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The effect of atherosclerotic factors on mood disorder with treatment-resistance

Research Project

Project/Area Number 21791110
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeSingle-year Grants
Research Field Psychiatric science
Research InstitutionGunma University

Principal Investigator

NARITA Kosuke  Gunma University, 大学院・医学系研究科, 助教 (70345677)

Project Period (FY) 2009 – 2010
Project Status Completed (Fiscal Year 2010)
Budget Amount *help
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2010: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2009: ¥3,120,000 (Direct Cost: ¥2,400,000、Indirect Cost: ¥720,000)
Keywords双極性障害 / 治療抵抗性 / Voxel-Based Morphometry(VBM) / 動脈硬化 / インスリン抵抗性 / Voxel-Based Morphometry (VBM) / 治療抵抗性気分障害 / 頭部MRI
Research Abstract

In this preliminary study with a cross-sectional design, we examined the regional gray matter (GM) volume in 14 bipolar II patients with RC, 17 patients without RC and 84 healthy controls by insulin-resistance index, calculated from blood glucose and insulin concentrations, and whole-brain and region-of-interest (ROI) analysis methods, using magnetic resonance imaging with voxel-based morphometry. Whole-brain analysis in this study revealed that the bipolar II patients with RC showed GM volume reductions in the bilateral hemispheres of the medial orbital prefrontal cortex, ventromedial prefrontal cortex, anterior cingulate, insula and parahippocampus, in the left hemisphere of the inferior temporal cortex and cerebellum, and in the brainstem, compared with the healthy controls. Moreover, ROI analysis focusing on the ventral prefrontal cortex, i.e., Brodmann areas 10, 11 and 47, revealed that the bipolar II patients with RC showed GM volume reduction in the ventromedial prefrontal cortex, compared with the patients without RC. The findings of our pilot study suggest that the ventromedial prefrontal cortex is associated with the generation of RC in bipolar II disorder. There were no significant results regarding insulin-resistance index.

Report

(3 results)
  • 2010 Annual Research Report   Final Research Report ( PDF )
  • 2009 Annual Research Report
  • Research Products

    (11 results)

All 2011 2010 2009 Other

All Journal Article (10 results) (of which Peer Reviewed: 10 results) Presentation (1 results)

  • [Journal Article] Volume reduction of ventromedial prefrontal cortex in bipolar II patients with rapid cycling : A voxel-based morphometric study.2011

    • Author(s)
      Narita K, Suda M, Takei Y, Aoyama Y, Majima T, Kameyama M, Kosaka H, Amanuma M, Fukuda M, Mikuni M
    • Journal Title

      Prog Neuropsychopharmacol Biol Psychiatry. 35

      Pages: 439-445

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Volume reduction of ventromedial prefrontal cortex in bipolar II patients with rapid cycling : A voxel-based morphometric study.2011

    • Author(s)
      Narita K, Suda M, Takei Y, Aoyama Y, Majima T, Kameyama M, Kosaka H, Amanuma M, Fukuda M, Mikuni M
    • Journal Title

      Prog Neuropsychopharmacol Biol Psychiatry

      Volume: 35 Pages: 439-45

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Relationship of parental bonding styles with gray matter volume of dorsolateral prefrontal cortex in young adults.2010

    • Author(s)
      Narita K, Takei Y, Suda M, Aoyama Y, Uehara T, Kosaka H, Amanuma M, Fukuda M, Mikuni M
    • Journal Title

      Prog Neuropsychopharmacol Biol Psychiatry. 34:

      Pages: 624-631

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Total and regional brain volume reductions due to the Syndrome of Irreversible Lithium-Effectuated Neurotoxicity (SILENT) : a voxel-based morphometric study.2010

    • Author(s)
      Ikeda Y, Kameyama M, Narita K, Takei Y, Suda M, Aoyama Y, Yuuki N, Sakurai N, Fukuda M, Mikuni M, Amanuma M
    • Journal Title

      Prog Neuropsychopharmacol Biol Psychiatry. 34

      Pages: 244-246

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Relationship of parental bonding styles with gray matter volume of dorsolateral prefrontal cortex in young adults.2010

    • Author(s)
      Narita K, Takei Y, Suda M, Aoyama Y, Uehara T, Kosaka H, Amanuma M, Fukuda M, Mikuni M
    • Journal Title

      Prog Neuropsychopharmacol Biol Psychiatry

      Volume: 34 Pages: 624-31

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Total and regional brain volume reductions due to the Syndrome of Irreversible Lithium-Effectuated Neurotoxicity (SILENT) : a voxel-based morphometric study.2010

    • Author(s)
      Ikeda Y, Kameyama M, Narita K, Takei Y, Suda M, Aoyama Y, Yuuki N, Sakurai N, Fukuda M, Mikuni M, Amanuma M
    • Journal Title

      Prog Neuropsychopharmacol Biol Psychiatry

      Volume: 34 Pages: 244-6

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Total and regional brain volume reductions due to the Syndrome of Irreversible Lithium-Effectuated Neurotoxicity(SILENT) : a voxel-based morphometric study2010

    • Author(s)
      Ikeda Y, Kameyama M, Narita K, et al.
    • Journal Title

      Prog Neuropsychopharmacol Biol Psychiatry 34

      Pages: 244-246

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Relationship between plasma leptin level and brain structure in elderly : a voxel-based morphometric study.2009

    • Author(s)
      Narita K, Kosaka H, Okazawa H, Murata T, Wada Y
    • Journal Title

      Biol Psychiatry. 65

      Pages: 992-994

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Relationship between plasma leptin level and brain structure in elderly : a voxel-based morphometric study2009

    • Author(s)
      K Narita, et al.
    • Journal Title

      Biological Psychiatry 65

      Pages: 992-994

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Relationship of parental bonding styles with gray matter volume of dorsolateral prefrontal cortex in young adults

    • Author(s)
      K Narita, et al.
    • Journal Title

      Prog Neuropsychopharmacol Biol Psychiatry (In press)

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Presentation] DEX試験に対して過剰抑制を示す気分障害群の臨床的特徴および画像所見に関する検討2009

    • Author(s)
      成田耕介
    • Organizer
      精神神経系薬物治療研究報告会
    • Place of Presentation
      千里ライフサイエンスセンター
    • Year and Date
      2009-12-04
    • Related Report
      2009 Annual Research Report

URL: 

Published: 2009-04-01   Modified: 2016-04-21  

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