紀子、山本圭、村上誠
  • Organizer: 第82回日本生化学会
  • Place of Presentation: 神戸
  • Year and Date: 2009-10-22
• [Presentation] IIF型ボスホリパーゼA_2の皮膚生理機能 (2009)
  • Author(s): 山本圭, ら
  • Organizer: 第82回日本生化学会
  • Place of Presentation: 神戸
  • Year and Date: 2009-10-22
• [Presentation] 皮膚特異的分泌性ホスホリパーゼA_2の機能解析 (2009)
  • Author(s): 山本圭、武富芳隆、三木寿美、池田和貴、中西広樹、田口良、工藤一郎、村上誠
  • Organizer: 第51回日本脂質生化学会
  • Place of Presentation: 名古屋
  • Year and Date: 2009-07-31
• [Presentation] マスト細胞におけるリン脂質代謝の網羅的解析 (2009)
  • Author(s): 上野紀子、山本圭、武富芳隆、池田和貴、田口良、村上誠
  • Organizer: 第51回日本脂質生化学会
  • Place of Presentation: 名古屋
  • Year and Date: 2009-07-31
• [Presentation] III型ホスホリパーゼA_2は精子成熟を制御する (2009)
  • Author(s): 佐藤弘泰、武富芳隆、磯貝有紀、三木寿美、山本圭、石川由紀雄、石井壽晴、小林哲幸、中西広樹、池田和貴、田口良、原俊太郎、村上誠
  • Organizer: 第51回日本脂質生化学会
  • Place of Presentation: 名古屋
  • Year and Date: 2009-07-31
• [Presentation] III型ホスホリパーゼA_2はマスト細胞依存性の即時性アレルギーに関わる (2009)
  • Author(s): 武富芳隆、佐藤弘泰、田中智之、上野紀子、山本圭、田口良、工藤一郎、原俊太郎、村上誠
  • Organizer: 第51回日本脂質生化学会
  • Place of Presentation: 名古屋
  • Year and Date: 2009-07-31
• [Presentation] Group III phospholipase A_2, an endogenous bee venom phospholipase A_2 homolog, is a regulator of mast cell maturation and functions. (2009)
  • Author(s): Taketomi, Y., et. al
  • Organizer: The 9th World Congress on Inflammation
  • Place of Presentation: Tokyo
  • Year and Date: 2009-07-06
• [Presentation] Group IIF phospholipase A_2: An epidermal secreted phospholipase A_2 (2009)
  • Author(s): Yamamoto, K., et.al
  • Organizer: The 4th International Conference on phospholipase A_2 and Lipid mediators
  • Place of Presentation: Tokyo
  • Year and Date: 2009-05-26
• [Presentation] Group IID phospholipase A_2 : A dendritic cell secreted phospholipase A_2. (2009)
  • Author(s): Miki, Y., et.al
  • Organizer: The 4th International Conference on phospholipase A_2 and Lipid mediators
  • Place of Presentation: Tokyo
  • Year and Date: 2009-05-26
• [Presentation] Group III phospholipase A_2 in stromal fraction od adipose tissue controls systemic lipid homeostasis. (2009)
  • Author(s): Isogai, Y., et. al
  • Organizer: The 4th International Conference on phospholipase A_2 and Lipid mediators
  • Place of Presentation: Tokyo
  • Year and Date: 2009-05-26
• [Presentation] Impaired sperm maturation and fertility in group III phospholipase A_2-deficient mice. (2009)
  • Author(s): Sato, H., et. al
  • Organizer: The 4th International Conference on phospholipase A_2 and Lipid mediators
  • Place of Presentation: Tokyo
  • Year and Date: 2009-05-26
• [Presentation] Group III phospholipase A_2, an endogenous bee venom phospholipase A_2 homolog, is a crucial regulator of mast cell maturation and functions. (2009)
  • Author(s): Taketomi, Y., et. al
  • Organizer: The 4th International Conference on phospholipase A_2 and Lipid mediators
  • Place of Presentation: Tokyo
  • Year and Date: 2009-05-26
• [Presentation] Group III phospholipase A_2, an endogenous bee venom phospholipase A_2 homolog, is a regulator of mast cell maturation and functions. (2009)
  • Author(s): Taketomi, Y., Sato, H., Tanaka, S., Otasuka, H., Yamamoto, K., Nakamura, M., Sugimoto, Y., Kudo, I., Hara, S., Murakami, M.
  • Organizer: The 9th World Congress on Inflammation
  • Place of Presentation: Tokyo, Japan
• [Presentation] Group IIF phospholipase A_2 : An epidermal secreted phospholipase A_2. (2009)
  • Author(s): Yamamoto, K., Taketomi, Y., Miki, Y., Nahkanishi, H., Ikeda, K., Nishito, Y., Suzuki, H., Taguchi, R., Murakami, M.
  • Organizer: The 4th International Conference on phospholipase A_2 and Lipid mediators.
  • Place of Presentation: Tokyo, Japan
• [Presentation] Group IID phospholipase A_2 : A dendritic cell secreted phospholipase A_2. (2009)
  • Author(s): Miki, Y., Yamamoto, K., Taketomi, Y., Murakami, M.
  • Organizer: The 4th International Conference on phospholipase A_2 and Lipid mediators.
  • Place of Presentation: Tokyo, Japan
• [Presentation] Group III phospholipase A_2 in stromal fraction od adipose tissue controls systemic lipid homeostasis. (2009)
  • Author(s): Isogai, Y., Sato, H., Taketomi, Y., Yamamoto, K., Kobayashi, T., Murakami, M.
  • Organizer: The 4th International Conference on phospholipase A_2 and Lipid mediators.
  • Place of Presentation: Tokyo, Japan
• [Presentation] Impaired sperm maturation and fertility in group III phospholipase A_2-deficient mice. (2009)
  • Author(s): Sato, H., Taketomi, Y., Isogai, Y., Yamamoto, K., Murakami, M.
  • Organizer: The 4th International Conference on phospholipase A_2 and Lipid mediators.
  • Place of Presentation: Tokyo, Japan
• [Presentation] Group III phospholipase A_2, an endogenous bee venom phospholipase A_2 homolog, is a crucial regulator of mast cell maturation and functions. (2009)
  • Author(s): Taketomi, Y., Sato, H., Ueno, N., Yamamoto, K., Murakami, M.
  • Organizer: The 4th International Conference on phospholipase A_2 and Lipid mediators.
  • Place of Presentation: Tokyo, Japan
• [Remarks] ホームページ
  • URL: http://igakuken.or.jp/
• [Remarks] 明治薬科大学大学院講義。「分泌性ホスホリパーゼA_2の生体内機能」、2010.2.4
• [Remarks] 東京電機大学理工学部講義(一年次対象)「脂質はなぜ体に必要か?」、2010.6.21
• [Remarks] 徳島大学工学部講義(大学3年生対象)「脂質はなぜ体に必要か?」、2010.9.3
• [Remarks] 高知学芸高校の研究所訪問、「脂質はなぜ体に必要か?」、2010.10.13
• [Remarks]
  • URL: http://www.igakuken.or.jp/
• [Remarks]
  • URL: http://www.rinshoken.or.jp/P/