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Comprehensive genetic analysis of CABIN1 in schizophrenia

Research Project

Project/Area Number 21791114
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeSingle-year Grants
Research Field Psychiatric science
Research InstitutionNiigata University

Principal Investigator

WATANABE Yuichiro  Niigata University, 保健管理センター, 講師 (90401744)

Project Period (FY) 2009 – 2010
Project Status Completed (Fiscal Year 2010)
Budget Amount *help
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2010: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2009: ¥2,600,000 (Direct Cost: ¥2,000,000、Indirect Cost: ¥600,000)
Keywords統合失調症 / 関連解析 / コピー数多様性
Research Abstract

The gene encoding calcineurin binding protein 1 (CABIN1) is a promising candidate gene for schizophrenia. To assess whether CABIN1 is implicated in vulnerability to schizophrenia, we conducted a case-control association study between CABIN1 and schizophrenia. The results revealed no evidence of an association between CABIN1 and schizophrenia using 11 tagging single nucleotide polymorphisms and a copy number variation. Our results suggest that CABIN1 may not confer increased susceptibility for schizophrenia.

Report

(3 results)
  • 2010 Annual Research Report   Final Research Report ( PDF )
  • 2009 Annual Research Report
  • Research Products

    (57 results)

All 2011 2010 2009 Other

All Journal Article (30 results) (of which Peer Reviewed: 16 results) Presentation (24 results) Book (3 results)

  • [Journal Article] Functional polymorphism in the GPR55 gene is associated with anorexia nervosa2011

    • Author(s)
      Ishiguro H, et al.
    • Journal Title

      Synapse

      Volume: 65 Pages: 103-108

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] A case-control association analysis of CABIN1 with schizophrenia in a Japanese population.2010

    • Author(s)
      Watanabe, Y., Nunokawa, A., Kaneko, N., Someya, T.
    • Journal Title

      Journal of Human Genetics 55

      Pages: 179-181

    • NAID

      10030734099

    • Related Report
      2010 Final Research Report
  • [Journal Article] Cytokine hypothesis of schizophrenia pathogenesis : evidence from human studies and animal models.2010

    • Author(s)
      Watanabe, Y., Someya, T., Nawa, H.
    • Journal Title

      Psychiatry and Clinical Neurosciences 64

      Pages: 217-230

    • Related Report
      2010 Final Research Report
  • [Journal Article] A case-control study and meta-analysis of association between a common copy number variation of the glutathione S-transferase mu 1 (GSTM1) gene and schizophrenia.2010

    • Author(s)
      Watanabe, Y., Nunokawa, A., Kaneko, N., Someya, T.
    • Journal Title

      Schizophrenia Research 124

      Pages: 236-237

    • Related Report
      2010 Final Research Report
  • [Journal Article] Failure to find an association between myosin heavy chain 9, non-muscle (MYH9) and schizophrenia : a three-stage case-control association study.2010

    • Author(s)
      Amagane, H., Watanabe, Y., Kaneko, N., Nunokawa, A., Muratake, T., Ishiguro, H., Arinami, T., Ujike, H., Inada, T., Iwata, N., Kunugi, H., Sasaki, T., Hashimoto, R., Itokawa, M., Ozaki, N., Someya, T.
    • Journal Title

      Schizophrenia Research 118

      Pages: 106-112

    • Related Report
      2010 Final Research Report
  • [Journal Article] The dopamine D3 receptor (DRD3) gene and risk of schizophrenia : case-control studies and an updated meta-analysis.2010

    • Author(s)
      Nunokawa, A., Watanabe, Y., Kaneko, N., Sugai, T., Yazaki, S., Arinami, T., Ujike, H., Inada, T., Iwata, N., Kunugi, H., Sasaki, T., Itokawa, M., Ozaki, N., Hashimoto, R., Someya, T.
    • Journal Title

      Schizophrenia Research 116

      Pages: 61-67

    • Related Report
      2010 Final Research Report
  • [Journal Article] 精神疾患2010

    • Author(s)
      渡部雄一郎, 染矢俊幸
    • Journal Title

      日本臨床 68(増8)

      Pages: 402-405

    • Related Report
      2010 Final Research Report
  • [Journal Article] Failure to find an association between myosin heavy chain 9, non muscle (MYH9) and schizophrenia : a three-stage case-control association study2010

    • Author(s)
      Amagane H, et al.
    • Journal Title

      Schizophrenia Research

      Volume: 118 Pages: 106-112

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Brain cannabinoid CB2 receptor in schizophrenia2010

    • Author(s)
      Ishiguro H, et al.
    • Journal Title

      Biological Psychiatry

      Volume: 67 Pages: 974-982

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Diagnostic classification of schizophrenia by neural network analysis of blood-based gene expression signatures2010

    • Author(s)
      Takahashi M, et al.
    • Journal Title

      Schizophrenia Research

      Volume: 119 Pages: 210-218

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Replication study of association between ADCYAP1 gene polymorphisms and schizophrenia2010

    • Author(s)
      Koga M, et al.
    • Journal Title

      Psychiatric Genetics

      Volume: 20 Pages: 123-125

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Supportive evidence for reduced expression of GNB1L in schizophrenia2010

    • Author(s)
      Ishiguro H, et al.
    • Journal Title

      Schizophrenia Bulletin

      Volume: 36 Pages: 756-65

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Measurement and comparison of serum neuregulin 1 immunoreactivity in control subjects and patients with schizophrenia : an influence of its genetic polymorphism2010

    • Author(s)
      Shibuya M, et al.
    • Journal Title

      Journal of Neural Transmission

      Volume: 117 Pages: 887-895

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] An association study between the dymeclin gene and schizophrenia in the Japanese population2010

    • Author(s)
      Yazaki S, et al.
    • Journal Title

      Journal of Human Genetics

      Volume: 55 Pages: 631-634

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] A case-control study and meta-analysis of association between a common copy number variation of the glutathione S-transferase mu 1 (GSTM1) gene and schizophrenia2010

    • Author(s)
      Watanabe Y, et al.
    • Journal Title

      Schizophrenia Research

      Volume: 124 Pages: 236-237

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Cytokine hypothesis of schizophrenia pathogenesis : evidence from human studies and animal models2010

    • Author(s)
      Watanabe Y, et al.
    • Journal Title

      Psychiatry and Clinical Neurosciences

      Volume: 64 Pages: 217-230

    • Related Report
      2010 Annual Research Report
  • [Journal Article] 精神疾患2010

    • Author(s)
      渡部雄一郎, ほか
    • Journal Title

      日本臨床

      Volume: 68 Pages: 402-405

    • Related Report
      2010 Annual Research Report
  • [Journal Article] The dopamine D3 receptor (DRD3) gene and risk of schizophrenia : case-control studies and an updated meta-analysis2010

    • Author(s)
      Nunokawa A, et al.
    • Journal Title

      Schizophrenia Research 116

      Pages: 61-67

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] A case-control association study of CABIN1 with schizophrenia in a Japanese population2010

    • Author(s)
      Watanabe Y, et al.
    • Journal Title

      Journal of Human Genetics 55

      Pages: 179-181

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Donepezil服用後にパーキンソニズムが悪化したレビー小体型認知症の1例2010

    • Author(s)
      常山暢人, ほか
    • Journal Title

      臨床精神薬理 13

      Pages: 397-402

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] A two-stage case-control association study of PADI2 with schizophrenia.2009

    • Author(s)
      Watanabe, Y., Nunokawa, A., Kaneko, K., Arinami, T., Ujike, H., Inada, T., Iwata, N., Kunugi, H., Itokawa, M., Otowa, T., Ozaki, N., Someya, T.
    • Journal Title

      Journal of Human Genetics 54

      Pages: 430-432

    • NAID

      10030731190

    • Related Report
      2010 Final Research Report
  • [Journal Article] モデル動物を用いた統合失調症病態解析2009

    • Author(s)
      渡部雄一郎, 那波宏之, 染矢俊幸
    • Journal Title

      脳と精神の医学 20

      Pages: 213-220

    • NAID

      10028262363

    • Related Report
      2010 Final Research Report
  • [Journal Article] 統合失調症とゲノミックス2009

    • Author(s)
      渡部雄一郎, 布川綾子, 金子尚史, 那波宏之, 染矢俊幸
    • Journal Title

      臨床精神医学 38

      Pages: 1031-1037

    • Related Report
      2010 Final Research Report
  • [Journal Article] Involvement of SMARCA2/BRM in the SWI/SNF chromatin-remodeling complex in schizophrenia2009

    • Author(s)
      Koga M, et al.
    • Journal Title

      Human Molecular Genetics 18

      Pages: 2483-2494

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Preliminary genome-wide association study of bipolar disorder in the Japanese population2009

    • Author(s)
      Hattori E., et al.
    • Journal Title

      American Journal of Medical Genetics Part B 150B

      Pages: 1110-1117

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] A two-stage case-control association study of PADI2 with schizophrenia2009

    • Author(s)
      Watanabe Y, et al.
    • Journal Title

      Journal of Human Genetics 54

      Pages: 430-432

    • NAID

      10030731190

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 統合失調症とゲノミックス2009

    • Author(s)
      渡部雄一郎, ほか
    • Journal Title

      臨床精神医学 38

      Pages: 1031-1037

    • Related Report
      2009 Annual Research Report
  • [Journal Article] モデル動物を用いた統合失調症病態解析2009

    • Author(s)
      渡部雄一郎, ほか
    • Journal Title

      脳と精神の医学 20

      Pages: 213-220

    • NAID

      10028262363

    • Related Report
      2009 Annual Research Report
  • [Journal Article] ミオシン重鎖9遺伝子と統合失調症の関連:大規模確認解析2009

    • Author(s)
      渡部雄一郎, ほか
    • Journal Title

      新潟県医師会報 715

      Pages: 8-9

    • Related Report
      2009 Annual Research Report
  • [Journal Article] Reduced thalamus volume in non-right-handed male patients with autism spectrum disorders

    • Author(s)
      Egawa J, et al.
    • Journal Title

      Psychiatry and Clinical Neuroscience

      Volume: (In press)

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Presentation] 抗精神病薬治療下主観的ウェルビーイング評価尺度短縮版日本語版の心理測定学的特性に関する予備的研究2010

    • Author(s)
      布川綾子, ほか
    • Organizer
      第30回日本精神科診断学会
    • Place of Presentation
      九州大学医学部百年講堂(福岡市)
    • Year and Date
      2010-11-12
    • Related Report
      2010 Annual Research Report
  • [Presentation] 学生健診における健診自動化システム導入の成果と課題2010

    • Author(s)
      神主京子, ほか
    • Organizer
      第48回全国大学保健管理研究集会
    • Place of Presentation
      幕張メッセ(千葉市)
    • Year and Date
      2010-10-21
    • Related Report
      2010 Annual Research Report
  • [Presentation] 大学生における統合失調症発症危険状態スクリーニングに関する予備的研究2010

    • Author(s)
      渡部雄一郎, ほか
    • Organizer
      第48回全国大学保健管理研究集会
    • Place of Presentation
      幕張メッセ(千葉市)
    • Year and Date
      2010-10-21
    • Related Report
      2010 Annual Research Report
  • [Presentation] 平成21年度に新潟大学で発生したインフルエンザの特徴2010

    • Author(s)
      真島一郎, ほか
    • Organizer
      第48回全国大学保健管理研究集会
    • Place of Presentation
      幕張メッセ(千葉市)
    • Year and Date
      2010-10-21
    • Related Report
      2010 Annual Research Report
  • [Presentation] ミオシン重鎖9遺伝子は統合失調症と関連しない2010

    • Author(s)
      渡部雄一郎, 天金秀樹, 金子尚史, 布川綾子, 村竹辰之, 石黒浩毅, 有波忠雄, 氏家寛, 稲田俊也, 岩田仲生, 功刀浩, 佐々木司, 橋本亮太, 糸川昌成, 尾崎紀夫, 染矢俊幸
    • Organizer
      第32回日本生物学的精神医学会
    • Place of Presentation
      リーガロイヤルホテル小倉(北九州市)
    • Year and Date
      2010-10-09
    • Related Report
      2010 Annual Research Report 2010 Final Research Report
  • [Presentation] ドパミンD3受容体遺伝子と統合失調症のリスク2010

    • Author(s)
      布川綾子, 渡部雄一郎, 金子尚史, 須貝拓朗, 矢崎沙織, 有波忠雄, 氏家寛, 稲田俊也, 岩田仲生, 功刀浩, 佐々木司, 糸川昌成, 尾崎紀夫, 橋本亮太, 染矢俊幸
    • Organizer
      第32回日本生物学的精神医学会
    • Place of Presentation
      リーガロイヤルホテル小倉(北九州市)
    • Year and Date
      2010-10-09
    • Related Report
      2010 Annual Research Report 2010 Final Research Report
  • [Presentation] 統合失調症多発罹患家系における全ゲノムコピー数多型検索2010

    • Author(s)
      金子尚史, 渡部雄一郎, 村竹辰之, 布川綾子, 染矢俊幸
    • Organizer
      第32回日本生物学的精神医学会
    • Place of Presentation
      リーガロイヤルホテル小倉(北九州市)
    • Year and Date
      2010-10-09
    • Related Report
      2010 Annual Research Report 2010 Final Research Report
  • [Presentation] トリプトファン水酸化酵素2(TPH2)遺伝子と広汎性発達障害との関連解析2010

    • Author(s)
      江川純, ほか
    • Organizer
      第32回日本生物学的精神医学会
    • Place of Presentation
      リーガロイヤルホテル小倉(北九州市)
    • Year and Date
      2010-10-09
    • Related Report
      2010 Annual Research Report
  • [Presentation] MTHFR遺伝子多型と統合失調症との関連2010

    • Author(s)
      有波忠雄, ほか
    • Organizer
      第5回日本統合失調症学会
    • Place of Presentation
      九州大学医学部百年講堂(福岡)
    • Year and Date
      2010-03-27
    • Related Report
      2009 Annual Research Report
  • [Presentation] ドネペジルによりパーキンソニズムが悪化したレバー小体型認知症の1例2009

    • Author(s)
      渡部雄一郎, ほか
    • Organizer
      第19回日本臨床精神神経薬理学会
    • Place of Presentation
      国立京都国際会館(京都)
    • Year and Date
      2009-11-14
    • Related Report
      2009 Annual Research Report
  • [Presentation] GPR55 and anorexia nervosa2009

    • Author(s)
      Ishiguro H, et al.
    • Organizer
      Society for Neuroscience 39th Annual Meeting
    • Place of Presentation
      McCormick Place convention center (Chicago)
    • Year and Date
      2009-10-21
    • Related Report
      2009 Annual Research Report
  • [Presentation] 二酸化炭素吸入試験により誘発されるパニック症状に影響を及ぼす要因の探索:健常者における検討2009

    • Author(s)
      阿部亮, ほか
    • Organizer
      第29回日本精神科診断学会
    • Place of Presentation
      ハイアットリージェンシー東京(東京)
    • Year and Date
      2009-10-17
    • Related Report
      2009 Annual Research Report
  • [Presentation] Dymeclin遺伝子と統合失調症との関連解析2009

    • Author(s)
      矢崎沙織, ほか
    • Organizer
      人類遺伝学会第54回大会
    • Place of Presentation
      グランドプリンスホテル高輪(東京)
    • Year and Date
      2009-09-26
    • Related Report
      2009 Annual Research Report
  • [Presentation] 大学における職場復帰支援の現状と問題点2009

    • Author(s)
      村山賢一, ほか
    • Organizer
      第47回全国大学保健管理研究集会
    • Place of Presentation
      札幌コンベンションセンター(札幌)
    • Year and Date
      2009-09-17
    • Related Report
      2009 Annual Research Report
  • [Presentation] 新潟大学における学校伝染病への対策について2009

    • Author(s)
      野口愛子, ほか
    • Organizer
      第47回全国大学保健管理研究集会
    • Place of Presentation
      札幌コンベンションセンター(札幌)
    • Year and Date
      2009-09-17
    • Related Report
      2009 Annual Research Report
  • [Presentation] 新入生の麻しんの実態について2009

    • Author(s)
      真島一郎, ほか
    • Organizer
      第47回全国大学保健管理研究集会
    • Place of Presentation
      札幌コンベンションセンター(札幌)
    • Year and Date
      2009-09-17
    • Related Report
      2009 Annual Research Report
  • [Presentation] ドパミンD3受容体遺伝子と統合失調症および前頭葉機能との関連2009

    • Author(s)
      布川綾子, 渡部雄一郎, 金子尚史, 須貝拓朗, 染矢俊幸
    • Organizer
      第31回日本生物学的精神医学会
    • Place of Presentation
      国立京都国際会館(京都市)
    • Year and Date
      2009-04-25
    • Related Report
      2010 Final Research Report
  • [Presentation] 二段階サンプルによる関節リウマチ感受性遺伝子と統合失調症との関連研究2009

    • Author(s)
      金子尚史, 渡部雄一郎, 布川綾子, 村竹辰之, 有波忠雄, 氏家寛, 稲田俊也, 岩田仲生, 功刀浩, 糸川昌成, 音羽健司, 尾崎紀夫, 染矢俊幸
    • Organizer
      第31回日本生物学的精神医学会.
    • Place of Presentation
      国立京都国際会館(京都市)
    • Year and Date
      2009-04-25
    • Related Report
      2010 Final Research Report
  • [Presentation] ペプチジルアルギニンデイミナーゼ2(PADI2)遺伝子と統合失調症との関連2009

    • Author(s)
      渡部雄一郎, 布川綾子, 金子尚史, 染矢俊幸
    • Organizer
      第31回日本生物学的精神医学会
    • Place of Presentation
      国立京都国際会館(京都市)
    • Year and Date
      2009-04-25
    • Related Report
      2010 Final Research Report
  • [Presentation] ペプチジルアルギニンデイミナーゼ2(PADI2)遺伝子と統合失調症との関連2009

    • Author(s)
      渡部雄一郎, ほか
    • Organizer
      第31回日本生物学的精神医学会
    • Place of Presentation
      国立京都国際会館(京都)
    • Year and Date
      2009-04-25
    • Related Report
      2009 Annual Research Report
  • [Presentation] 二段階サンプルによる関節リウマチ感受性遺伝子と統合失調症との関連研究2009

    • Author(s)
      金子尚史, ほか
    • Organizer
      第31回日本生物学的精神医学会
    • Place of Presentation
      国立京都国際会館(京都)
    • Year and Date
      2009-04-25
    • Related Report
      2009 Annual Research Report
  • [Presentation] ドパミンD3受容体遺伝子と統合失調症および前頭葉機能との関連2009

    • Author(s)
      布川綾子, ほか
    • Organizer
      第31回日本生物学的精神医学会
    • Place of Presentation
      国立京都国際会館(京都)
    • Year and Date
      2009-04-25
    • Related Report
      2009 Annual Research Report
  • [Presentation] MYH9遺伝子と統合失調症との関連解析2009

    • Author(s)
      渡部雄一郎, 布川綾子, 金子尚史, 染矢俊幸
    • Organizer
      第52回日本神経化学会大会
    • Place of Presentation
      ホテル天坊(渋川市)
    • Related Report
      2010 Final Research Report
  • [Presentation] MYH9遺伝子と統合失調症との関連解析2009

    • Author(s)
      渡部雄一郎, ほか
    • Organizer
      第52回日本神経化学会大会
    • Place of Presentation
      ホテル天坊(渋川)
    • Related Report
      2009 Annual Research Report
  • [Book] 統合失調症の薬物療法.臨床精神薬理ハンドブック第2版2009

    • Author(s)
      渡部雄一郎, ほか
    • Publisher
      医学書院
    • Related Report
      2009 Annual Research Report
  • [Book] 統合失調症の薬物療法 臨床精神薬理ハンドブック第2版

    • Author(s)
      渡部雄一郎, 染矢俊幸
    • Publisher
      医学書院
    • Related Report
      2010 Final Research Report
  • [Book] 統合失調症の新たなストラテジー-非定型抗精神病薬によるアプローチ-

    • Author(s)
      北村秀明, ほか
    • Publisher
      先端医学社(印刷中)
    • Related Report
      2010 Annual Research Report

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Published: 2009-04-01   Modified: 2016-04-21  

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